Article: Surgical Treatment for Primary Hyperparathyroidism in Hong Kong: Changes in Clinical Pattern over 3 Decades

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TitleSurgical Treatment for Primary Hyperparathyroidism in Hong Kong: Changes in Clinical Pattern over 3 Decades
AuthorsLo, CY1
Chan, WF1
Kung, AWC1
Lam, KY1
Tam, SCF1
Lam, KSL1
Grant, C
Issue Date2004
PublisherAmerican Medical Association. The Journal's web site is located at http://www.archsurg.com
CitationArchives Of Surgery, 2004, v. 139 n. 1, p. 77-82 [How to Cite?]
DOI: http://dx.doi.org/10.1001/archsurg.139.1.77
AbstractHypothesis: With the introduction of the blood chemistry multichannel autoanalyzer, primary hyperparathyroidism (HPT) is increasingly diagnosed. The clinical pattern of primary HPT has undergone a significant evolution in Western countries. A similar change can be documented in a geographic region where this condition is considered to be relatively uncommon. Design: Unselected case series. Setting: A tertiary referral endocrine surgical unit. Patients: All patients with primary HPT surgically treated over the past 30 years. Main Outcome Measures: The prevalence of patients per 100000 hospital admissions, clinical presentation, biochemistry study results, pathologic status, and main outcome were compared over three 10-year spans according to the introduction of the multichannel autoanalyzer in 1982: 1973-1982 (n = 20), 1983-1992 (n = 31), and 1993-2002 (n = 190). Results: A 7-fold increase in the prevalence of patients with primary HPT who were surgically treated per 100 000 hospital admissions was observed over the past 10 years. The clinical presentation of patients with primary HPT had evolved progressively with a higher proportion of older patients (P<.001) being asymptomatic. On presentation, the condition had decreased in severity with lower serum calcium (P = .04), parathyroid hormone (P<.001), and alkaline phosphatase levels (P<.001) as well as a smaller adenoma size (P<.001). There was no significant change in the underlying pathologic condition and surgical success. Conclusion: Similar to the West but in contrast to that observed in other Asian countries, an increase in the prevalence of patients surgically treated for primary HPT is documented and a change in disease presentation as well as its severity is observed in our population group.
ISSN0004-0010
2011 Impact Factor: 4.239
2011 SCImago Journal Rankings: 0.301
DOIhttp://dx.doi.org/10.1001/archsurg.139.1.77
ISI Accession Number IDWOS:000187998500018
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorLo, CY
dc.contributor.authorChan, WF
dc.contributor.authorKung, AWC
dc.contributor.authorLam, KY
dc.contributor.authorTam, SCF
dc.contributor.authorLam, KSL
dc.contributor.authorGrant, C
dc.date.accessioned2010-09-06T07:33:37Z
dc.date.available2010-09-06T07:33:37Z
dc.date.issued2004
dc.description.abstractHypothesis: With the introduction of the blood chemistry multichannel autoanalyzer, primary hyperparathyroidism (HPT) is increasingly diagnosed. The clinical pattern of primary HPT has undergone a significant evolution in Western countries. A similar change can be documented in a geographic region where this condition is considered to be relatively uncommon. Design: Unselected case series. Setting: A tertiary referral endocrine surgical unit. Patients: All patients with primary HPT surgically treated over the past 30 years. Main Outcome Measures: The prevalence of patients per 100000 hospital admissions, clinical presentation, biochemistry study results, pathologic status, and main outcome were compared over three 10-year spans according to the introduction of the multichannel autoanalyzer in 1982: 1973-1982 (n = 20), 1983-1992 (n = 31), and 1993-2002 (n = 190). Results: A 7-fold increase in the prevalence of patients with primary HPT who were surgically treated per 100 000 hospital admissions was observed over the past 10 years. The clinical presentation of patients with primary HPT had evolved progressively with a higher proportion of older patients (P<.001) being asymptomatic. On presentation, the condition had decreased in severity with lower serum calcium (P = .04), parathyroid hormone (P<.001), and alkaline phosphatase levels (P<.001) as well as a smaller adenoma size (P<.001). There was no significant change in the underlying pathologic condition and surgical success. Conclusion: Similar to the West but in contrast to that observed in other Asian countries, an increase in the prevalence of patients surgically treated for primary HPT is documented and a change in disease presentation as well as its severity is observed in our population group.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationArchives Of Surgery, 2004, v. 139 n. 1, p. 77-82 [How to Cite?]
DOI: http://dx.doi.org/10.1001/archsurg.139.1.77
dc.identifier.doihttp://dx.doi.org/10.1001/archsurg.139.1.77
dc.identifier.epage82
dc.identifier.hkuros85934
dc.identifier.isiWOS:000187998500018
dc.identifier.issn0004-0010
2011 Impact Factor: 4.239
2011 SCImago Journal Rankings: 0.301
dc.identifier.issue1
dc.identifier.openurl
dc.identifier.pmid14718281
dc.identifier.scopuseid_2-s2.0-0346998112
dc.identifier.spage77
dc.identifier.urihttp://hdl.handle.net/10722/77597
dc.identifier.volume139
dc.languageeng
dc.publisherAmerican Medical Association. The Journal's web site is located at http://www.archsurg.com
dc.publisher.placeUnited States
dc.relation.ispartofArchives of Surgery
dc.relation.referencesReferences in Scopus
dc.subject.meshAdult
dc.subject.meshAge Distribution
dc.subject.meshCohort Studies
dc.subject.meshFemale
dc.subject.meshHong Kong - epidemiology
dc.subject.meshHumans
dc.subject.meshHyperparathyroidism - diagnosis - epidemiology - surgery
dc.subject.meshIncidence
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshParathyroidectomy - methods - statistics & numerical data
dc.subject.meshPostoperative Complications - epidemiology
dc.subject.meshProbability
dc.subject.meshPrognosis
dc.subject.meshRetrospective Studies
dc.subject.meshRisk Assessment
dc.subject.meshSeverity of Illness Index
dc.subject.meshSex Distribution
dc.subject.meshTreatment Outcome
dc.titleSurgical Treatment for Primary Hyperparathyroidism in Hong Kong: Changes in Clinical Pattern over 3 Decades
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong