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- Publisher Website: 10.1111/j.1365-2265.2006.02710.x
- Scopus: eid_2-s2.0-33846185902
- PMID: 17223990
- WOS: WOS:000243441600009
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Article: Resistin gene polymorphisms and progression of glycaemia in southern Chinese: A 5-year prospective study
Title | Resistin gene polymorphisms and progression of glycaemia in southern Chinese: A 5-year prospective study |
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Authors | |
Issue Date | 2007 |
Publisher | Wiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0300-0664 |
Citation | Clinical Endocrinology, 2007, v. 66 n. 2, p. 211-217 How to Cite? |
Abstract | Objective: Human resistin gene (RETN) polymorphisms have been found to be associated with type 2 diabetes (T2DM), insulin resistance and/or obesity. We evaluated, in a 5-year prospective study, whether RETN polymorphisms could predict the progression of glycaemia in southern Chinese. Design and patients: We conducted a systematic search for variants in RETN in 70 southern Chinese subjects. This was followed by the genotyping in 624 unrelated nondiabetic subjects of two polymorphisms, -420C→G and +62G→A, previously reported in cross-sectional studies to be associated with T2DM in Asians, to examine their relationship with the progression of glycaemia in this cohort. Results: We identified 15 polymorphisms, including 2 novel but rare polymorphisms (-319G→A and +63G→C). Compared to subjects with the CC genotype, -420GG subjects had higher 2-h glucose (7.7 ± 1.8 vs. 7.2 ± 2.0 mmol/l, P = 0.011) and insulin (101.6 ± 69.5 vs. 79.8 ± 59.5 mU/l, P = 0.021) during an oral glucose tolerance test. Carriers of the +62A allele had higher body mass indices (25.3 ± 4.0 vs. 24.5 ± 3.6 kg/m 2 in GG, P = 0.02). The presence of the allele -420G (OR 2.15, 95% CI 1.28-3.60, P = 0.004) or +62A (OR1.86, 95% CI 1.08-3.21, P = 0.025) predicted the progression of glycaemia at Year 5, after adjustment for sex, age or body mass index. The haplotype G-A also conferred a higher risk of progression in glycaemia (P = 0.002). Conclusion: Our study would support the role of the resistin gene in obesity, insulin resistance and progression of glycaemia in southern Chinese. © 2006 The Authors. |
Persistent Identifier | http://hdl.handle.net/10722/77605 |
ISSN | 2023 Impact Factor: 3.0 2023 SCImago Journal Rankings: 0.978 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Xu, JY | en_HK |
dc.contributor.author | Sham, PC | en_HK |
dc.contributor.author | Xu, A | en_HK |
dc.contributor.author | Tso, AWK | en_HK |
dc.contributor.author | Wat, NMS | en_HK |
dc.contributor.author | Cheng, KY | en_HK |
dc.contributor.author | Fong, CHY | en_HK |
dc.contributor.author | Janus, ED | en_HK |
dc.contributor.author | Lam, KSL | en_HK |
dc.date.accessioned | 2010-09-06T07:33:43Z | - |
dc.date.available | 2010-09-06T07:33:43Z | - |
dc.date.issued | 2007 | en_HK |
dc.identifier.citation | Clinical Endocrinology, 2007, v. 66 n. 2, p. 211-217 | en_HK |
dc.identifier.issn | 0300-0664 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/77605 | - |
dc.description.abstract | Objective: Human resistin gene (RETN) polymorphisms have been found to be associated with type 2 diabetes (T2DM), insulin resistance and/or obesity. We evaluated, in a 5-year prospective study, whether RETN polymorphisms could predict the progression of glycaemia in southern Chinese. Design and patients: We conducted a systematic search for variants in RETN in 70 southern Chinese subjects. This was followed by the genotyping in 624 unrelated nondiabetic subjects of two polymorphisms, -420C→G and +62G→A, previously reported in cross-sectional studies to be associated with T2DM in Asians, to examine their relationship with the progression of glycaemia in this cohort. Results: We identified 15 polymorphisms, including 2 novel