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Article: An evaluation of the PyloriTek test for the diagnosis of Helicobacter pylori infection in Chinese patients before and after eradication therapy

TitleAn evaluation of the PyloriTek test for the diagnosis of Helicobacter pylori infection in Chinese patients before and after eradication therapy
Authors
KeywordsDiagnosis
Helicobacter pylori
Rapid urease test
Urease reagent strip
Issue Date2001
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGH
Citation
Journal Of Gastroenterology And Hepatology, 2001, v. 16 n. 9, p. 976-980 How to Cite?
AbstractBackground and Aim: The PyloriTek Test Kit (a 1-h rapid urease test) was developed for the rapid diagnosis of Helicobacter pylori (H. pylori) during endoscopy. Most studies were performed in Western populations. The aim of this study was to evaluate the PyloriTek test for the diagnosis of H. pylori infection in Chinese population. Methods: Eligible patients without prior treatment or who had had recent eradication of H. pylori were recruited. During endoscopy, biopsies were taken from the antrum and corpus for an in-house rapid urease test (RUT), histology and for the PyloriTek test (one antral and one corpus biopsy). Results of the PyloriTek test were compared with the gold standard (RUT and histology). Results: Analysis of PyloriTek test results from the antrum alone (101 patients before eradication and 52 patients after eradication) showed a sensitivity, specificity, and accuracy of 96.3, 97.9, and 97.0%, respectively, for cases before eradication, and an accuracy of 100% for cases after eradication. The benefit of an additional body biopsy was marginal and only occurred in the pre-eradication group. Conclusion: The PyloriTek test was highly accurate for the diagnosis of H. pylori infection before and after eradication therapy, with a final result available at 1 h, which is unmatched by any invasive test so far. It enhances clinical decision-making by allowing the clinicians or endoscopists to start therapy on the same day of an endoscopy visit. One biopsy from the antrum is highly reliable for this purpose. © 2001 Blackwell Science Asia Pty Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/77777
ISSN
2015 Impact Factor: 3.322
2015 SCImago Journal Rankings: 1.190
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, WMen_HK
dc.contributor.authorWong, BCYen_HK
dc.contributor.authorTang, VSYen_HK
dc.contributor.authorLai, KCen_HK
dc.contributor.authorYuen, STen_HK
dc.contributor.authorLeung, SYen_HK
dc.contributor.authorHu, WHen_HK
dc.contributor.authorLam, SKen_HK
dc.date.accessioned2010-09-06T07:35:36Z-
dc.date.available2010-09-06T07:35:36Z-
dc.date.issued2001en_HK
dc.identifier.citationJournal Of Gastroenterology And Hepatology, 2001, v. 16 n. 9, p. 976-980en_HK
dc.identifier.issn0815-9319en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77777-
dc.description.abstractBackground and Aim: The PyloriTek Test Kit (a 1-h rapid urease test) was developed for the rapid diagnosis of Helicobacter pylori (H. pylori) during endoscopy. Most studies were performed in Western populations. The aim of this study was to evaluate the PyloriTek test for the diagnosis of H. pylori infection in Chinese population. Methods: Eligible patients without prior treatment or who had had recent eradication of H. pylori were recruited. During endoscopy, biopsies were taken from the antrum and corpus for an in-house rapid urease test (RUT), histology and for the PyloriTek test (one antral and one corpus biopsy). Results of the PyloriTek test were compared with the gold standard (RUT and histology). Results: Analysis of PyloriTek test results from the antrum alone (101 patients before eradication and 52 patients after eradication) showed a sensitivity, specificity, and accuracy of 96.3, 97.9, and 97.0%, respectively, for cases before eradication, and an accuracy of 100% for cases after eradication. The benefit of an additional body biopsy was marginal and only occurred in the pre-eradication group. Conclusion: The PyloriTek test was highly accurate for the diagnosis of H. pylori infection before and after eradication therapy, with a final result available at 1 h, which is unmatched by any invasive test so far. It enhances clinical decision-making by allowing the clinicians or endoscopists to start therapy on the same day of an endoscopy visit. One biopsy from the antrum is highly reliable for this purpose. © 2001 Blackwell Science Asia Pty Ltd.en_HK
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGHen_HK
dc.relation.ispartofJournal of Gastroenterology and Hepatologyen_HK
dc.subjectDiagnosisen_HK
dc.subjectHelicobacter pylorien_HK
dc.subjectRapid urease testen_HK
dc.subjectUrease reagent stripen_HK
dc.subject.meshAnti-Bacterial Agents - therapeutic useen_HK
dc.subject.meshAnti-Ulcer Agents - therapeutic useen_HK
dc.subject.meshBiopsyen_HK
dc.subject.meshChinaen_HK
dc.subject.meshEndoscopy, Digestive Systemen_HK
dc.subject.meshGastric Mucosa - pathologyen_HK
dc.subject.meshGastritis - diagnosis - drug therapy - pathologyen_HK
dc.subject.meshHelicobacter Infections - diagnosis - drug therapy - pathologyen_HK
dc.subject.meshHelicobacter pylorien_HK
dc.subject.meshHumansen_HK
dc.subject.meshPeptic Ulcer - diagnosis - drug therapy - pathologyen_HK
dc.subject.meshPredictive Value of Testsen_HK
dc.subject.meshProspective Studiesen_HK
dc.subject.meshReagent Stripsen_HK
dc.subject.meshUrease - analysisen_HK
dc.titleAn evaluation of the PyloriTek test for the diagnosis of Helicobacter pylori infection in Chinese patients before and after eradication therapyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0815-9319&volume=16&issue=9&spage=976&epage=980&date=2001&atitle=An+evaluation+of+the+PyloriTek+test+for+the+diagnosis+of+Helicobacter+pylori+infection+in+Chinese+patients+before+and+after+eradication+therapyen_HK
dc.identifier.emailWong, BCY:bcywong@hku.hken_HK
dc.identifier.emailLeung, SY:suetyi@hkucc.hku.hken_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.identifier.authorityLeung, SY=rp00359en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1046/j.1440-1746.2001.02565.xen_HK
dc.identifier.pmid11595060-
dc.identifier.scopuseid_2-s2.0-0034795585en_HK
dc.identifier.hkuros72114en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034795585&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume16en_HK
dc.identifier.issue9en_HK
dc.identifier.spage976en_HK
dc.identifier.epage980en_HK
dc.identifier.isiWOS:000177633500005-
dc.publisher.placeAustraliaen_HK
dc.identifier.scopusauthoridWong, WM=7403972413en_HK
dc.identifier.scopusauthoridWong, BCY=7402023340en_HK
dc.identifier.scopusauthoridTang, VSY=6701711948en_HK
dc.identifier.scopusauthoridLai, KC=7402135595en_HK
dc.identifier.scopusauthoridYuen, ST=7103160927en_HK
dc.identifier.scopusauthoridLeung, SY=7202044886en_HK
dc.identifier.scopusauthoridHu, WH=25932937100en_HK
dc.identifier.scopusauthoridLam, SK=7402279473en_HK

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