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- Publisher Website: 10.1097/00007890-200101150-00010
- Scopus: eid_2-s2.0-0035863249
- PMID: 11211196
- WOS: WOS:000166637500010
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Article: Nosocomial outbreak of parvovirus B19 infection in a renal transplant unit
Title | Nosocomial outbreak of parvovirus B19 infection in a renal transplant unit |
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Authors | |
Issue Date | 2001 |
Publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.transplantjournal.com |
Citation | Transplantation, 2001, v. 71 n. 1, p. 59-64 How to Cite? |
Abstract | Background. Parvovirus B19 (B19) infection is known to cause chronic infection leading to anemia in immunocompromised patients. Although nosocomial B19 infections in immunocompetent patients have been documented, no outbreaks in immunocompromised patients have been previously reported. Whether transmission can occur from a patient with chronic infection is also unknown. Methods. An outbreak of B19 infection in a renal transplant unit was investigated by molecular analysis of the virus strains and a case-control study. Results. Three patients had genetically identical virus strains suggesting the occurrence of nosocomial transmission. The index case transmitted infection many weeks after the onset of her clinical symptoms. Other patients at risk of acquiring infection were those most intensively immunosuppressed. Viral load in the serum correlated with the hematological response. A rebound in the viral load was associated with clinical relapse and the failure of i.v. immunoglobulin therapy. Conclusion. Nosocomial transmission of B19 can occur from immunocompromised patients even when they are in the chronic stage of the infection. The clinical and virological response to i.v. immunoglobulin therapy is variable and depends on the overall level of immunosuppression of the patient. |
Persistent Identifier | http://hdl.handle.net/10722/77130 |
ISSN | 2023 Impact Factor: 5.3 2023 SCImago Journal Rankings: 1.371 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Lui, SL | en_HK |
dc.contributor.author | Luk, WK | en_HK |
dc.contributor.author | Cheung, CY | en_HK |
dc.contributor.author | Chan, TM | en_HK |
dc.contributor.author | Lai, KN | en_HK |
dc.contributor.author | Peiris, JSM | en_HK |
dc.date.accessioned | 2010-09-06T07:28:35Z | - |
dc.date.available | 2010-09-06T07:28:35Z | - |
dc.date.issued | 2001 | en_HK |
dc.identifier.citation | Transplantation, 2001, v. 71 n. 1, p. 59-64 | en_HK |
dc.identifier.issn | 0041-1337 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/77130 | - |
dc.description.abstract | Background. Parvovirus B19 (B19) infection is known to cause chronic infection leading to anemia in immunocompromised patients. Although nosocomial B19 infections in immunocompetent patients have been documented, no outbreaks in immunocompromised patients have been previously reported. Whether transmission can occur from a patient with chronic infection is also unknown. Methods. An outbreak of B19 infection in a renal transplant unit was investigated by molecular analysis of the virus strains and a case-control study. Results. Three patients had genetically identical virus strains suggesting the occurrence of nosocomial transmission. The index case transmitted infection many weeks after the onset of her clinical symptoms. Other patients at risk of acquiring infection were those most intensively immunosuppressed. Viral load in the serum correlated with the hematological response. A rebound in the viral load was associated with clinical relapse and the failure of i.v. immunoglobulin therapy. Conclusion. Nosocomial transmission of B19 can occur from immunocompromised patients even when they are in the chronic stage of the infection. The clinical and virological response to i.v. immunoglobulin therapy is variable and depends on the overall level of immunosuppression of the patient. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.transplantjournal.com | en_HK |
dc.relation.ispartof | Transplantation | en_HK |
dc.rights | Transplantation. Copyright © Lippincott Williams & Wilkins. | en_HK |
dc.subject.mesh | Adult | en_HK |
dc.subject.mesh | Case-Control Studies | en_HK |
dc.subject.mesh | Cross Infection - transmission | en_HK |
dc.subject.mesh | DNA, Viral - blood | en_HK |
dc.subject.mesh | Disease Outbreaks | en_HK |
dc.subject.mesh | Female | en_HK |
dc.subject.mesh | Hospital Units - organization & administration | en_HK |
dc.subject.mesh | Humans | en_HK |
dc.subject.mesh | Kidney Transplantation | en_HK |
dc.subject.mesh | Middle Aged | en_HK |
dc.subject.mesh | Parvoviridae Infections - transmission | en_HK |
dc.subject.mesh | Parvovirus B19, Human | en_HK |
dc.title | Nosocomial outbreak of parvovirus B19 infection in a renal transplant unit | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0041-1337&volume=71&spage=59&epage=64&date=2001&atitle=Nosocomial+outbreak+of+parvovirus+B19+infection+in+a+renal+transplant+unit | en_HK |
dc.identifier.email | Cheung, CY: chungey@hkucc.hku.hk | en_HK |
dc.identifier.email | Chan, TM: dtmchan@hku.hk | en_HK |
dc.identifier.email | Lai, KN: knlai@hku.hk | en_HK |
dc.identifier.email | Peiris, JSM: malik@hkucc.hku.hk | en_HK |
dc.identifier.authority | Cheung, CY=rp00404 | en_HK |
dc.identifier.authority | Chan, TM=rp00394 | en_HK |
dc.identifier.authority | Lai, KN=rp00324 | en_HK |
dc.identifier.authority | Peiris, JSM=rp00410 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1097/00007890-200101150-00010 | - |
dc.identifier.pmid | 11211196 | - |
dc.identifier.scopus | eid_2-s2.0-0035863249 | en_HK |
dc.identifier.hkuros | 60529 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0035863249&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 71 | en_HK |
dc.identifier.issue | 1 | en_HK |
dc.identifier.spage | 59 | en_HK |
dc.identifier.epage | 64 | en_HK |
dc.identifier.isi | WOS:000166637500010 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Lui, SL=7102379130 | en_HK |
dc.identifier.scopusauthorid | Luk, WK=7005237832 | en_HK |
dc.identifier.scopusauthorid | Cheung, CY=7202061836 | en_HK |
dc.identifier.scopusauthorid | Chan, TM=7402687700 | en_HK |
dc.identifier.scopusauthorid | Lai, KN=7402135706 | en_HK |
dc.identifier.scopusauthorid | Peiris, JSM=7005486823 | en_HK |
dc.identifier.issnl | 0041-1337 | - |