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Article: Circulating adipocyte-fatty acid binding protein levels predict the development of the metabolic syndrome: A 5-year prospective study

TitleCirculating adipocyte-fatty acid binding protein levels predict the development of the metabolic syndrome: A 5-year prospective study
Authors
KeywordsInflammation
Insulin
Lipids
Metabolism
Obesity
Issue Date2007
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://circ.ahajournals.org
Citation
Circulation, 2007, v. 115 n. 12, p. 1537-1543 How to Cite?
AbstractBACKGROUND - Adipocyte-fatty acid binding protein (A-FABP), a major cytoplasmic protein in adipocytes, plays a central role in the development of diabetes and atherosclerotic cardiovascular disease in experimental animals. We have previously shown that A-FABP is present in the bloodstream and that its circulating levels correlate with metabolic risk factors in a cross-sectional study. In the present study, we further evaluated the prospective association of A-FABP with the metabolic syndrome (MetS) as defined by the updated National Cholesterol Education Program criteria. METHODS AND RESULTS - In the present study, 495 nondiabetic adults from the population-based Hong Kong Cardiovascular Risk Factor Prevalence Study were prospectively followed up for 5 years. The relationship of serum A-FABP with the MetS and its components was investigated. At baseline, high A-FABP levels were associated with the MetS (odds ratio, 4.0; 95% CI, 1.5 to 10.4; highest versus lowest sex-specific tertile, adjusted for age, body mass index, the homeostasis model assessment index for insulin resistance, C-reactive protein, and adiponectin, P=0.005). On long-term follow-up, subjects with higher baseline A-FABP levels had progressively worse cardiometabolic risk profile and increasing risk of the MetS. Among 376 subjects without the MetS at baseline, 50 had developed it at 5 years. Apart from the homeostasis model assessment index for insulin resistance (P=0.001), baseline A-FABP was the only independent predictor of the development of the MetS during the 5-year follow-up (odds ratio, 4.7; 95% CI, 1.8 to 11.9; highest versus lowest sex-specific tertile, P=0.001, adjusted for the homeostasis model assessment index for insulin resistance and body mass index). A-FABP was predictive of the MetS even after adjustment for each of its individual components. CONCLUSIONS - Circulating A-FABP predicts the development of the MetS independently of adiposity and insulin resistance. © 2007 American Heart Association, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/77320
ISSN
2015 Impact Factor: 17.047
2015 SCImago Journal Rankings: 7.853
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorXu, Aen_HK
dc.contributor.authorTso, AWKen_HK
dc.contributor.authorCheung, BMYen_HK
dc.contributor.authorWang, Yen_HK
dc.contributor.authorWat, NMSen_HK
dc.contributor.authorFong, CHYen_HK
dc.contributor.authorYeung, DCYen_HK
dc.contributor.authorJanus, EDen_HK
dc.contributor.authorSham, PCen_HK
dc.contributor.authorLam, KSLen_HK
dc.date.accessioned2010-09-06T07:30:38Z-
dc.date.available2010-09-06T07:30:38Z-
dc.date.issued2007en_HK
dc.identifier.citationCirculation, 2007, v. 115 n. 12, p. 1537-1543en_HK
dc.identifier.issn0009-7322en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77320-
dc.description.abstractBACKGROUND - Adipocyte-fatty acid binding protein (A-FABP), a major cytoplasmic protein in adipocytes, plays a central role in the development of diabetes and atherosclerotic cardiovascular disease in experimental animals. We have previously shown that A-FABP is present in the bloodstream and that its circulating levels correlate with metabolic risk factors in a cross-sectional study. In the present study, we further evaluated the prospective association of A-FABP with the metabolic syndrome (MetS) as defined by the updated National Cholesterol Education Program criteria. METHODS AND RESULTS - In the present study, 495 nondiabetic adults from the population-based Hong Kong Cardiovascular Risk Factor Prevalence Study were prospectively followed up for 5 years. The relationship of serum A-FABP with the MetS and its components was investigated. At baseline, high A-FABP levels were associated with the MetS (odds ratio, 