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Article: Surgical Treatment for Primary Hyperparathyroidism in Hong Kong: Changes in Clinical Pattern over 3 Decades

TitleSurgical Treatment for Primary Hyperparathyroidism in Hong Kong: Changes in Clinical Pattern over 3 Decades
Authors
Issue Date2004
PublisherAmerican Medical Association. The Journal's web site is located at http://www.archsurg.com
Citation
Archives Of Surgery, 2004, v. 139 n. 1, p. 77-82 How to Cite?
AbstractHypothesis: With the introduction of the blood chemistry multichannel autoanalyzer, primary hyperparathyroidism (HPT) is increasingly diagnosed. The clinical pattern of primary HPT has undergone a significant evolution in Western countries. A similar change can be documented in a geographic region where this condition is considered to be relatively uncommon. Design: Unselected case series. Setting: A tertiary referral endocrine surgical unit. Patients: All patients with primary HPT surgically treated over the past 30 years. Main Outcome Measures: The prevalence of patients per 100000 hospital admissions, clinical presentation, biochemistry study results, pathologic status, and main outcome were compared over three 10-year spans according to the introduction of the multichannel autoanalyzer in 1982: 1973-1982 (n = 20), 1983-1992 (n = 31), and 1993-2002 (n = 190). Results: A 7-fold increase in the prevalence of patients with primary HPT who were surgically treated per 100 000 hospital admissions was observed over the past 10 years. The clinical presentation of patients with primary HPT had evolved progressively with a higher proportion of older patients (P<.001) being asymptomatic. On presentation, the condition had decreased in severity with lower serum calcium (P = .04), parathyroid hormone (P<.001), and alkaline phosphatase levels (P<.001) as well as a smaller adenoma size (P<.001). There was no significant change in the underlying pathologic condition and surgical success. Conclusion: Similar to the West but in contrast to that observed in other Asian countries, an increase in the prevalence of patients surgically treated for primary HPT is documented and a change in disease presentation as well as its severity is observed in our population group.
Persistent Identifierhttp://hdl.handle.net/10722/77597
ISSN
2014 Impact Factor: 4.926
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLo, CYen_HK
dc.contributor.authorChan, WFen_HK
dc.contributor.authorKung, AWCen_HK
dc.contributor.authorLam, KYen_HK
dc.contributor.authorTam, SCFen_HK
dc.contributor.authorLam, KSLen_HK
dc.contributor.authorGrant, Cen_HK
dc.date.accessioned2010-09-06T07:33:37Z-
dc.date.available2010-09-06T07:33:37Z-
dc.date.issued2004en_HK
dc.identifier.citationArchives Of Surgery, 2004, v. 139 n. 1, p. 77-82en_HK
dc.identifier.issn0004-0010en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77597-
dc.description.abstractHypothesis: With the introduction of the blood chemistry multichannel autoanalyzer, primary hyperparathyroidism (HPT) is increasingly diagnosed. The clinical pattern of primary HPT has undergone a significant evolution in Western countries. A similar change can be documented in a geographic region where this condition is considered to be relatively uncommon. Design: Unselected case series. Setting: A tertiary referral endocrine surgical unit. Patients: All patients with primary HPT surgically treated over the past 30 years. Main Outcome Measures: The prevalence of patients per 100000 hospital admissions, clinical presentation, biochemistry study results, pathologic status, and main outcome were compared over three 10-year spans according to the introduction of the multichannel autoanalyzer in 1982: 1973-1982 (n = 20), 1983-1992 (n = 31), and 1993-2002 (n = 190). Results: A 7-fold increase in the prevalence of patients with primary HPT who were surgically treated per 100 000 hospital admissions was observed over the past 10 years. The clinical presentation of patients with primary HPT had evolved progressively with a higher proportion of older patients (P<.001) being asymptomatic. On presentation, the condition had decreased in severity with lower serum calcium (P = .04), parathyroid hormone (P<.001), and alkaline phosphatase levels (P<.001) as well as a smaller adenoma size (P<.001). There was no significant change in the underlying pathologic condition and surgical success. Conclusion: Similar to the West but in contrast to that observed in other Asian countries, an increase in the prevalence of patients surgically treated for primary HPT is documented and a change in disease presentation as well as its severity is observed in our population group.en_HK
dc.languageengen_HK
dc.publisherAmerican Medical Association. The Journal's web site is located at http://www.archsurg.comen_HK
dc.relation.ispartofArchives of Surgeryen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAge Distributionen_HK
dc.subject.meshCohort Studiesen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHong Kong - epidemiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshHyperparathyroidism - diagnosis - epidemiology - surgeryen_HK
dc.subject.meshIncidenceen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshParathyroidectomy - methods - statistics & numerical dataen_HK
dc.subject.meshPostoperative Complications - epidemiologyen_HK
dc.subject.meshProbabilityen_HK
dc.subject.meshPrognosisen_HK
dc.subject.meshRetrospective Studiesen_HK
dc.subject.meshRisk Assessmenten_HK
dc.subject.meshSeverity of Illness Indexen_HK
dc.subject.meshSex Distributionen_HK
dc.subject.meshTreatment Outcomeen_HK
dc.titleSurgical Treatment for Primary Hyperparathyroidism in Hong Kong: Changes in Clinical Pattern over 3 Decadesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0004-0010&volume=139&issue=1&spage=77&epage=82&date=2004&atitle=Surgical+treatment+for+primary+hyperparathyroidism+in+Hong+Kong:+Changes+in+clinical+pattern+over+3+decadesen_HK
dc.identifier.emailKung, AWC:awckung@hku.hken_HK
dc.identifier.emailLam, KSL:ksllam@hku.hken_HK
dc.identifier.authorityKung, AWC=rp00368en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1001/archsurg.139.1.77en_HK
dc.identifier.pmid14718281en_HK
dc.identifier.scopuseid_2-s2.0-0346998112en_HK
dc.identifier.hkuros85934en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0346998112&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume139en_HK
dc.identifier.issue1en_HK
dc.identifier.spage77en_HK
dc.identifier.epage82en_HK
dc.identifier.isiWOS:000187998500018-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLo, CY=16417392800en_HK
dc.identifier.scopusauthoridChan, WF=7403918455en_HK
dc.identifier.scopusauthoridKung, AWC=7102322339en_HK
dc.identifier.scopusauthoridLam, KY=7403657165en_HK
dc.identifier.scopusauthoridTam, SCF=7202037323en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK
dc.identifier.scopusauthoridGrant, C=7402511422en_HK

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