File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Clinical features, biochemical parameters, and virological profiles of patients with hepatocellular carcinoma in Hong Kong

TitleClinical features, biochemical parameters, and virological profiles of patients with hepatocellular carcinoma in Hong Kong
Authors
Issue Date2006
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APT
Citation
Alimentary Pharmacology And Therapeutics, 2006, v. 24 n. 4, p. 573-583 How to Cite?
AbstractBackground: Clinical features of hepatocellular carcinoma patients are changing because of screening. Aim: To examine the clinical features of hepatocellular carcinoma patients in Hong Kong and validity of different staging systems. Methods: A total of 223 Chinese patients with hepatocellular carcinoma were studied. Results: Seventy-eight percent of hepatocellular carcinoma patients had chronic hepatitis B (43% diagnosed by screening). Hepatitis B positivity, weight loss, jaundice, encephalopathy, alpha-fetoprotein level, portal vein thrombosis, extrahepatic metastasis, and treatment were shown to be independent factors affecting survival. Of chronic hepatitis B patients, hepatitis B virus DNA levels (P = 0.001) and portal vein thrombosis (P = 0.008) were independent factors affecting survival. Seventy-six percent of chronic hepatitis B patients with hepatocellular carcinoma were hepatitis B e antigen negative. Screening patients had hepatocellular carcinoma detected at an earlier stage and better survival (median survival: 21 vs. 4 months, P < 0.0001). All staging systems had good stratification of survival. Prognosis and median survival generated were different when compared with the US data. Conclusions: Chronic hepatitis B was the most common cause of hepatocellular carcinoma in Hong Kong. High-risk chronic hepatitis B patients should be followed irrespective of the hepatitis B e antigen status. Hepatitis B virus DNA levels at the time of diagnosis are an important survival predictor. Screening detected hepatocellular carcinoma at an earlier stage and prolonged survival. Staging systems should be validated in different populations. © 2006 The Authors.
Persistent Identifierhttp://hdl.handle.net/10722/77715
ISSN
2015 Impact Factor: 6.32
2015 SCImago Journal Rankings: 2.833
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, TKen_HK
dc.contributor.authorLai, CLen_HK
dc.contributor.authorWong, BCYen_HK
dc.contributor.authorFung, Jen_HK
dc.contributor.authorYuen, MFen_HK
dc.date.accessioned2010-09-06T07:34:56Z-
dc.date.available2010-09-06T07:34:56Z-
dc.date.issued2006en_HK
dc.identifier.citationAlimentary Pharmacology And Therapeutics, 2006, v. 24 n. 4, p. 573-583en_HK
dc.identifier.issn0269-2813en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77715-
dc.description.abstractBackground: Clinical features of hepatocellular carcinoma patients are changing because of screening. Aim: To examine the clinical features of hepatocellular carcinoma patients in Hong Kong and validity of different staging systems. Methods: A total of 223 Chinese patients with hepatocellular carcinoma were studied. Results: Seventy-eight percent of hepatocellular carcinoma patients had chronic hepatitis B (43% diagnosed by screening). Hepatitis B positivity, weight loss, jaundice, encephalopathy, alpha-fetoprotein level, portal vein thrombosis, extrahepatic metastasis, and treatment were shown to be independent factors affecting survival. Of chronic hepatitis B patients, hepatitis B virus DNA levels (P = 0.001) and portal vein thrombosis (P = 0.008) were independent factors affecting survival. Seventy-six percent of chronic hepatitis B patients with hepatocellular carcinoma were hepatitis B e antigen negative. Screening patients had hepatocellular carcinoma detected at an earlier stage and better survival (median survival: 21 vs. 4 months, P < 0.0001). All staging systems had good stratification of survival. Prognosis and median survival generated were different when compared with the US data. Conclusions: Chronic hepatitis B was the most common cause of hepatocellular carcinoma in Hong Kong. High-risk chronic hepatitis B patients should be followed irrespective of the hepatitis B e antigen status. Hepatitis B virus DNA levels at the time of diagnosis are an important survival predictor. Screening detected hepatocellular carcinoma at an earlier stage and prolonged survival. Staging systems should be validated in different populations. © 2006 The Authors.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APTen_HK
dc.relation.ispartofAlimentary Pharmacology and Therapeuticsen_HK
dc.rightsAlimentary Pharmacology and Therapeutics. Copyright © Blackwell Publishing Ltd.en_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshCarcinoma, Hepatocellular - ethnology - pathology - virologyen_HK
dc.subject.meshChina - ethnologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHepatitis B, Chronic - etiologyen_HK
dc.subject.meshHong Kong - epidemiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshSurvival Analysisen_HK
dc.titleClinical features, biochemical parameters, and virological profiles of patients with hepatocellular carcinoma in Hong Kongen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0269-2813&volume=24&issue=4&spage=573&epage=583&date=2006&atitle=Clinical+Features,+Biochemical+Parameters,+and+Virological+Profiles+of+Patients+with+Hepatocellular+Carcinoma+in+Hong+Kongen_HK
dc.identifier.emailLai, CL:hrmelcl@hku.hken_HK
dc.identifier.emailWong, BCY:bcywong@hku.hken_HK
dc.identifier.emailFung, J:jfung@sicklehut.comen_HK
dc.identifier.emailYuen, MF:mfyuen@hkucc.hku.hken_HK
dc.identifier.authorityLai, CL=rp00314en_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.identifier.authorityFung, J=rp00518en_HK
dc.identifier.authorityYuen, MF=rp00479en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1111/j.1365-2036.2006.03029.xen_HK
dc.identifier.pmid16907890-
dc.identifier.scopuseid_2-s2.0-33746424431en_HK
dc.identifier.hkuros130684en_HK
dc.identifier.hkuros122176-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33746424431&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume24en_HK
dc.identifier.issue4en_HK
dc.identifier.spage573en_HK
dc.identifier.epage583en_HK
dc.identifier.isiWOS:000239306800002-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridCheung, TK=7103334158en_HK
dc.identifier.scopusauthoridLai, CL=7403086396en_HK
dc.identifier.scopusauthoridWong, BCY=7402023340en_HK
dc.identifier.scopusauthoridFung, J=23091109300en_HK
dc.identifier.scopusauthoridYuen, MF=7102031955en_HK
dc.identifier.citeulike775697-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats