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Article: Does withholding aspirin for one week reduce the risk of post-sphincterotomy bleeding?

TitleDoes withholding aspirin for one week reduce the risk of post-sphincterotomy bleeding?
Authors
Issue Date2002
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APT
Citation
Alimentary Pharmacology And Therapeutics, 2002, v. 16 n. 5, p. 929-936 How to Cite?
AbstractBackground: Complications of endoscopic sphincterotomy are closely related to the endoscopic technique. To date, there have been no studies to indicate that aspirin increases the risk of bleeding after endoscopic sphincterotomy. Aim: To compare the incidence of post-sphincterotomy bleeding in patients with and without prior aspirin therapy. Methods: Eight hundred and four patients were recruited into this retrospective study: 124 patients continued to take aspirin until the day of sphincterotomy (Group 1), 116 patients had their aspirin discontinued for 1 week before sphincterotomy (Group 2) and 564 patients had never taken aspirin (Group 3). The primary outcome analysed was the incidence of post-sphincterotomy bleeding. Results: Sixty-seven patients (8.3%) developed post-sphincterotomy bleeding. The incidences of post-sphincterotomy bleeding in Groups 1, 2 and 3 were 9.7%. 9.5% and 3.9%, respectively. Group 1 showed significantly increased post-sphincterotomy bleeding when compared with Group 3 (P = 0.01), and the risk was also significantly increased when Group 2 was compared with Group 3 (P = 0.01). However, there was no significant difference in post-sphincterotomy bleeding between Groups 1 and 2 (P = 0.96). Conclusions: Aspirin therapy increased the risk of post-sphincterotomy bleeding. Withholding aspirin for I week before endoscopic sphincterotomy did not seem to decrease the risk of post-sphincterotomy bleeding.
Persistent Identifierhttp://hdl.handle.net/10722/77209
ISSN
2015 Impact Factor: 6.32
2015 SCImago Journal Rankings: 2.833
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHui, CKen_HK
dc.contributor.authorLai, KCen_HK
dc.contributor.authorYuen, MFen_HK
dc.contributor.authorWong, WMen_HK
dc.contributor.authorLam, SKen_HK
dc.contributor.authorLai, CLen_HK
dc.date.accessioned2010-09-06T07:29:26Z-
dc.date.available2010-09-06T07:29:26Z-
dc.date.issued2002en_HK
dc.identifier.citationAlimentary Pharmacology And Therapeutics, 2002, v. 16 n. 5, p. 929-936en_HK
dc.identifier.issn0269-2813en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77209-
dc.description.abstractBackground: Complications of endoscopic sphincterotomy are closely related to the endoscopic technique. To date, there have been no studies to indicate that aspirin increases the risk of bleeding after endoscopic sphincterotomy. Aim: To compare the incidence of post-sphincterotomy bleeding in patients with and without prior aspirin therapy. Methods: Eight hundred and four patients were recruited into this retrospective study: 124 patients continued to take aspirin until the day of sphincterotomy (Group 1), 116 patients had their aspirin discontinued for 1 week before sphincterotomy (Group 2) and 564 patients had never taken aspirin (Group 3). The primary outcome analysed was the incidence of post-sphincterotomy bleeding. Results: Sixty-seven patients (8.3%) developed post-sphincterotomy bleeding. The incidences of post-sphincterotomy bleeding in Groups 1, 2 and 3 were 9.7%. 9.5% and 3.9%, respectively. Group 1 showed significantly increased post-sphincterotomy bleeding when compared with Group 3 (P = 0.01), and the risk was also significantly increased when Group 2 was compared with Group 3 (P = 0.01). However, there was no significant difference in post-sphincterotomy bleeding between Groups 1 and 2 (P = 0.96). Conclusions: Aspirin therapy increased the risk of post-sphincterotomy bleeding. Withholding aspirin for I week before endoscopic sphincterotomy did not seem to decrease the risk of post-sphincterotomy bleeding.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APTen_HK
dc.relation.ispartofAlimentary Pharmacology and Therapeuticsen_HK
dc.rightsAlimentary Pharmacology and Therapeutics. Copyright © Blackwell Publishing Ltd.en_HK
dc.subject.meshAgeden_HK
dc.subject.meshAnti-Inflammatory Agents, Non-Steroidal - administration & dosage - adverse effectsen_HK
dc.subject.meshAspirin - administration & dosage - adverse effectsen_HK
dc.subject.meshComorbidityen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshIncidenceen_HK
dc.subject.meshMaleen_HK
dc.subject.meshPostoperative Complicationsen_HK
dc.subject.meshPostoperative Hemorrhage - chemically induced - prevention & controlen_HK
dc.subject.meshRetrospective Studiesen_HK
dc.subject.meshRisk Factorsen_HK
dc.subject.meshSphincterotomy, Endoscopicen_HK
dc.titleDoes withholding aspirin for one week reduce the risk of post-sphincterotomy bleeding?en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0269-2813&volume=16&issue=5&spage=929&epage=936&date=2002&atitle=Does+withholding+aspirin+for+one+week+reduce+the+risk+of+post-sphincterotomy+bleeding?en_HK
dc.identifier.emailYuen, MF:mfyuen@hkucc.hku.hken_HK
dc.identifier.emailLai, CL:hrmelcl@hku.hken_HK
dc.identifier.authorityYuen, MF=rp00479en_HK
dc.identifier.authorityLai, CL=rp00314en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1046/j.1365-2036.2002.01251.xen_HK
dc.identifier.pmid11966501-
dc.identifier.scopuseid_2-s2.0-0036241188en_HK
dc.identifier.hkuros66972en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036241188&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume16en_HK
dc.identifier.issue5en_HK
dc.identifier.spage929en_HK
dc.identifier.epage936en_HK
dc.identifier.isiWOS:000175411100010-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridHui, CK=7202876933en_HK
dc.identifier.scopusauthoridLai, KC=7402135595en_HK
dc.identifier.scopusauthoridYuen, MF=7102031955en_HK
dc.identifier.scopusauthoridWong, WM=7403972413en_HK
dc.identifier.scopusauthoridLam, SK=7402279473en_HK
dc.identifier.scopusauthoridLai, CL=7403086396en_HK

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