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Article: Mannose binding lectin gene mutations are associated with progression of liver disease in chronic: Hepatitis B infection

TitleMannose binding lectin gene mutations are associated with progression of liver disease in chronic: Hepatitis B infection
Authors
Issue Date1999
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.hepatology.org/
Citation
Hepatology, 1999, v. 29 n. 4, p. 1248-1251 How to Cite?
AbstractMannose-binding lectin (MBL) plays an important role in immune defense. We examined the MBL gene mutations and MBL levels in Chinese hepatitis B and hepatitis C patients with and without symptomatic cirrhosis. We recruited 190 hepatitis B and C patients, and 117 normal Chinese as controls. Serum MBL levels were measured by enzyme-linked immunosorbent assay. MBL gene mutation at codons 52, 54, and 57 was detected by polymerase chain reaction (PCR) assay. In asymptomatic hepatitis B and C patients, there was no increase in codons 52, 54, and 57 mutation, but the MBL levels were significantly lower than those in the controls. Codon 54 mutation rate was increased to 44.4% (P = .007) in symptomatic hepatitis B cirrhosis and 64.3% (P = .0026) in patients with spontaneous bacterial peritonitis (SBP). There was no increase in codon 54 mutation rate in hepatitis B-related hepatocellular carcinoma (HCC). In chronic hepatitis B infection, the odds ratio for an individual with codon 54 mutation to develop cirrhosis was 1.84 (95% CI: 1.21-2.81) and to develop SBP was 4.58 (95% CI: 1.73-12.16). Chronic hepatitis B and hepatitis C infection lowered the MBL levels, probably by suppressing MBL production. Codon 54 mutation of MBL was associated with progression of disease in chronic hepatitis B infection.
Persistent Identifierhttp://hdl.handle.net/10722/77678
ISSN
2015 Impact Factor: 11.711
2015 SCImago Journal Rankings: 4.752
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYuen, MFen_HK
dc.contributor.authorLau, CSen_HK
dc.contributor.authorLau, YULen_HK
dc.contributor.authorWong, WMen_HK
dc.contributor.authorCheng, CCen_HK
dc.contributor.authorLai, CLen_HK
dc.date.accessioned2010-09-06T07:34:31Z-
dc.date.available2010-09-06T07:34:31Z-
dc.date.issued1999en_HK
dc.identifier.citationHepatology, 1999, v. 29 n. 4, p. 1248-1251en_HK
dc.identifier.issn0270-9139en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77678-
dc.description.abstractMannose-binding lectin (MBL) plays an important role in immune defense. We examined the MBL gene mutations and MBL levels in Chinese hepatitis B and hepatitis C patients with and without symptomatic cirrhosis. We recruited 190 hepatitis B and C patients, and 117 normal Chinese as controls. Serum MBL levels were measured by enzyme-linked immunosorbent assay. MBL gene mutation at codons 52, 54, and 57 was detected by polymerase chain reaction (PCR) assay. In asymptomatic hepatitis B and C patients, there was no increase in codons 52, 54, and 57 mutation, but the MBL levels were significantly lower than those in the controls. Codon 54 mutation rate was increased to 44.4% (P = .007) in symptomatic hepatitis B cirrhosis and 64.3% (P = .0026) in patients with spontaneous bacterial peritonitis (SBP). There was no increase in codon 54 mutation rate in hepatitis B-related hepatocellular carcinoma (HCC). In chronic hepatitis B infection, the odds ratio for an individual with codon 54 mutation to develop cirrhosis was 1.84 (95% CI: 1.21-2.81) and to develop SBP was 4.58 (95% CI: 1.73-12.16). Chronic hepatitis B and hepatitis C infection lowered the MBL levels, probably by suppressing MBL production. Codon 54 mutation of MBL was associated with progression of disease in chronic hepatitis B infection.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.hepatology.org/en_HK
dc.relation.ispartofHepatologyen_HK
dc.rightsHepatology. Copyright © John Wiley & Sons, Inc.en_HK
dc.subject.meshCarcinoma, Hepatocellular - Blood - Complications - Genetics-
dc.subject.meshCarrier Proteins - Blood - Genetics-
dc.subject.meshEnzyme-Linked Immunosorbent Assay-
dc.subject.meshLiver Neoplasms - Blood - Complications - Genetics-
dc.subject.meshPeritonitis - Blood - Complications - Genetics-
dc.titleMannose binding lectin gene mutations are associated with progression of liver disease in chronic: Hepatitis B infectionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0270-9139&volume=29&spage=1248&epage=1251&date=1999&atitle=Mannose+binding+lectin+gene+mutations+are+associated+with+progression+of+liver+disease+in+chronic+hepatitis+B+infectionen_HK
dc.identifier.emailYuen, MF:mfyuen@hkucc.hku.hken_HK
dc.identifier.emailLau, CS:cslau@hku.hken_HK
dc.identifier.emailLau, YUL:lauylung@hkucc.hku.hken_HK
dc.identifier.emailLai, CL:hrmelcl@hku.hken_HK
dc.identifier.authorityYuen, MF=rp00479en_HK
dc.identifier.authorityLau, CS=rp01348en_HK
dc.identifier.authorityLau, YUL=rp00361en_HK
dc.identifier.authorityLai, CL=rp00314en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid10094971-
dc.identifier.scopuseid_2-s2.0-0032953750en_HK
dc.identifier.hkuros40862en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032953750&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume29en_HK
dc.identifier.issue4en_HK
dc.identifier.spage1248en_HK
dc.identifier.epage1251en_HK
dc.identifier.isiWOS:000079390500034-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridYuen, MF=7102031955en_HK
dc.identifier.scopusauthoridLau, CS=14035682100en_HK
dc.identifier.scopusauthoridLau, YUL=7201403380en_HK
dc.identifier.scopusauthoridWong, WM=7403972413en_HK
dc.identifier.scopusauthoridCheng, CC=7404796652en_HK
dc.identifier.scopusauthoridLai, CL=7403086396en_HK

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