File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Precore and core promoter mutations at the time of HBeAg seroclearance in Chinese patients with chronic hepatitis B

TitlePrecore and core promoter mutations at the time of HBeAg seroclearance in Chinese patients with chronic hepatitis B
Authors
Issue Date2007
PublisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jinf
Citation
Journal Of Infection, 2007, v. 54 n. 5, p. 497-503 How to Cite?
AbstractObjective: To determine the prevalence of precore and core promoter (CP) mutations before, at and after HBeAg seroclearance in Chinese patients. Methods: Precore and CP mutations were determined in 93 patients with chronic hepatitis B 12-24 months before, at and 12 months after the time of HBeAg seroclearance. Results: No significant changes were found in the prevalence of precore or CP mutations before, at and after HBeAg seroclearance. Seven patients (7.8%) had HBeAg seroreversion within 1 year of HBeAg seroclearance. There was no significant difference in the prevalence of precore and CP mutations between patients with and without HBeAg seroreversion. 68.3% and 48.7% of patients harbored the same precore and CP genotypes throughout. 32.0% patients with precore mutations and 8.9% patients with CP mutations before HBeAg seroclearance had reversion to wild type within 1 year of HBeAg seroclearance. Patients with genotype C patients had a higher prevalence of CP mutations before HBeAg seroclearance compared with patients with genotype B (82.4% vs. 44%, P = 0.001). Conclusions: Precore and CP mutations existed in a substantial proportion of Chinese patients before HBeAg seroclearance. The replication of precore and, to a lesser extent, CP mutants could be suppressed around the time of HBeAg seroclearance. © 2006 The British Infection Society.
Persistent Identifierhttp://hdl.handle.net/10722/77283
ISSN
2015 Impact Factor: 4.382
2015 SCImago Journal Rankings: 2.070
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYuan, HJen_HK
dc.contributor.authorKaHo Wong, Den_HK
dc.contributor.authorDoutreloigne, Jen_HK
dc.contributor.authorSablon, Een_HK
dc.contributor.authorLai, CLen_HK
dc.contributor.authorYuen, MFen_HK
dc.date.accessioned2010-09-06T07:30:13Z-
dc.date.available2010-09-06T07:30:13Z-
dc.date.issued2007en_HK
dc.identifier.citationJournal Of Infection, 2007, v. 54 n. 5, p. 497-503en_HK
dc.identifier.issn0163-4453en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77283-
dc.description.abstractObjective: To determine the prevalence of precore and core promoter (CP) mutations before, at and after HBeAg seroclearance in Chinese patients. Methods: Precore and CP mutations were determined in 93 patients with chronic hepatitis B 12-24 months before, at and 12 months after the time of HBeAg seroclearance. Results: No significant changes were found in the prevalence of precore or CP mutations before, at and after HBeAg seroclearance. Seven patients (7.8%) had HBeAg seroreversion within 1 year of HBeAg seroclearance. There was no significant difference in the prevalence of precore and CP mutations between patients with and without HBeAg seroreversion. 68.3% and 48.7% of patients harbored the same precore and CP genotypes throughout. 32.0% patients with precore mutations and 8.9% patients with CP mutations before HBeAg seroclearance had reversion to wild type within 1 year of HBeAg seroclearance. Patients with genotype C patients had a higher prevalence of CP mutations before HBeAg seroclearance compared with patients with genotype B (82.4% vs. 44%, P = 0.001). Conclusions: Precore and CP mutations existed in a substantial proportion of Chinese patients before HBeAg seroclearance. The replication of precore and, to a lesser extent, CP mutants could be suppressed around the time of HBeAg seroclearance. © 2006 The British Infection Society.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jinfen_HK
dc.relation.ispartofJournal of Infectionen_HK
dc.subject.meshAdulten_HK
dc.subject.meshChinaen_HK
dc.subject.meshDNA, Viral - blooden_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHepatitis B Core Antigens - geneticsen_HK
dc.subject.meshHepatitis B e Antigens - blooden_HK
dc.subject.meshHepatitis B virus - genetics - immunology - isolation & purificationen_HK
dc.subject.meshHepatitis B, Chronic - virologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMutationen_HK
dc.subject.meshPromoter Regions, Geneticen_HK
dc.subject.meshProtein Precursors - geneticsen_HK
dc.titlePrecore and core promoter mutations at the time of HBeAg seroclearance in Chinese patients with chronic hepatitis Ben_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0163-4453&volume=54&spage=497&epage=503&date=2007&atitle=Precore+and+core+promoter+mutations+at+the+time+of+HBeAg+seroclearance+in+Chinese+patients+with+chronic+hepatitis+Ben_HK
dc.identifier.emailKaHo Wong, D:danywong@hku.hken_HK
dc.identifier.emailLai, CL:hrmelcl@hku.hken_HK
dc.identifier.emailYuen, MF:mfyuen@hkucc.hku.hken_HK
dc.identifier.authorityKaHo Wong, D=rp00492en_HK
dc.identifier.authorityLai, CL=rp00314en_HK
dc.identifier.authorityYuen, MF=rp00479en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jinf.2006.08.011en_HK
dc.identifier.pmid16997379-
dc.identifier.scopuseid_2-s2.0-34147148049en_HK
dc.identifier.hkuros130664en_HK
dc.identifier.hkuros131810-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34147148049&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume54en_HK
dc.identifier.issue5en_HK
dc.identifier.spage497en_HK
dc.identifier.epage503en_HK
dc.identifier.isiWOS:000246442900014-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridYuan, HJ=7402446707en_HK
dc.identifier.scopusauthoridKaHo Wong, D=7401535819en_HK
dc.identifier.scopusauthoridDoutreloigne, J=6603727456en_HK
dc.identifier.scopusauthoridSablon, E=6603694538en_HK
dc.identifier.scopusauthoridLai, CL=7403086396en_HK
dc.identifier.scopusauthoridYuen, MF=7102031955en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats