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Article: Immunogenicity of intradermal hepatitis B vaccination in renal transplant recipients

TitleImmunogenicity of intradermal hepatitis B vaccination in renal transplant recipients
Authors
KeywordsHepatitis B vaccine
Immunogenicity
Intradermal
Transplant
Issue Date2002
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/AJT
Citation
American Journal Of Transplantation, 2002, v. 2 n. 10, p. 965-969 How to Cite?
AbstractWe investigated intradermal hepatitis B (HBV) vaccination in 24 renal transplant recipients who failed to develop hepatitis B surface antibody (anti-HBs) with intramuscular (i.m.) vaccination. All patients received recombinant HBV vaccine 5μg intradermally every 2weeks for 8 doses. Nine patients developed protective levels of anti-HBs (> 10 miu/mL) and two patients developed low levels of anti-HBs (4-6 miu/mL), giving an overall initial response rate of 45.8%. A booster of 40μg was administered intramuscularly after 1 year. All initial responders developed an anti-HBs response (322.6±92.0 miu/mL). In addition, four patients who did not respond initially to the intradermal vaccination seroconverted after the booster. Responders (62.5%) and nonresponders had comparable age, gender, immunosuppressive medications, and duration of transplant. In conclusion, renal transplant patients who fail to respond to intramuscular HBV vaccination may benefit from intradermal vaccination followed by an intramuscular booster.
Persistent Identifierhttp://hdl.handle.net/10722/77146
ISSN
2015 Impact Factor: 5.669
2015 SCImago Journal Rankings: 2.792
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChoy, BYen_HK
dc.contributor.authorPeiris, JSMen_HK
dc.contributor.authorChan, TMen_HK
dc.contributor.authorLo, SKFen_HK
dc.contributor.authorLui, SLen_HK
dc.contributor.authorLai, KNen_HK
dc.date.accessioned2010-09-06T07:28:46Z-
dc.date.available2010-09-06T07:28:46Z-
dc.date.issued2002en_HK
dc.identifier.citationAmerican Journal Of Transplantation, 2002, v. 2 n. 10, p. 965-969en_HK
dc.identifier.issn1600-6135en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77146-
dc.description.abstractWe investigated intradermal hepatitis B (HBV) vaccination in 24 renal transplant recipients who failed to develop hepatitis B surface antibody (anti-HBs) with intramuscular (i.m.) vaccination. All patients received recombinant HBV vaccine 5μg intradermally every 2weeks for 8 doses. Nine patients developed protective levels of anti-HBs (> 10 miu/mL) and two patients developed low levels of anti-HBs (4-6 miu/mL), giving an overall initial response rate of 45.8%. A booster of 40μg was administered intramuscularly after 1 year. All initial responders developed an anti-HBs response (322.6±92.0 miu/mL). In addition, four patients who did not respond initially to the intradermal vaccination seroconverted after the booster. Responders (62.5%) and nonresponders had comparable age, gender, immunosuppressive medications, and duration of transplant. In conclusion, renal transplant patients who fail to respond to intramuscular HBV vaccination may benefit from intradermal vaccination followed by an intramuscular booster.en_HK
dc.languageengen_HK
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/AJTen_HK
dc.relation.ispartofAmerican Journal of Transplantationen_HK
dc.subjectHepatitis B vaccineen_HK
dc.subjectImmunogenicityen_HK
dc.subjectIntradermalen_HK
dc.subjectTransplanten_HK
dc.subject.meshAdulten_HK
dc.subject.meshDrug Administration Scheduleen_HK
dc.subject.meshDrug Therapy, Combinationen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHepatitis B - epidemiology - prevention & controlen_HK
dc.subject.meshHepatitis B Antibodies - blooden_HK
dc.subject.meshHepatitis B Surface Antigens - immunologyen_HK
dc.subject.meshHepatitis B Vaccines - administration & dosage - immunologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunization, Secondaryen_HK
dc.subject.meshImmunosuppressive Agents - therapeutic useen_HK
dc.subject.meshInjections, Intradermalen_HK
dc.subject.meshKidney Failure, Chronic - etiology - surgeryen_HK
dc.subject.meshKidney Transplantation - immunologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshMorbidityen_HK
dc.subject.meshTime Factorsen_HK
dc.titleImmunogenicity of intradermal hepatitis B vaccination in renal transplant recipientsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1600-6135&volume=2&spage=965&epage=969&date=2002&atitle=Immunogenicity+of+intradermal+hepatitis+B+vaccination+in+renal+transplant+recipientsen_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_HK
dc.identifier.emailChan, TM: dtmchan@hku.hken_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.identifier.authorityChan, TM=rp00394en_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1034/j.1600-6143.2002.21014.xen_HK
dc.identifier.pmid12482150-
dc.identifier.scopuseid_2-s2.0-0344837776en_HK
dc.identifier.hkuros79058en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0344837776&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume2en_HK
dc.identifier.issue10en_HK
dc.identifier.spage965en_HK
dc.identifier.epage969en_HK
dc.identifier.isiWOS:000179564100014-
dc.publisher.placeDenmarken_HK
dc.identifier.scopusauthoridChoy, BY=7003465499en_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK
dc.identifier.scopusauthoridChan, TM=7402687700en_HK
dc.identifier.scopusauthoridLo, SKF=7401542391en_HK
dc.identifier.scopusauthoridLui, SL=7102379130en_HK
dc.identifier.scopusauthoridLai, KN=7402135706en_HK

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