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Article: Surgical Treatment for Primary Hyperparathyroidism in Hong Kong: Changes in Clinical Pattern over 3 Decades
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TitleSurgical Treatment for Primary Hyperparathyroidism in Hong Kong: Changes in Clinical Pattern over 3 Decades
 
AuthorsLo, CY1
Chan, WF1
Kung, AWC1
Lam, KY1
Tam, SCF1
Lam, KSL1
Grant, C
 
Issue Date2004
 
PublisherAmerican Medical Association. The Journal's web site is located at http://www.archsurg.com
 
CitationArchives Of Surgery, 2004, v. 139 n. 1, p. 77-82 [How to Cite?]
DOI: http://dx.doi.org/10.1001/archsurg.139.1.77
 
AbstractHypothesis: With the introduction of the blood chemistry multichannel autoanalyzer, primary hyperparathyroidism (HPT) is increasingly diagnosed. The clinical pattern of primary HPT has undergone a significant evolution in Western countries. A similar change can be documented in a geographic region where this condition is considered to be relatively uncommon. Design: Unselected case series. Setting: A tertiary referral endocrine surgical unit. Patients: All patients with primary HPT surgically treated over the past 30 years. Main Outcome Measures: The prevalence of patients per 100000 hospital admissions, clinical presentation, biochemistry study results, pathologic status, and main outcome were compared over three 10-year spans according to the introduction of the multichannel autoanalyzer in 1982: 1973-1982 (n = 20), 1983-1992 (n = 31), and 1993-2002 (n = 190). Results: A 7-fold increase in the prevalence of patients with primary HPT who were surgically treated per 100 000 hospital admissions was observed over the past 10 years. The clinical presentation of patients with primary HPT had evolved progressively with a higher proportion of older patients (P<.001) being asymptomatic. On presentation, the condition had decreased in severity with lower serum calcium (P = .04), parathyroid hormone (P<.001), and alkaline phosphatase levels (P<.001) as well as a smaller adenoma size (P<.001). There was no significant change in the underlying pathologic condition and surgical success. Conclusion: Similar to the West but in contrast to that observed in other Asian countries, an increase in the prevalence of patients surgically treated for primary HPT is documented and a change in disease presentation as well as its severity is observed in our population group.
 
ISSN0004-0010
2012 Impact Factor: 4.1
 
DOIhttp://dx.doi.org/10.1001/archsurg.139.1.77
 
ISI Accession Number IDWOS:000187998500018
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLo, CY
 
dc.contributor.authorChan, WF
 
dc.contributor.authorKung, AWC
 
dc.contributor.authorLam, KY
 
dc.contributor.authorTam, SCF
 
dc.contributor.authorLam, KSL
 
dc.contributor.authorGrant, C
 
dc.date.accessioned2010-09-06T07:33:37Z
 
dc.date.available2010-09-06T07:33:37Z
 
dc.date.issued2004
 
dc.description.abstractHypothesis: With the introduction of the blood chemistry multichannel autoanalyzer, primary hyperparathyroidism (HPT) is increasingly diagnosed. The clinical pattern of primary HPT has undergone a significant evolution in Western countries. A similar change can be documented in a geographic region where this condition is considered to be relatively uncommon. Design: Unselected case series. Setting: A tertiary referral endocrine surgical unit. Patients: All patients with primary HPT surgically treated over the past 30 years. Main Outcome Measures: The prevalence of patients per 100000 hospital admissions, clinical presentation, biochemistry study results, pathologic status, and main outcome were compared over three 10-year spans according to the introduction of the multichannel autoanalyzer in 1982: 1973-1982 (n = 20), 1983-1992 (n = 31), and 1993-2002 (n = 190). Results: A 7-fold increase in the prevalence of patients with primary HPT who were surgically treated per 100 000 hospital admissions was observed over the past 10 years. The clinical presentation of patients with primary HPT had evolved progressively with a higher proportion of older patients (P<.001) being asymptomatic. On presentation, the condition had decreased in severity with lower serum calcium (P = .04), parathyroid hormone (P<.001), and alkaline phosphatase levels (P<.001) as well as a smaller adenoma size (P<.001). There was no significant change in the underlying pathologic condition and surgical success. Conclusion: Similar to the West but in contrast to that observed in other Asian countries, an increase in the prevalence of patients surgically treated for primary HPT is documented and a change in disease presentation as well as its severity is observed in our population group.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationArchives Of Surgery, 2004, v. 139 n. 1, p. 77-82 [How to Cite?]
DOI: http://dx.doi.org/10.1001/archsurg.139.1.77
 
dc.identifier.doihttp://dx.doi.org/10.1001/archsurg.139.1.77
 
dc.identifier.epage82
 
dc.identifier.hkuros85934
 
dc.identifier.isiWOS:000187998500018
 
dc.identifier.issn0004-0010
2012 Impact Factor: 4.1
 
dc.identifier.issue1
 
dc.identifier.openurl
 
dc.identifier.pmid14718281
 
dc.identifier.scopuseid_2-s2.0-0346998112
 
dc.identifier.spage77
 
dc.identifier.urihttp://hdl.handle.net/10722/77597
 
dc.identifier.volume139
 
dc.languageeng
 
dc.publisherAmerican Medical Association. The Journal's web site is located at http://www.archsurg.com
 
dc.publisher.placeUnited States
 
dc.relation.ispartofArchives of Surgery
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdult
 
dc.subject.meshAge Distribution
 
dc.subject.meshCohort Studies
 
dc.subject.meshFemale
 
dc.subject.meshHong Kong - epidemiology
 
dc.subject.meshHumans
 
dc.subject.meshHyperparathyroidism - diagnosis - epidemiology - surgery
 
dc.subject.meshIncidence
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshParathyroidectomy - methods - statistics & numerical data
 
dc.subject.meshPostoperative Complications - epidemiology
 
dc.subject.meshProbability
 
dc.subject.meshPrognosis
 
dc.subject.meshRetrospective Studies
 
dc.subject.meshRisk Assessment
 
dc.subject.meshSeverity of Illness Index
 
dc.subject.meshSex Distribution
 
dc.subject.meshTreatment Outcome
 
dc.titleSurgical Treatment for Primary Hyperparathyroidism in Hong Kong: Changes in Clinical Pattern over 3 Decades
 
dc.typeArticle
 
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<contributor.author>Tam, SCF</contributor.author>
<contributor.author>Lam, KSL</contributor.author>
<contributor.author>Grant, C</contributor.author>
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Author Affiliations
  1. The University of Hong Kong