4.0; 95% CI, 1.5 to 10.4; highest versus lowest sex-specific tertile, adjusted for age, body mass index, the homeostasis model assessment index for insulin resistance, C-reactive protein, and adiponectin, P=0.005). On long-term follow-up, subjects with higher baseline A-FABP levels had progressively worse cardiometabolic risk profile and increasing risk of the MetS. Among 376 subjects without the MetS at baseline, 50 had developed it at 5 years. Apart from the homeostasis model assessment index for insulin resistance (P=0.001), baseline A-FABP was the only independent predictor of the development of the MetS during the 5-year follow-up (odds ratio, 4.7; 95% CI, 1.8 to 11.9; highest versus lowest sex-specific tertile, P=0.001, adjusted for the homeostasis model assessment index for insulin resistance and body mass index). A-FABP was predictive of the MetS even after adjustment for each of its individual components. CONCLUSIONS - Circulating A-FABP predicts the development of the MetS independently of adiposity and insulin resistance. © 2007 American Heart Association, Inc.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://circ.ahajournals.orgen_HK
dc.relation.ispartofCirculationen_HK
dc.rightsCirculation. Copyright © Lippincott Williams & Wilkins.en_HK
dc.subjectInflammationen_HK
dc.subjectInsulinen_HK
dc.subjectLipidsen_HK
dc.subjectMetabolismen_HK
dc.subjectObesityen_HK
dc.subject.meshAdipose Tissue - chemistryen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBlood Glucose - analysisen_HK
dc.subject.meshBody Mass Indexen_HK
dc.subject.meshCross-Sectional Studiesen_HK
dc.subject.meshFatty Acid-Binding Proteins - blooden_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFollow-Up Studiesen_HK
dc.subject.meshHomeostasisen_HK
dc.subject.meshHong Kong - epidemiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshHypertension - epidemiologyen_HK
dc.subject.meshHypertriglyceridemia - epidemiologyen_HK
dc.subject.meshInsulin Resistanceen_HK
dc.subject.meshLikelihood Functionsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMetabolic Syndrome X - blood - epidemiology - etiologyen_HK
dc.subject.meshMiceen_HK
dc.subject.meshMice, Inbred C57BLen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshModels, Biologicalen_HK
dc.subject.meshObesity - epidemiologyen_HK
dc.subject.meshOdds Ratioen_HK
dc.subject.meshProspective Studiesen_HK
dc.subject.meshRisk Factorsen_HK
dc.titleCirculating adipocyte-fatty acid binding protein levels predict the development of the metabolic syndrome: A 5-year prospective studyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0009-7322&volume=115&spage=1537&epage=43&date=2007&atitle=Circulating+adipocyte-fatty+acid+binding+protein+levels+predict+the+development+of+the+metabolic+syndrome:+a+5-year+prospective+studyen_HK
dc.identifier.emailXu, A: amxu@hkucc.hku.hken_HK
dc.identifier.emailTso, AWK: awk.tso@gmail.comen_HK
dc.identifier.emailCheung, BMY: mycheung@hku.hken_HK
dc.identifier.emailWang, Y: yuwanghk@hku.hken_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.emailLam, KSL: ksllam@hku.hken_HK
dc.identifier.authorityXu, A=rp00485en_HK
dc.identifier.authorityTso, AWK=rp00535en_HK
dc.identifier.authorityCheung, BMY=rp01321en_HK
dc.identifier.authorityWang, Y=rp00239en_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1161/CIRCULATIONAHA.106.647503en_HK
dc.identifier.pmid17389279-
dc.identifier.scopuseid_2-s2.0-34247472138en_HK
dc.identifier.hkuros129060en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34247472138&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume115en_HK
dc.identifier.issue12en_HK
dc.identifier.spage1537en_HK
dc.identifier.epage1543en_HK
dc.identifier.eissn1524-4539-
dc.identifier.isiWOS:000245211300006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridXu, A=7202655409en_HK
dc.identifier.scopusauthoridTso, AWK=6701371436en_HK
dc.identifier.scopusauthoridCheung, BMY=7103294806en_HK
dc.identifier.scopusauthoridWang, Y=34973733700en_HK
dc.identifier.scopusauthoridWat, NMS=6602131754en_HK
dc.identifier.scopusauthoridFong, CHY=14033917100en_HK
dc.identifier.scopusauthoridYeung, DCY=36869426200en_HK
dc.identifier.scopusauthoridJanus, ED=7006936536en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK

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