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Article: Serum adiponectin is increased in advancing liver fibrosis and declines with reduction in fibrosis in chronic hepatitis B

TitleSerum adiponectin is increased in advancing liver fibrosis and declines with reduction in fibrosis in chronic hepatitis B
Authors
KeywordsAdiponectin
Adiponectin oligomeric form
Chronic hepatitis B
Lamivudine
Liver cirrhosis
Pegylated interferon alfa-2a
Sustained virological response
Issue Date2007
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jhep
Citation
Journal Of Hepatology, 2007, v. 47 n. 2, p. 191-202 How to Cite?
Abstract
Background/Aims: Despite the possible role of adiponectin in the pathogenesis of liver cirrhosis, few data have been collected from patients in different stages of liver fibrosis. We studied the role of adiponectin in 2 chronic hepatitis B (CHB)-patient cohorts. Methods: Serum adiponectin was quantified by enzyme-linked immunosorbent assay. One-hundred liver biopsy specimens from CHB patients with different stages of fibrosis and 38 paired liver biopsies from hepatitis B e antigen-positive patients randomized to lamivudine (n = 15), pegylated interferon alfa-2a (n = 15) or pegylated interferon alfa-2a plus lamivudine (n = 8) therapy for 48 weeks were assessed. Results: Serum adiponectin was detected at levels ranging over fourfold magnitude with advancing fibrosis stage and correlated positively with fibrosis stage [r = 0.45, p < 0.001]. CHB patients with stage 0-1 fibrosis had higher composition of high molecular weight (HMW) form of adiponectin when compared with CHB patients with liver cirrhosis [mean ± SEM 51.2 ± 2.1% vs. 40.9 ± 1.7%, respectively, p = 0.001]. After antiviral therapy, patients with fibrosis reduction had marked decline in serum adiponectin level and increase in HMW form of adiponectin [mean ± SEM 43.5 ± 1.2% vs. 37.0 ± 3.0%, respectively, p = 0.04]. Conclusions: Serum adiponectin may have a role in fibrosis progression in CHB infection. A marked decline in serum adiponectin after antiviral therapy is associated with fibrosis reduction. © 2007 European Association for the Study of the Liver.
Persistent Identifierhttp://hdl.handle.net/10722/77676
ISSN
2013 Impact Factor: 10.401
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHui, CKen_HK
dc.contributor.authorZhang, HYen_HK
dc.contributor.authorLee, NPen_HK
dc.contributor.authorChan, Wen_HK
dc.contributor.authorYueng, YHen_HK
dc.contributor.authorLeung, KWen_HK
dc.contributor.authorLu, Len_HK
dc.contributor.authorLeung, Nen_HK
dc.contributor.authorLo, CMen_HK
dc.contributor.authorFan, STen_HK
dc.contributor.authorLuk, JMen_HK
dc.contributor.authorXu, Aen_HK
dc.contributor.authorLam, KSen_HK
dc.contributor.authorKwong, YLen_HK
dc.contributor.authorLau, GKKen_HK
dc.date.accessioned2010-09-06T07:34:30Z-
dc.date.available2010-09-06T07:34:30Z-
dc.date.issued2007en_HK
dc.identifier.citationJournal Of Hepatology, 2007, v. 47 n. 2, p. 191-202en_HK
dc.identifier.issn0168-8278en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77676-
dc.description.abstractBackground/Aims: Despite the possible role of adiponectin in the pathogenesis of liver cirrhosis, few data have been collected from patients in different stages of liver fibrosis. We studied the role of adiponectin in 2 chronic hepatitis B (CHB)-patient cohorts. Methods: Serum adiponectin was quantified by enzyme-linked immunosorbent assay. One-hundred liver biopsy specimens from CHB patients with different stages of fibrosis and 38 paired liver biopsies from hepatitis B e antigen-positive patients randomized to lamivudine (n = 15), pegylated interferon alfa-2a (n = 15) or pegylated interferon alfa-2a plus lamivudine (n = 8) therapy for 48 weeks were assessed. Results: Serum adiponectin was detected at levels ranging over fourfold magnitude with advancing fibrosis stage and correlated positively with fibrosis stage [r = 0.45, p < 0.001]. CHB patients with stage 0-1 fibrosis had higher composition of high molecular weight (HMW) form of adiponectin when compared with CHB patients with liver cirrhosis [mean ± SEM 51.2 ± 2.1% vs. 40.9 ± 1.7%, respectively, p = 0.001]. After antiviral therapy, patients with fibrosis reduction had marked decline in serum adiponectin level and increase in HMW form of adiponectin [mean ± SEM 43.5 ± 1.2% vs. 37.0 ± 3.0%, respectively, p = 0.04]. Conclusions: Serum adiponectin may have a role in fibrosis progression in CHB infection. A marked decline in serum adiponectin after antiviral therapy is associated with fibrosis reduction. © 2007 European Association for the Study of the Liver.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jhepen_HK
dc.relation.ispartofJournal of Hepatologyen_HK
dc.rightsJournal of Hepatology. Copyright © Elsevier BV.en_HK
dc.subjectAdiponectinen_HK
dc.subjectAdiponectin oligomeric formen_HK
dc.subjectChronic hepatitis Ben_HK
dc.subjectLamivudineen_HK
dc.subjectLiver cirrhosisen_HK
dc.subjectPegylated interferon alfa-2aen_HK
dc.subjectSustained virological responseen_HK
dc.subject.meshAdiponectin - blood - chemistry - geneticsen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshAntiviral Agents - therapeutic useen_HK
dc.subject.meshCohort Studiesen_HK
dc.subject.meshDisease Progressionen_HK
dc.subject.meshEnzyme-Linked Immunosorbent Assayen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHepatitis B, Chronic - complications - drug therapy - pathologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshLiver - metabolismen_HK
dc.subject.meshLiver Cirrhosis - blood - metabolism - pathology - virologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshMolecular Weighten_HK
dc.subject.meshRNA, Messenger - metabolismen_HK
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen_HK
dc.subject.meshSeverity of Illness Indexen_HK
dc.titleSerum adiponectin is increased in advancing liver fibrosis and declines with reduction in fibrosis in chronic hepatitis Ben_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0168-8278&volume=47&issue=2&spage=191&epage=202&date=2007&atitle=Serum+adiponectin+is+increased+in+advancing+liver+fibrosis+and+declines+with+reduction+in+fibrosis+in+chronic+hepatitis+Ben_HK
dc.identifier.emailLee, NP: nikkilee@hku.hken_HK
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.emailLuk, JM: jmluk@hkucc.hku.hken_HK
dc.identifier.emailXu, A: amxu@hkucc.hku.hken_HK
dc.identifier.emailLam, KS: ksllam@hku.hken_HK
dc.identifier.emailKwong, YL: ylkwong@hku.hken_HK
dc.identifier.authorityLee, NP=rp00263en_HK
dc.identifier.authorityLo, CM=rp00412en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.identifier.authorityLuk, JM=rp00349en_HK
dc.identifier.authorityXu, A=rp00485en_HK
dc.identifier.authorityLam, KS=rp00343en_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jhep.2007.02.023en_HK
dc.identifier.pmid17462782en_HK
dc.identifier.scopuseid_2-s2.0-34347389866en_HK
dc.identifier.hkuros133098en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34347389866&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume47en_HK
dc.identifier.issue2en_HK
dc.identifier.spage191en_HK
dc.identifier.epage202en_HK
dc.identifier.isiWOS:000248642400006-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridHui, CK=35082057900en_HK
dc.identifier.scopusauthoridZhang, HY=8965962000en_HK
dc.identifier.scopusauthoridLee, NP=7402722690en_HK
dc.identifier.scopusauthoridChan, W=55040807500en_HK
dc.identifier.scopusauthoridYueng, YH=8965962100en_HK
dc.identifier.scopusauthoridLeung, KW=23097859100en_HK
dc.identifier.scopusauthoridLu, L=26326922300en_HK
dc.identifier.scopusauthoridLeung, N=26643107200en_HK
dc.identifier.scopusauthoridLo, CM=7401771672en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.scopusauthoridLuk, JM=7006777791en_HK
dc.identifier.scopusauthoridXu, A=7202655409en_HK
dc.identifier.scopusauthoridLam, KS=8082870600en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK
dc.identifier.scopusauthoridLau, GKK=7102301257en_HK

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