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Article: Emergency living related liver transplantation for fulminant reactivation of hepatitis B virus after unrelated marrow transplantation

TitleEmergency living related liver transplantation for fulminant reactivation of hepatitis B virus after unrelated marrow transplantation
Authors
KeywordsHepatitis B virus
Living related donor
Marrow transplantation
Orthotopic liver transplantation
Issue Date2003
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CTR
Citation
Clinical Transplantation, 2003, v. 17 n. 2, p. 121-125 How to Cite?
AbstractWe report a unique case of emergency living related donor orthotopic liver transplantation (OLT) for late fulminant reactivation of hepatitis B virus (HBV) after matched unrelated bone marrow transplantation (BMT) for chronic myeloid leukemia (CML). Cessation of lamivudine after BMT for HBV positive patients may carry risks of late fatal HBV reactivation. Similar to fulminant HBV reactivation in the general population, OLT under resumption of lamivudine can be life saving. In our case, concomitantly molecular relapse of CML at the time of liver failure was also cleared by OLT, possibly via a 'liver-graft vs. leukemia' effect. Liver rejection (graft vs. graft disease) was mild due to inherent immunocompromise of the marrow graft. Hence BMT recipients in stable remission should not be denied the opportunity for life-saving solid organ transplantation. A choice of marrow and liver donors with innate HBV immunity may be needed to give the additional advantage of long-term HBV clearance.
Persistent Identifierhttp://hdl.handle.net/10722/77322
ISSN
2015 Impact Factor: 1.844
2015 SCImago Journal Rankings: 0.821
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAu, WYen_HK
dc.contributor.authorLau, GKKen_HK
dc.contributor.authorLie, AKWen_HK
dc.contributor.authorLiang, Ren_HK
dc.contributor.authorLo, CMen_HK
dc.contributor.authorFan, STen_HK
dc.contributor.authorLiu, CLen_HK
dc.contributor.authorHawkins, BRen_HK
dc.contributor.authorNg, IOLen_HK
dc.contributor.authorKwong, YLen_HK
dc.date.accessioned2010-09-06T07:30:39Z-
dc.date.available2010-09-06T07:30:39Z-
dc.date.issued2003en_HK
dc.identifier.citationClinical Transplantation, 2003, v. 17 n. 2, p. 121-125en_HK
dc.identifier.issn0902-0063en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77322-
dc.description.abstractWe report a unique case of emergency living related donor orthotopic liver transplantation (OLT) for late fulminant reactivation of hepatitis B virus (HBV) after matched unrelated bone marrow transplantation (BMT) for chronic myeloid leukemia (CML). Cessation of lamivudine after BMT for HBV positive patients may carry risks of late fatal HBV reactivation. Similar to fulminant HBV reactivation in the general population, OLT under resumption of lamivudine can be life saving. In our case, concomitantly molecular relapse of CML at the time of liver failure was also cleared by OLT, possibly via a 'liver-graft vs. leukemia' effect. Liver rejection (graft vs. graft disease) was mild due to inherent immunocompromise of the marrow graft. Hence BMT recipients in stable remission should not be denied the opportunity for life-saving solid organ transplantation. A choice of marrow and liver donors with innate HBV immunity may be needed to give the additional advantage of long-term HBV clearance.en_HK
dc.languageengen_HK
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CTRen_HK
dc.relation.ispartofClinical Transplantationen_HK
dc.subjectHepatitis B virusen_HK
dc.subjectLiving related donoren_HK
dc.subjectMarrow transplantationen_HK
dc.subjectOrthotopic liver transplantationen_HK
dc.subject.meshAdulten_HK
dc.subject.meshBone Marrow Transplantation - adverse effectsen_HK
dc.subject.meshEmergenciesen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHepatitis B - complications - etiologyen_HK
dc.subject.meshHepatitis B virusen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLeukemia, Myelogenous, Chronic, BCR-ABL Positive - therapyen_HK
dc.subject.meshLiver Failure - etiology - surgeryen_HK
dc.subject.meshLiver Transplantationen_HK
dc.subject.meshLiving Donorsen_HK
dc.titleEmergency living related liver transplantation for fulminant reactivation of hepatitis B virus after unrelated marrow transplantationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0902-0063&volume=17&issue=2&spage=121&epage=125&date=2003&atitle=Emergency+living+related+liver+transplantation+for+fulminant+reactivation+of+hepatitis+B+virus+after+unrelated+marrow+transplantationen_HK
dc.identifier.emailLiang, R: rliang@hku.hken_HK
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.emailNg, IOL: iolng@hkucc.hku.hken_HK
dc.identifier.emailKwong, YL: ylkwong@hku.hken_HK
dc.identifier.authorityLiang, R=rp00345en_HK
dc.identifier.authorityLo, CM=rp00412en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.identifier.authorityNg, IOL=rp00335en_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1034/j.1399-0012.2003.00022.xen_HK
dc.identifier.pmid12709077-
dc.identifier.scopuseid_2-s2.0-0038301998en_HK
dc.identifier.hkuros79381en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0038301998&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume17en_HK
dc.identifier.issue2en_HK
dc.identifier.spage121en_HK
dc.identifier.epage125en_HK
dc.identifier.isiWOS:000182449900007-
dc.publisher.placeDenmarken_HK
dc.identifier.scopusauthoridAu, WY=7202383089en_HK
dc.identifier.scopusauthoridLau, GKK=7102301257en_HK
dc.identifier.scopusauthoridLie, AKW=24284842400en_HK
dc.identifier.scopusauthoridLiang, R=26643224900en_HK
dc.identifier.scopusauthoridLo, CM=7401771672en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.scopusauthoridLiu, CL=36644272400en_HK
dc.identifier.scopusauthoridHawkins, BR=35944486200en_HK
dc.identifier.scopusauthoridNg, IOL=7102753722en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK

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