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Article: Role of complement in tubulointerstitial injury from proteinuria

TitleRole of complement in tubulointerstitial injury from proteinuria
Authors
KeywordsComplement
Local synthesis
Proteinuria
Proximal tubular epithelial cell
Tubulointerstitial disease
Issue Date2002
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/KBR
Citation
Kidney And Blood Pressure Research, 2002, v. 25 n. 2, p. 120-126 How to Cite?
AbstractThe complement system is being increasingly implicated in the pathogenesis of progressive renal disease resulting from persistent proteinuria. It has recently been established that renal tubular cells can produce complement, activate complement, and respond to complement activation. Complement proteins that pass through the glomerular barrier along with other serum proteins in the proteinuric state may become activated at the tubular epithelial brush border, and lead to a cascade of events culminating in cell injury. Furthermore, nephrotic components in the urinary space may cause direct activation of the tubular cells to overexpress complement and contribute to local tissue injury. In this review, we will discuss the current evidence supporting a role for complement in the pathogenesis of progressive tubulointerstitial damage in the proteinuric state. The possibility of complement inhibition intervening in progressive tubulointerstitial injury due to proteinuric glomerular disease will also be considered. Copyright © 2002 S. Karger AG, Basel.
Persistent Identifierhttp://hdl.handle.net/10722/77530
ISSN
2015 Impact Factor: 2.908
2015 SCImago Journal Rankings: 0.574
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTang, Sen_HK
dc.contributor.authorLai, KNen_HK
dc.contributor.authorSacks, SHen_HK
dc.date.accessioned2010-09-06T07:32:54Z-
dc.date.available2010-09-06T07:32:54Z-
dc.date.issued2002en_HK
dc.identifier.citationKidney And Blood Pressure Research, 2002, v. 25 n. 2, p. 120-126en_HK
dc.identifier.issn1420-4096en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77530-
dc.description.abstractThe complement system is being increasingly implicated in the pathogenesis of progressive renal disease resulting from persistent proteinuria. It has recently been established that renal tubular cells can produce complement, activate complement, and respond to complement activation. Complement proteins that pass through the glomerular barrier along with other serum proteins in the proteinuric state may become activated at the tubular epithelial brush border, and lead to a cascade of events culminating in cell injury. Furthermore, nephrotic components in the urinary space may cause direct activation of the tubular cells to overexpress complement and contribute to local tissue injury. In this review, we will discuss the current evidence supporting a role for complement in the pathogenesis of progressive tubulointerstitial damage in the proteinuric state. The possibility of complement inhibition intervening in progressive tubulointerstitial injury due to proteinuric glomerular disease will also be considered. Copyright © 2002 S. Karger AG, Basel.en_HK
dc.languageengen_HK
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/KBRen_HK
dc.relation.ispartofKidney and Blood Pressure Researchen_HK
dc.rightsKidney and Blood Pressure Research. Copyright © S Karger AG.en_HK
dc.subjectComplementen_HK
dc.subjectLocal synthesisen_HK
dc.subjectProteinuriaen_HK
dc.subjectProximal tubular epithelial cellen_HK
dc.subjectTubulointerstitial diseaseen_HK
dc.subject.meshComplement System Proteins - biosynthesis - physiologyen_HK
dc.subject.meshDisease Progressionen_HK
dc.subject.meshHumansen_HK
dc.subject.meshNephritis, Interstitial - etiology - metabolism - physiopathologyen_HK
dc.subject.meshProteinuria - complications - physiopathologyen_HK
dc.titleRole of complement in tubulointerstitial injury from proteinuriaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1420-4096&volume=25&issue=2&spage=120&epage=126&date=2002&atitle=Role+of+complement+in+tubulointerstitial+injury+from+proteinuriaen_HK
dc.identifier.emailTang, S: scwtang@hku.hken_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.authorityTang, S=rp00480en_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1159/000063520en_HK
dc.identifier.pmid12077496en_HK
dc.identifier.scopuseid_2-s2.0-0036049313en_HK
dc.identifier.hkuros69583en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036049313&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume25en_HK
dc.identifier.issue2en_HK
dc.identifier.spage120en_HK
dc.identifier.epage126en_HK
dc.identifier.isiWOS:000176952200011-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridTang, S=7403437082en_HK
dc.identifier.scopusauthoridLai, KN=7402135706en_HK
dc.identifier.scopusauthoridSacks, SH=7103294121en_HK

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