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Article: Idiopathic severe recurrent transverse myelitis: A restricted variant of neuromyelitis optica

TitleIdiopathic severe recurrent transverse myelitis: A restricted variant of neuromyelitis optica
Authors
KeywordsBrainstem
Idiopathic transverse myelitis
Multiple sclerosis
Neuromyelitis optica
Spinal cord
Issue Date2005
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/clineuro
Citation
Clinical Neurology And Neurosurgery, 2005, v. 107 n. 2, p. 132-135 How to Cite?
AbstractRecurrent idiopathic transverse myelitis occur in multiple sclerosis (MS) and neuromyelitis optica (NMO). In NMO, acute optic neuritis and myelitis occur, either monophasic or relapsing, without clinical manifestations of involvement of other parts of the central nervous system (CNS). Recent evidence suggests that NMO is different from multiple sclerosis. The authors reported two patients having severe recurrent transverse myelitis sparing the optic nerves and cerebral hemispheres. Both patients had longitudinally extensive myelitis in some attacks with poor neurological outcome despite aggressive immunomodulatory therapy. One patient had prominent clinical features of brainstem injury with radiological and histological confirmation of brainstem involvement, and the other patient had trigeminal neuralgia suggestive of possible brainstem dysfunction. Histologically, prominent necrosis and neutrophilic infiltration of spinal cord tissue without eosinophils or hyalinized vessels were observed, and oligoclonal bands were absent in their cerebrospinal fluid. It is likely to be a distinct idiopathic inflammatory demyelinating disorder restricted to the spinal cord and brainstem different from MS, but within the spectrum of NMO with probably an autoimmune basis. © 2004 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/77070
ISSN
2015 Impact Factor: 1.198
2015 SCImago Journal Rankings: 0.555
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, KHen_HK
dc.contributor.authorTsang, KLen_HK
dc.contributor.authorFong, GCYen_HK
dc.contributor.authorCheung, RTFen_HK
dc.contributor.authorHo, SLen_HK
dc.date.accessioned2010-09-06T07:27:56Z-
dc.date.available2010-09-06T07:27:56Z-
dc.date.issued2005en_HK
dc.identifier.citationClinical Neurology And Neurosurgery, 2005, v. 107 n. 2, p. 132-135en_HK
dc.identifier.issn0303-8467en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77070-
dc.description.abstractRecurrent idiopathic transverse myelitis occur in multiple sclerosis (MS) and neuromyelitis optica (NMO). In NMO, acute optic neuritis and myelitis occur, either monophasic or relapsing, without clinical manifestations of involvement of other parts of the central nervous system (CNS). Recent evidence suggests that NMO is different from multiple sclerosis. The authors reported two patients having severe recurrent transverse myelitis sparing the optic nerves and cerebral hemispheres. Both patients had longitudinally extensive myelitis in some attacks with poor neurological outcome despite aggressive immunomodulatory therapy. One patient had prominent clinical features of brainstem injury with radiological and histological confirmation of brainstem involvement, and the other patient had trigeminal neuralgia suggestive of possible brainstem dysfunction. Histologically, prominent necrosis and neutrophilic infiltration of spinal cord tissue without eosinophils or hyalinized vessels were observed, and oligoclonal bands were absent in their cerebrospinal fluid. It is likely to be a distinct idiopathic inflammatory demyelinating disorder restricted to the spinal cord and brainstem different from MS, but within the spectrum of NMO with probably an autoimmune basis. © 2004 Elsevier B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/clineuroen_HK
dc.relation.ispartofClinical Neurology and Neurosurgeryen_HK
dc.subjectBrainstemen_HK
dc.subjectIdiopathic transverse myelitisen_HK
dc.subjectMultiple sclerosisen_HK
dc.subjectNeuromyelitis opticaen_HK
dc.subjectSpinal corden_HK
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshMyelitis, Transverse - diagnosis - etiology - therapy-
dc.subject.meshRecurrence-
dc.subject.meshSeverity of Illness Index-
dc.titleIdiopathic severe recurrent transverse myelitis: A restricted variant of neuromyelitis opticaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0303-8467&volume=107&issue=2&spage=132&epage=135&date=2005&atitle=Idiopathic+severe+recurrent+transverse+myelitis:+a+restricted+variant+of+neuromyelitis+opticaen_HK
dc.identifier.emailCheung, RTF:rtcheung@hku.hken_HK
dc.identifier.emailHo, SL:slho@hku.hken_HK
dc.identifier.authorityCheung, RTF=rp00434en_HK
dc.identifier.authorityHo, SL=rp00240en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.clineuro.2004.05.001en_HK
dc.identifier.pmid15708229-
dc.identifier.scopuseid_2-s2.0-13644259070en_HK
dc.identifier.hkuros168588en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-13644259070&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume107en_HK
dc.identifier.issue2en_HK
dc.identifier.spage132en_HK
dc.identifier.epage135en_HK
dc.identifier.isiWOS:000227317800011-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridChan, KH=7406034963en_HK
dc.identifier.scopusauthoridTsang, KL=7201554745en_HK
dc.identifier.scopusauthoridFong, GCY=36726526600en_HK
dc.identifier.scopusauthoridCheung, RTF=7202397498en_HK
dc.identifier.scopusauthoridHo, SL=25959633500en_HK

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