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Article: p21 gene polymorphisms in systemic lupus erythematosus

Titlep21 gene polymorphisms in systemic lupus erythematosus
Authors
KeywordsHaplotype
p21
Single nucleotide polymorphism
SLE
Susceptibility
Issue Date2007
PublisherOxford University Press. The Journal's web site is located at http://rheumatology.oxfordjournals.org/
Citation
Rheumatology, 2007, v. 46 n. 2, p. 220-226 How to Cite?
AbstractObjective. Cyclin-dependent kinase inhibitor 1A (p21) is a negative regulator in the cell cycle. Development of sex-linked lupus-like syndrome in p21 -/- mice and reduced p21 gene expression in patients with systemic lupus erythematosus (SLE) compared with those in healthy controls suggested that p21 is a susceptibility gene of SLE. We investigated the same by a case-control association study. Methods. Six single nucleotide polymorphisms, p21US G/A, p21DS C/A, p21-1022 G/A, p21C31 C/A, p21In2 G/C and p21UTR T/C, were genotyped in 516 SLE patients and 693 healthy controls. Association of genotypes and alleles with disease, disease phenotypes, haplotypes construction, linkage disequilibrium analysis and p21 mRNA expression were performed. Results. We found a significant association of p21US A allele (OR = 0.23, 95% CI: 0.14-0.38, P < 0.001) and p21-1022 A allele (OR = 1.95, 95% CI: 1.37-2.78, P < 0.001) with SLE. We identified significant differences in the frequencies of haplotypes ht1-A CACCC, which contains p21US A allele, and ht2-GC A CCC, which contains p21-1022 A allele, between SLE patients and controls (P < 0.0001). Besides, the p21US GA was associated with SLE patients suffering from arthritis (P = 0.003). We also observed differential p21 mRNA expressions among different genotypes of p21US and p21-1022 which were statistically significant. Conclusion. Our results suggested that the p21US A allele and p21-1022 A allele were both associated with the development of SLE, and the p21US A allele was associated with arthritis in SLE patients. © 2007 Oxford University Press.
Persistent Identifierhttp://hdl.handle.net/10722/77103
ISSN
2015 Impact Factor: 4.524
2015 SCImago Journal Rankings: 1.449
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKong, EKPen_HK
dc.contributor.authorChong, WPen_HK
dc.contributor.authorWong, WHSen_HK
dc.contributor.authorLau, CSen_HK
dc.contributor.authorChan, TMen_HK
dc.contributor.authorNg, PKMen_HK
dc.contributor.authorSong, YQen_HK
dc.contributor.authorMak, Wen_HK
dc.contributor.authorLau, YLen_HK
dc.date.accessioned2010-09-06T07:28:18Z-
dc.date.available2010-09-06T07:28:18Z-
dc.date.issued2007en_HK
dc.identifier.citationRheumatology, 2007, v. 46 n. 2, p. 220-226en_HK
dc.identifier.issn1462-0324en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77103-
dc.description.abstractObjective. Cyclin-dependent kinase inhibitor 1A (p21) is a negative regulator in the cell cycle. Development of sex-linked lupus-like syndrome in p21 -/- mice and reduced p21 gene expression in patients with systemic lupus erythematosus (SLE) compared with those in healthy controls suggested that p21 is a susceptibility gene of SLE. We investigated the same by a case-control association study. Methods. Six single nucleotide polymorphisms, p21US G/A, p21DS C/A, p21-1022 G/A, p21C31 C/A, p21In2 G/C and p21UTR T/C, were genotyped in 516 SLE patients and 693 healthy controls. Association of genotypes and alleles with disease, disease phenotypes, haplotypes construction, linkage disequilibrium analysis and p21 mRNA expression were performed. Results. We found a significant association of p21US A allele (OR = 0.23, 95% CI: 0.14-0.38, P < 0.001) and p21-1022 A allele (OR = 1.95, 95% CI: 1.37-2.78, P < 0.001) with SLE. We identified significant differences in the frequencies of haplotypes ht1-A CACCC, which contains p21US A allele, and ht2-GC A CCC, which contains p21-1022 A allele, between SLE patients and controls (P < 0.0001). Besides, the p21US GA was associated with SLE patients suffering from arthritis (P = 0.003). We also observed differential p21 mRNA expressions among different genotypes of p21US and p21-1022 which were statistically significant. Conclusion. Our results suggested that the p21US A allele and p21-1022 A allele were both associated with the development of SLE, and the p21US A allele was associated with arthritis in SLE patients. © 2007 Oxford University Press.en_HK
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://rheumatology.oxfordjournals.org/en_HK
dc.relation.ispartofRheumatologyen_HK
dc.rightsRheumatology. Copyright © Oxford University Press.en_HK
dc.subjectHaplotypeen_HK
dc.subjectp21en_HK
dc.subjectSingle nucleotide polymorphismen_HK
dc.subjectSLEen_HK
dc.subjectSusceptibilityen_HK
dc.subject.meshCyclin-Dependent Kinase Inhibitor p21 - biosynthesis - genetics-
dc.subject.meshLupus Erythematosus, Systemic - blood - genetics-
dc.subject.meshPolymorphism, Single Nucleotide-
dc.subject.meshAdult-
dc.subject.meshCase-Control Studies-
dc.titlep21 gene polymorphisms in systemic lupus erythematosusen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1462-0324&volume=46&issue=2&spage=220&epage=226&date=2007&atitle=p21+Gene+Polymorphisms+in+Systemic+Lupus+Erythematosusen_HK
dc.identifier.emailLau, CS:cslau@hku.hken_HK
dc.identifier.emailChan, TM:dtmchan@hku.hken_HK
dc.identifier.emailSong, YQ:songy@hkucc.hku.hken_HK
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_HK
dc.identifier.authorityLau, CS=rp01348en_HK
dc.identifier.authorityChan, TM=rp00394en_HK
dc.identifier.authoritySong, YQ=rp00488en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1093/rheumatology/kel210en_HK
dc.identifier.pmid16837471-
dc.identifier.scopuseid_2-s2.0-33846683738en_HK
dc.identifier.hkuros134793en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33846683738&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume46en_HK
dc.identifier.issue2en_HK
dc.identifier.spage220en_HK
dc.identifier.epage226en_HK
dc.identifier.isiWOS:000243810100008-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridKong, EKP=8617703100en_HK
dc.identifier.scopusauthoridChong, WP=8634104400en_HK
dc.identifier.scopusauthoridWong, WHS=35789454600en_HK
dc.identifier.scopusauthoridLau, CS=14035682100en_HK
dc.identifier.scopusauthoridChan, TM=7402687700en_HK
dc.identifier.scopusauthoridNg, PKM=13204578800en_HK
dc.identifier.scopusauthoridSong, YQ=7404921212en_HK
dc.identifier.scopusauthoridMak, W=22934897600en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK
dc.identifier.citeulike1070893-

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