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Article: Polymorphisms of the gene encoding adiponectin and glycaemic outcome of Chinese subjects with impaired glucose tolerance: A 5-year follow-up study

TitlePolymorphisms of the gene encoding adiponectin and glycaemic outcome of Chinese subjects with impaired glucose tolerance: A 5-year follow-up study
Authors
KeywordsAdiponectin
Diabetes
Gene
Hyperglycaemia
IGT
Impaired glucose tolerance
Single-nucleotide polymorphism
Issue Date2006
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00125/index.htm
Citation
Diabetologia, 2006, v. 49 n. 8, p. 1806-1815 How to Cite?
AbstractAims/hypothesis: Polymorphisms of the gene encoding adiponectin (ADIPOQ) have previously been associated with type 2 diabetes in Europid and Japanese subjects, but not in Pima Indians. The aim of this study was to determine the contribution made by ADIPOQ gene variants to glycaemic status in southern Chinese individuals. Subjects and methods: Sixty unrelated subjects were screened for single-nucleotide polymorphisms (SNPs) in the ADIPOQ gene by direct sequencing. The association of tagging SNPs with the outcome of glycaemic status in 262 subjects with impaired glucose tolerance (IGT) was examined in a 5-year prospective study. Results: We identified 15 polymorphisms in the ADIPOQ gene, ten of them constituting the tagging SNPs. At 5 years, 39.7% of the subjects with IGT had regressed to NGT, 41.2% had persistent IGT or impaired fasting glucose and 19.1% had developed diabetes. Only the T45G polymorphism was associated with persistent hyperglycaemia at 5 years (p=0.001). Haplotypes formed by the addition of other SNPs, as haplotype blocks or pairs, did not confer greater association than T45G alone. On logistic regression analysis, T45G independently predicted persistent hyperglycaemia at 5 years (OR=2.25, 95% CI 1.29-3.95, G carriers vs TT; p=0.005). It also predicted persistent hyperglycaemia in a nested case-control study involving 158 sex- and age-matched controls with persistent NGT (p=0.012, adjusted for BMI), and that of diabetes or glycaemia progression (p<0.05) in a meta-analysis that also included two published studies in Europid subjects. Conclusions/interpretation: Our findings support a significant role of this common ADIPOQ gene polymorphism in predicting glycaemic status in southern Chinese people. © Springer-Verlag 2006.
Persistent Identifierhttp://hdl.handle.net/10722/77144
ISSN
2015 Impact Factor: 6.206
2015 SCImago Journal Rankings: 3.528
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTso, AWKen_HK
dc.contributor.authorSham, PCen_HK
dc.contributor.authorWat, NMSen_HK
dc.contributor.authorXu, Aen_HK
dc.contributor.authorCheung, BMYen_HK
dc.contributor.authorRong, Ren_HK
dc.contributor.authorFong, CHYen_HK
dc.contributor.authorXu, JYen_HK
dc.contributor.authorCheng, KKYen_HK
dc.contributor.authorJanus, EDen_HK
dc.contributor.authorLam, KSLen_HK
dc.date.accessioned2010-09-06T07:28:45Z-
dc.date.available2010-09-06T07:28:45Z-
dc.date.issued2006en_HK
dc.identifier.citationDiabetologia, 2006, v. 49 n. 8, p. 1806-1815en_HK
dc.identifier.issn0012-186Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/77144-
