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Conference Paper: Immune response during immunoclearance phase of Chinese patients with HBV genotypes B and C

TitleImmune response during immunoclearance phase of Chinese patients with HBV genotypes B and C
Authors
Issue Date2005
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jhep
Citation
The 40th Annual Meeting of The European Association for the Study of the Liver, Paris, France, 13-17 April 2005. In Journal of Hepatology, 2005, v. 42 suppl. 2, p. 152, poster abstract no. 416 How to Cite?
AbstractBackground: Chronic hepatitis B patients with genotype B achieve HBeAg seroconversion at an earlier age compared with those with genotype C (Yuen et al., Hepatology 2003). Whether this is due to differences in tile immune response to file hepatitis B virus during the imrnunoclearance phase between patients with genotypes B and C has never been studied. Aims: To compare the immune response during the immunoclearance phase of patients with genotypes B and C. Patients and Methods: 20 HBeAg-positive patients with elevated ALT levels, 10 with genotype B and 10 with genotype C, were recruited. Proliferation and Till and Th2 immune responses of peripheral blood mononuclear cells were measured by 3H-thymidine uptake and ELISPOT assays respectively. The core promoter and precore mutations and HBV DNA levels were determined. Results: The followings are the interim results of first 12 patients (4 and 8 with genotypes B and C respectively). P values were not calculated because of the anlall number of patients. There were no differences in ALT and HBV DNA levels between two groups. Four patients with genotype B and 4 patients with genotype C had precore and core promoter mutations respectively. Compared to patients with genotype C, patients with genotype B had a higher stimulation index (proliferative response) towards HBcAg (4.6 vs. 2.7 respectively) and HBeAg (1.9 vs. 1.6 respectively). The results of tile ELISPOT assays are listed in the table. Conclusions: Compared to patients with genotype B, patients with genotype C have a lower proliferative response and greater induction of IL-10 production towards HBcAg and HBeAg. These phenomena may explain the delayed HBeAg seroconversion in patients with genotype C.
Persistent Identifierhttp://hdl.handle.net/10722/77228
ISSN
2015 Impact Factor: 10.59
2015 SCImago Journal Rankings: 4.570

 

DC FieldValueLanguage
dc.contributor.authorYuen, RMFen_HK
dc.contributor.authorWong, DKHen_HK
dc.contributor.authorChan, CCSen_HK
dc.contributor.authorZheng, BJen_HK
dc.contributor.authorYuen, JCHen_HK
dc.contributor.authorLai, CLen_HK
dc.date.accessioned2010-09-06T07:29:38Z-
dc.date.available2010-09-06T07:29:38Z-
dc.date.issued2005en_HK
dc.identifier.citationThe 40th Annual Meeting of The European Association for the Study of the Liver, Paris, France, 13-17 April 2005. In Journal of Hepatology, 2005, v. 42 suppl. 2, p. 152, poster abstract no. 416en_HK
dc.identifier.issn0168-8278en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77228-
dc.description.abstractBackground: Chronic hepatitis B patients with genotype B achieve HBeAg seroconversion at an earlier age compared with those with genotype C (Yuen et al., Hepatology 2003). Whether this is due to differences in tile immune response to file hepatitis B virus during the imrnunoclearance phase between patients with genotypes B and C has never been studied. Aims: To compare the immune response during the immunoclearance phase of patients with genotypes B and C. Patients and Methods: 20 HBeAg-positive patients with elevated ALT levels, 10 with genotype B and 10 with genotype C, were recruited. Proliferation and Till and Th2 immune responses of peripheral blood mononuclear cells were measured by 3H-thymidine uptake and ELISPOT assays respectively. The core promoter and precore mutations and HBV DNA levels were determined. Results: The followings are the interim results of first 12 patients (4 and 8 with genotypes B and C respectively). P values were not calculated because of the anlall number of patients. There were no differences in ALT and HBV DNA levels between two groups. Four patients with genotype B and 4 patients with genotype C had precore and core promoter mutations respectively. Compared to patients with genotype C, patients with genotype B had a higher stimulation index (proliferative response) towards HBcAg (4.6 vs. 2.7 respectively) and HBeAg (1.9 vs. 1.6 respectively). The results of tile ELISPOT assays are listed in the table. Conclusions: Compared to patients with genotype B, patients with genotype C have a lower proliferative response and greater induction of IL-10 production towards HBcAg and HBeAg. These phenomena may explain the delayed HBeAg seroconversion in patients with genotype C.-
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jhepen_HK
dc.relation.ispartofJournal of Hepatologyen_HK
dc.rightsJournal of Hepatology. Copyright © Elsevier BV.en_HK
dc.titleImmune response during immunoclearance phase of Chinese patients with HBV genotypes B and Cen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0168-8278&volume=42 &issue=Suppl 2&spage=152&epage=&date=2005&atitle=Immune+Response+During+Immunoclearance+Phase+of+Chinese+Patients+with+HBV+Genotypes+B+and+Cen_HK
dc.identifier.emailYuen, RMF: mfyuen@hkucc.hku.hken_HK
dc.identifier.emailWong, DKH: danwong@hkusua.hku.hken_HK
dc.identifier.emailChan, CCS: cschan@hkucc.hku.hken_HK
dc.identifier.emailZheng, BJ: bzheng@hkucc.hku.hk, gpzheng@hkucc.hku.hken_HK
dc.identifier.emailYuen, JCH: jchyuen@HKUCC.hku.hken_HK
dc.identifier.emailLai, CL: hrmelcl@hku.hken_HK
dc.identifier.authorityYuen, RMF=rp00479en_HK
dc.identifier.authorityWong, DKH=rp00492en_HK
dc.identifier.authorityZheng, BJ=rp00353en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0168-8278(05)81828-8-
dc.identifier.hkuros98466en_HK
dc.identifier.hkuros122632-
dc.identifier.volume42-
dc.identifier.issueSuppl. 2-
dc.identifier.spage152-
dc.identifier.epage152-
dc.publisher.placeThe Netherlands-
dc.description.otherThe 40th Annual Meeting of The European Association for the Study of the Liver, Paris, France, 13-17 April 2005 . In Journal of Hepatology, 2005, v. 42 n. Suppl. 2, p. 152, poster abstract no. 416-

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