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Article: A short version of the ADAM questionnaire for androgen deficiency in Chinese men

TitleA short version of the ADAM questionnaire for androgen deficiency in Chinese men
Authors
KeywordsADAM questionnaire
Aging
Androgen deficiency
Chinese
Men
Testosterone
Issue Date2008
PublisherOxford University Press. The Journal's web site is located at http://biomed.gerontologyjournals.org/
Citation
Journals Of Gerontology - Series A Biological Sciences And Medical Sciences, 2008, v. 63 n. 4, p. 426-431 How to Cite?
AbstractBackground. A 10-question screening questionnaire for androgen deficiency in aging men (ADAM) was reported in previous white but not Chinese populations. We therefore investigated the validity of a Chinese version of the Saint Louis University ADAM questionnaire to screen for androgen deficiency in Chinese men. Methods. This was a cross-sectional study. Seven hundred ninety-six ambulatory community-based Chinese men, 18-89 years old, were recruited from October 2003 through June 2006. Self-administered Chinese ADAM questionnaire and morning blood samples for serum total testosterone (TT) and bioavailable testosterone (BT) levels were collected from all participants. Low serum BT levels (androgen deficiency) were defined as <5 th percentile of serum BT levels in young healthy Chinese men (18-29 years). Results. The Chinese ADAM questionnaire had good internal consistency (Cronbach α = 0.74) and test-retest reliability (Pearson correlation coefficient, r = 0.86; p < .001, two-tailed). As a screening test for low serum BT levels, the Chinese ADAM questionnaire has a high sensitivity of 88% but low specificity of 32%. In 6 of the 10 questions, the mean serum BT levels were significantly lower in those who answered positively than in those who answered negatively. Using a cut-off score of ≥2, a six-question short Chinese ADAM questionnaire demonstrated sensitivity, specificity, and positive and negative predictive values of 86%, 40%, 46%, and 82%, respectively. Conclusion. We have validated a full Chinese version and developed a shortened version of the ADAM questionnaire, and demonstrated that they are sensitive but not specific screening tests for androgen deficiency in Chinese men.
Persistent Identifierhttp://hdl.handle.net/10722/77655
ISSN
2015 Impact Factor: 5.476
2015 SCImago Journal Rankings: 2.675
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChu, LWen_HK
dc.contributor.authorTam, Sen_HK
dc.contributor.authorKung, AWCen_HK
dc.contributor.authorLam, TPen_HK
dc.contributor.authorLee, Aen_HK
dc.contributor.authorWong, RLCen_HK
dc.contributor.authorLo, Sen_HK
dc.contributor.authorFan, Sen_HK
dc.contributor.authorChung, CPen_HK
dc.contributor.authorMorley, JEen_HK
dc.contributor.authorLam, KSLen_HK
dc.date.accessioned2010-09-06T07:34:16Z-
dc.date.available2010-09-06T07:34:16Z-
dc.date.issued2008en_HK
dc.identifier.citationJournals Of Gerontology - Series A Biological Sciences And Medical Sciences, 2008, v. 63 n. 4, p. 426-431en_HK
dc.identifier.issn1079-5006en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77655-
dc.description.abstractBackground. A 10-question screening questionnaire for androgen deficiency in aging men (ADAM) was reported in previous white but not Chinese populations. We therefore investigated the validity of a Chinese version of the Saint Louis University ADAM questionnaire to screen for androgen deficiency in Chinese men. Methods. This was a cross-sectional study. Seven hundred ninety-six ambulatory community-based Chinese men, 18-89 years old, were recruited from October 2003 through June 2006. Self-administered Chinese ADAM questionnaire and morning blood samples for serum total testosterone (TT) and bioavailable testosterone (BT) levels were collected from all participants. Low serum BT levels (androgen deficiency) were defined as <5 th percentile of serum BT levels in young healthy Chinese men (18-29 years). Results. The Chinese ADAM questionnaire had good internal consistency (Cronbach α = 0.74) and test-retest reliability (Pearson correlation coefficient, r = 0.86; p < .001, two-tailed). As a screening test for low serum BT levels, the Chinese ADAM questionnaire has a high sensitivity of 88% but low specificity of 32%. In 6 of the 10 questions, the mean serum BT levels were significantly lower in those who answered positively than in those who answered negatively. Using a cut-off score of ≥2, a six-question short Chinese ADAM questionnaire demonstrated sensitivity, specificity, and positive and negative predictive values of 86%, 40%, 46%, and 82%, respectively. Conclusion. We have validated a full Chinese version and developed a shortened version of the ADAM questionnaire, and demonstrated that they are sensitive but not specific screening tests for androgen deficiency in Chinese men.en_HK
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://biomed.gerontologyjournals.org/en_HK
dc.relation.ispartofJournals of Gerontology - Series A Biological Sciences and Medical Sciencesen_HK
dc.subjectADAM questionnaireen_HK
dc.subjectAgingen_HK
dc.subjectAndrogen deficiencyen_HK
dc.subjectChineseen_HK
dc.subjectMenen_HK
dc.subjectTestosteroneen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshAge Factorsen_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshAndrogens - blood - deficiencyen_HK
dc.subject.meshAndropauseen_HK
dc.subject.meshAsian Continental Ancestry Group - statistics & numerical dataen_HK
dc.subject.meshCross-Cultural Comparisonen_HK
dc.subject.meshCross-Sectional Studiesen_HK
dc.subject.meshEuropean Continental Ancestry Group - statistics & numerical dataen_HK
dc.subject.meshHumansen_HK
dc.subject.meshHypogonadism - diagnosis - ethnologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMass Screeningen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPredictive Value of Testsen_HK
dc.subject.meshQuestionnairesen_HK
dc.subject.meshReproducibility of Resultsen_HK
dc.subject.meshTestosterone - blooden_HK
dc.titleA short version of the ADAM questionnaire for androgen deficiency in Chinese menen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0163-4372&volume=63&issue=4&spage=426&epage=431&date=2008&atitle=A+short+version+of+the+ADAM+questionnaire+for+androgen+deficiency+in+Chinese+men.+en_HK
dc.identifier.emailKung, AWC: awckung@hku.hken_HK
dc.identifier.emailLam, TP: tplam@hku.hken_HK
dc.identifier.emailLee, A: amlee@hkucc.hku.hken_HK
dc.identifier.emailLam, KSL: ksllam@hku.hken_HK
dc.identifier.authorityKung, AWC=rp00368en_HK
dc.identifier.authorityLam, TP=rp00386en_HK
dc.identifier.authorityLee, A=rp00483en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid18426968-
dc.identifier.scopuseid_2-s2.0-44349166805en_HK
dc.identifier.hkuros142442en_HK
dc.identifier.hkuros178245-
dc.identifier.hkuros242874-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-44349166805&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume63en_HK
dc.identifier.issue4en_HK
dc.identifier.spage426en_HK
dc.identifier.epage431en_HK
dc.identifier.isiWOS:000255426100012-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChu, LW=7202236665en_HK
dc.identifier.scopusauthoridTam, S=7202037323en_HK
dc.identifier.scopusauthoridKung, AWC=7102322339en_HK
dc.identifier.scopusauthoridLam, TP=55232643600en_HK
dc.identifier.scopusauthoridLee, A=7405629831en_HK
dc.identifier.scopusauthoridWong, RLC=37062742700en_HK
dc.identifier.scopusauthoridLo, S=8718876900en_HK
dc.identifier.scopusauthoridFan, S=11639038000en_HK
dc.identifier.scopusauthoridChung, CP=15847941600en_HK
dc.identifier.scopusauthoridMorley, JE=7403144221en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK

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