dc.description.abstractAims/hypothesis: Polymorphisms of the gene encoding adiponectin (ADIPOQ) have previously been associated with type 2 diabetes in Europid and Japanese subjects, but not in Pima Indians. The aim of this study was to determine the contribution made by ADIPOQ gene variants to glycaemic status in southern Chinese individuals. Subjects and methods: Sixty unrelated subjects were screened for single-nucleotide polymorphisms (SNPs) in the ADIPOQ gene by direct sequencing. The association of tagging SNPs with the outcome of glycaemic status in 262 subjects with impaired glucose tolerance (IGT) was examined in a 5-year prospective study. Results: We identified 15 polymorphisms in the ADIPOQ gene, ten of them constituting the tagging SNPs. At 5 years, 39.7% of the subjects with IGT had regressed to NGT, 41.2% had persistent IGT or impaired fasting glucose and 19.1% had developed diabetes. Only the T45G polymorphism was associated with persistent hyperglycaemia at 5 years (p=0.001). Haplotypes formed by the addition of other SNPs, as haplotype blocks or pairs, did not confer greater association than T45G alone. On logistic regression analysis, T45G independently predicted persistent hyperglycaemia at 5 years (OR=2.25, 95% CI 1.29-3.95, G carriers vs TT; p=0.005). It also predicted persistent hyperglycaemia in a nested case-control study involving 158 sex- and age-matched controls with persistent NGT (p=0.012, adjusted for BMI), and that of diabetes or glycaemia progression (p<0.05) in a meta-analysis that also included two published studies in Europid subjects. Conclusions/interpretation: Our findings support a significant role of this common ADIPOQ gene polymorphism in predicting glycaemic status in southern Chinese people. © Springer-Verlag 2006.en_HK
dc.languageengen_HK
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00125/index.htmen_HK
dc.relation.ispartofDiabetologiaen_HK
dc.subjectAdiponectinen_HK
dc.subjectDiabetesen_HK
dc.subjectGeneen_HK
dc.subjectHyperglycaemiaen_HK
dc.subjectIGTen_HK
dc.subjectImpaired glucose toleranceen_HK
dc.subjectSingle-nucleotide polymorphismen_HK
dc.subject.meshAdiponectin - genetics-
dc.subject.meshGlucose Intolerance - blood - genetics-
dc.subject.meshLinkage Disequilibrium-
dc.subject.meshPolymorphism, Genetic-
dc.subject.meshAdult-
dc.titlePolymorphisms of the gene encoding adiponectin and glycaemic outcome of Chinese subjects with impaired glucose tolerance: A 5-year follow-up studyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0012-186X&volume=49&spage=1806&epage=15&date=2006&atitle=Polymorphisms+of+the+gene+encoding+adiponectin+and+glycaemic+outcome+of+Chinese+subjects+with+impaired+glucose+tolerance:+a+5-year+follow-up+studyen_HK
dc.identifier.emailTso, AWK: awk.tso@gmail.comen_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.emailXu, A: amxu@hkucc.hku.hken_HK
dc.identifier.emailCheung, BMY: mycheung@hku.hken_HK
dc.identifier.emailCheng, KKY: dorncky@hkucc.hku.hken_HK
dc.identifier.emailLam, KSL: ksllam@hku.hken_HK
dc.identifier.authorityTso, AWK=rp00535en_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.identifier.authorityXu, A=rp00485en_HK
dc.identifier.authorityCheung, BMY=rp01321en_HK
dc.identifier.authorityCheng, KKY=rp01672en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00125-006-0324-2en_HK
dc.identifier.pmid16788799-
dc.identifier.scopuseid_2-s2.0-33745801304en_HK
dc.identifier.hkuros126091en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33745801304&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume49en_HK
dc.identifier.issue8en_HK
dc.identifier.spage1806en_HK
dc.identifier.epage1815en_HK
dc.identifier.isiWOS:000238859900013-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridTso, AWK=6701371436en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.scopusauthoridWat, NMS=6602131754en_HK
dc.identifier.scopusauthoridXu, A=7202655409en_HK
dc.identifier.scopusauthoridCheung, BMY=7103294806en_HK
dc.identifier.scopusauthoridRong, R=7003938735en_HK
dc.identifier.scopusauthoridFong, CHY=14033917100en_HK
dc.identifier.scopusauthoridXu, JY=8947805200en_HK
dc.identifier.scopusauthoridCheng, KKY=7402997599en_HK
dc.identifier.scopusauthoridJanus, ED=7006936536en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK

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