File Download
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1111/j.1365-2036.2006.03029.x
- Scopus: eid_2-s2.0-33746424431
- PMID: 16907890
- WOS: WOS:000239306800002
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Clinical features, biochemical parameters, and virological profiles of patients with hepatocellular carcinoma in Hong Kong
Title | Clinical features, biochemical parameters, and virological profiles of patients with hepatocellular carcinoma in Hong Kong |
---|---|
Authors | |
Issue Date | 2006 |
Publisher | Blackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APT |
Citation | Alimentary Pharmacology And Therapeutics, 2006, v. 24 n. 4, p. 573-583 How to Cite? |
Abstract | Background: Clinical features of hepatocellular carcinoma patients are changing because of screening. Aim: To examine the clinical features of hepatocellular carcinoma patients in Hong Kong and validity of different staging systems. Methods: A total of 223 Chinese patients with hepatocellular carcinoma were studied. Results: Seventy-eight percent of hepatocellular carcinoma patients had chronic hepatitis B (43% diagnosed by screening). Hepatitis B positivity, weight loss, jaundice, encephalopathy, alpha-fetoprotein level, portal vein thrombosis, extrahepatic metastasis, and treatment were shown to be independent factors affecting survival. Of chronic hepatitis B patients, hepatitis B virus DNA levels (P = 0.001) and portal vein thrombosis (P = 0.008) were independent factors affecting survival. Seventy-six percent of chronic hepatitis B patients with hepatocellular carcinoma were hepatitis B e antigen negative. Screening patients had hepatocellular carcinoma detected at an earlier stage and better survival (median survival: 21 vs. 4 months, P < 0.0001). All staging systems had good stratification of survival. Prognosis and median survival generated were different when compared with the US data. Conclusions: Chronic hepatitis B was the most common cause of hepatocellular carcinoma in Hong Kong. High-risk chronic hepatitis B patients should be followed irrespective of the hepatitis B e antigen status. Hepatitis B virus DNA levels at the time of diagnosis are an important survival predictor. Screening detected hepatocellular carcinoma at an earlier stage and prolonged survival. Staging systems should be validated in different populations. © 2006 The Authors. |
Persistent Identifier | http://hdl.handle.net/10722/77715 |
ISSN | 2023 Impact Factor: 6.6 2023 SCImago Journal Rankings: 2.794 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cheung, TK | en_HK |
dc.contributor.author | Lai, CL | en_HK |
dc.contributor.author | Wong, BCY | en_HK |
dc.contributor.author | Fung, J | en_HK |
dc.contributor.author | Yuen, MF | en_HK |
dc.date.accessioned | 2010-09-06T07:34:56Z | - |
dc.date.available | 2010-09-06T07:34:56Z | - |
dc.date.issued | 2006 | en_HK |
dc.identifier.citation | Alimentary Pharmacology And Therapeutics, 2006, v. 24 n. 4, p. 573-583 | en_HK |
dc.identifier.issn | 0269-2813 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/77715 | - |
dc.description.abstract | Background: Clinical features of hepatocellular carcinoma patients are changing because of screening. Aim: To examine the clinical features of hepatocellular carcinoma patients in Hong Kong and validity of different staging systems. Methods: A total of 223 Chinese patients with hepatocellular carcinoma were studied. Results: Seventy-eight percent of hepatocellular carcinoma patients had chronic hepatitis B (43% diagnosed by screening). Hepatitis B positivity, weight loss, jaundice, encephalopathy, alpha-fetoprotein level, portal vein thrombosis, extrahepatic metastasis, and treatment were shown to be independent factors affecting survival. Of chronic hepatitis B patients, hepatitis B virus DNA levels (P = 0.001) and portal vein thrombosis (P = 0.008) were independent factors affecting survival. Seventy-six percent of chronic hepatitis B patients with hepatocellular carcinoma were hepatitis B e antigen negative. Screening patients had hepatocellular carcinoma detected at an earlier stage and better survival (median survival: 21 vs. 4 months, P < 0.0001). All staging systems had good stratification of survival. Prognosis and median survival generated were different when compared with the US data. Conclusions: Chronic hepatitis B was the most common cause of hepatocellular carcinoma in Hong Kong. High-risk chronic hepatitis B patients should be followed irrespective of the hepatitis B e antigen status. Hepatitis B virus DNA levels at the time of diagnosis are an important survival predictor. Screening detected hepatocellular carcinoma at an earlier stage and prolonged survival. Staging systems should be validated in different populations. © 2006 The Authors. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Blackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APT | en_HK |
dc.relation.ispartof | Alimentary Pharmacology and Therapeutics | en_HK |
dc.rights | Alimentary Pharmacology and Therapeutics. Copyright © Blackwell Publishing Ltd. | en_HK |
dc.subject.mesh | Adult | en_HK |
dc.subject.mesh | Aged | en_HK |
dc.subject.mesh | Aged, 80 and over | en_HK |
dc.subject.mesh | Carcinoma, Hepatocellular - ethnology - pathology - virology | en_HK |
dc.subject.mesh | China - ethnology | en_HK |
dc.subject.mesh | Female | en_HK |
dc.subject.mesh | Hepatitis B, Chronic - etiology | en_HK |
dc.subject.mesh | Hong Kong - epidemiology | en_HK |
dc.subject.mesh | Humans | en_HK |
dc.subject.mesh | Male | en_HK |
dc.subject.mesh | Middle Aged | en_HK |
dc.subject.mesh | Survival Analysis | en_HK |
dc.title | Clinical features, biochemical parameters, and virological profiles of patients with hepatocellular carcinoma in Hong Kong | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0269-2813&volume=24&issue=4&spage=573&epage=583&date=2006&atitle=Clinical+Features,+Biochemical+Parameters,+and+Virological+Profiles+of+Patients+with+Hepatocellular+Carcinoma+in+Hong+Kong | en_HK |
dc.identifier.email | Lai, CL:hrmelcl@hku.hk | en_HK |
dc.identifier.email | Wong, BCY:bcywong@hku.hk | en_HK |
dc.identifier.email | Fung, J:jfung@sicklehut.com | en_HK |
dc.identifier.email | Yuen, MF:mfyuen@hkucc.hku.hk | en_HK |
dc.identifier.authority | Lai, CL=rp00314 | en_HK |
dc.identifier.authority | Wong, BCY=rp00429 | en_HK |
dc.identifier.authority | Fung, J=rp00518 | en_HK |
dc.identifier.authority | Yuen, MF=rp00479 | en_HK |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1111/j.1365-2036.2006.03029.x | en_HK |
dc.identifier.pmid | 16907890 | - |
dc.identifier.scopus | eid_2-s2.0-33746424431 | en_HK |
dc.identifier.hkuros | 130684 | en_HK |
dc.identifier.hkuros | 122176 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-33746424431&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 24 | en_HK |
dc.identifier.issue | 4 | en_HK |
dc.identifier.spage | 573 | en_HK |
dc.identifier.epage | 583 | en_HK |
dc.identifier.isi | WOS:000239306800002 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.identifier.scopusauthorid | Cheung, TK=7103334158 | en_HK |
dc.identifier.scopusauthorid | Lai, CL=7403086396 | en_HK |
dc.identifier.scopusauthorid | Wong, BCY=7402023340 | en_HK |
dc.identifier.scopusauthorid | Fung, J=23091109300 | en_HK |
dc.identifier.scopusauthorid | Yuen, MF=7102031955 | en_HK |
dc.identifier.citeulike | 775697 | - |
dc.identifier.issnl | 0269-2813 | - |