but rare polymorphisms (-319G→A and +63G→C). Compared to subjects with the CC genotype, -420GG subjects had higher 2-h glucose (7.7 ± 1.8 vs. 7.2 ± 2.0 mmol/l, P = 0.011) and insulin (101.6 ± 69.5 vs. 79.8 ± 59.5 mU/l, P = 0.021) during an oral glucose tolerance test. Carriers of the +62A allele had higher body mass indices (25.3 ± 4.0 vs. 24.5 ± 3.6 kg/m 2 in GG, P = 0.02). The presence of the allele -420G (OR 2.15, 95% CI 1.28-3.60, P = 0.004) or +62A (OR1.86, 95% CI 1.08-3.21, P = 0.025) predicted the progression of glycaemia at Year 5, after adjustment for sex, age or body mass index. The haplotype G-A also conferred a higher risk of progression in glycaemia (P = 0.002). Conclusion: Our study would support the role of the resistin gene in obesity, insulin resistance and progression of glycaemia in southern Chinese. © 2006 The Authors. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Wiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0300-0664 | en_HK |
dc.relation.ispartof | Clinical Endocrinology | en_HK |
dc.rights | Clinical Endocrinology. Copyright © Blackwell Publishing Ltd. | en_HK |
dc.subject.mesh | Adult | en_HK |
dc.subject.mesh | China | en_HK |
dc.subject.mesh | Disease Progression | en_HK |
dc.subject.mesh | Female | en_HK |
dc.subject.mesh | Gene Frequency | en_HK |
dc.subject.mesh | Genotype | en_HK |
dc.subject.mesh | Humans | en_HK |
dc.subject.mesh | Hyperglycemia - genetics | en_HK |
dc.subject.mesh | Insulin Resistance - genetics | en_HK |
dc.subject.mesh | Longitudinal Studies | en_HK |
dc.subject.mesh | Male | en_HK |
dc.subject.mesh | Middle Aged | en_HK |
dc.subject.mesh | Obesity - genetics | en_HK |
dc.subject.mesh | Polymorphism, Single Nucleotide | en_HK |
dc.subject.mesh | Prospective Studies | en_HK |
dc.subject.mesh | Resistin - genetics | en_HK |
dc.title | Resistin gene polymorphisms and progression of glycaemia in southern Chinese: A 5-year prospective study | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0300-0664&volume=66&spage=211&epage=7&date=2007&atitle=Resistin+gene+polymorphisms+and+progression+of+glycaemia+in+southern+Chinese:+a+5-year+prospective+study | en_HK |
dc.identifier.email | Sham, PC: pcsham@hku.hk | en_HK |
dc.identifier.email | Xu, A: amxu@hkucc.hku.hk | en_HK |
dc.identifier.email | Tso, AWK: awk.tso@gmail.com | en_HK |
dc.identifier.email | Cheng, KY: dorncky@hkucc.hku.hk | en_HK |
dc.identifier.email | Lam, KSL: ksllam@hku.hk | en_HK |
dc.identifier.authority | Sham, PC=rp00459 | en_HK |
dc.identifier.authority | Xu, A=rp00485 | en_HK |
dc.identifier.authority | Tso, AWK=rp00535 | en_HK |
dc.identifier.authority | Cheng, KY=rp01672 | en_HK |
dc.identifier.authority | Lam, KSL=rp00343 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1111/j.1365-2265.2006.02710.x | en_HK |
dc.identifier.pmid | 17223990 | - |
dc.identifier.scopus | eid_2-s2.0-33846185902 | en_HK |
dc.identifier.hkuros | 126068 | en_HK |
dc.identifier.hkuros | 151803 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-33846185902&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 66 | en_HK |
dc.identifier.issue | 2 | en_HK |
dc.identifier.spage | 211 | en_HK |
dc.identifier.epage | 217 | en_HK |
dc.identifier.isi | WOS:000243441600009 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.identifier.scopusauthorid | Xu, JY=8947805200 | en_HK |
dc.identifier.scopusauthorid | Sham, PC=34573429300 | en_HK |
dc.identifier.scopusauthorid | Xu, A=7202655409 | en_HK |
dc.identifier.scopusauthorid | Tso, AWK=6701371436 | en_HK |
dc.identifier.scopusauthorid | Wat, NMS=6602131754 | en_HK |
dc.identifier.scopusauthorid | Cheng, KY=7402997599 | en_HK |
dc.identifier.scopusauthorid | Fong, CHY=14033917100 | en_HK |
dc.identifier.scopusauthorid | Janus, ED=7006936536 | en_HK |
dc.identifier.scopusauthorid | Lam, KSL=8082870600 | en_HK |
dc.identifier.citeulike | 1048000 | - |
dc.identifier.issnl | 0300-0664 | - |