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Article: Incidence and outcome of antiglomerular basement membrane disease in Chinese
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TitleIncidence and outcome of antiglomerular basement membrane disease in Chinese
 
AuthorsLi, FK
Tse, KC
Lam, MF
Yip, TPS
Lui, SL
Chan, GSW1
Chan, KW1
Chan, EYT1
Choy, BY
Lo, WK
Chan, TM
Lai, KN1
 
KeywordsAntiglomerular basement membrane antibody disease
Crescentic glomerulonephritis
Goodpasture's syndrome
 
Issue Date2004
 
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/NEP
 
CitationNephrology, 2004, v. 9 n. 2, p. 100-104 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1440-1797.2003.00234.x
 
AbstractBackground: Antiglomerular basement membrane (anti-GBM) disease is an uncommon disease, especially among Asian population. Many reports and studies on this condition in the Caucasian population are available, but little information exists on anti-GBM disease in Asians. To study the incidence and clinical characteristics of anti-GBM disease among Chinese patients, we reviewed our experience of anti-GBM disease in our hospital (Queen Mary Hospital, Hong Kong) from 1992 to 2003. Methods: All patients who were admitted for acute renal impairment, which was caused by crescentic glomerulonephritis associated with linear immunoglobulin G (IgG) staining on immunofluorescence, were included in the analysis. Serum anti-GBM antibodies were detected by either enzyme-linked immunofluorescence or indirect immunofluorescence. Ten patients were treated for anti-GBM disease during this 11-year period, yielding an incidence of approximately 0.6 cases per million population per year. Results: In this cohort, anti-GBM disease predominantly affected older patients (mean age: 58.6 ± 21.7 years). Eight patients were aged between 60 and 80 years and there was a female preponderance (M:F = 2:8). The 1-year renal and patient survival was 15% (95% Cl 0-40%) and 70% (95% Cl 42-98%), respectively. Most patients presented with non-specific symptoms as well as impaired renal function. Detection of anti-GBM antibody provided a good screening test for the disease. Antiglomerular basement membrane antibodies were not detected in two patients. All but two patients received steroid, cyclophosphamide and intensive plasmapheresis therapy. Haemoptysis occurred in four patients (40%), and usually lagged behind the renal presentation and commencement of treatment. Six patients required long-term dialysis after the acute disease. Three patients died from the disease, two died from pulmonary complications and one died suddenly after a partial recovery of renal function. Conclusion: Antiglomerular basement membrane disease is uncommon among the Chinese population. It predominantly affects older patients, and prognosis is poor. Long-term preservation of renal function after the initial attack is unusual.
 
ISSN1320-5358
2013 Impact Factor: 1.864
 
DOIhttp://dx.doi.org/10.1111/j.1440-1797.2003.00234.x
 
ISI Accession Number IDWOS:000220522100011
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLi, FK
 
dc.contributor.authorTse, KC
 
dc.contributor.authorLam, MF
 
dc.contributor.authorYip, TPS
 
dc.contributor.authorLui, SL
 
dc.contributor.authorChan, GSW
 
dc.contributor.authorChan, KW
 
dc.contributor.authorChan, EYT
 
dc.contributor.authorChoy, BY
 
dc.contributor.authorLo, WK
 
dc.contributor.authorChan, TM
 
dc.contributor.authorLai, KN
 
dc.date.accessioned2010-09-06T07:26:31Z
 
dc.date.available2010-09-06T07:26:31Z
 
dc.date.issued2004
 
dc.description.abstractBackground: Antiglomerular basement membrane (anti-GBM) disease is an uncommon disease, especially among Asian population. Many reports and studies on this condition in the Caucasian population are available, but little information exists on anti-GBM disease in Asians. To study the incidence and clinical characteristics of anti-GBM disease among Chinese patients, we reviewed our experience of anti-GBM disease in our hospital (Queen Mary Hospital, Hong Kong) from 1992 to 2003. Methods: All patients who were admitted for acute renal impairment, which was caused by crescentic glomerulonephritis associated with linear immunoglobulin G (IgG) staining on immunofluorescence, were included in the analysis. Serum anti-GBM antibodies were detected by either enzyme-linked immunofluorescence or indirect immunofluorescence. Ten patients were treated for anti-GBM disease during this 11-year period, yielding an incidence of approximately 0.6 cases per million population per year. Results: In this cohort, anti-GBM disease predominantly affected older patients (mean age: 58.6 ± 21.7 years). Eight patients were aged between 60 and 80 years and there was a female preponderance (M:F = 2:8). The 1-year renal and patient survival was 15% (95% Cl 0-40%) and 70% (95% Cl 42-98%), respectively. Most patients presented with non-specific symptoms as well as impaired renal function. Detection of anti-GBM antibody provided a good screening test for the disease. Antiglomerular basement membrane antibodies were not detected in two patients. All but two patients received steroid, cyclophosphamide and intensive plasmapheresis therapy. Haemoptysis occurred in four patients (40%), and usually lagged behind the renal presentation and commencement of treatment. Six patients required long-term dialysis after the acute disease. Three patients died from the disease, two died from pulmonary complications and one died suddenly after a partial recovery of renal function. Conclusion: Antiglomerular basement membrane disease is uncommon among the Chinese population. It predominantly affects older patients, and prognosis is poor. Long-term preservation of renal function after the initial attack is unusual.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationNephrology, 2004, v. 9 n. 2, p. 100-104 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1440-1797.2003.00234.x
 
dc.identifier.doihttp://dx.doi.org/10.1111/j.1440-1797.2003.00234.x
 
dc.identifier.epage104
 
dc.identifier.hkuros86753
 
dc.identifier.isiWOS:000220522100011
 
dc.identifier.issn1320-5358
2013 Impact Factor: 1.864
 
dc.identifier.issue2
 
dc.identifier.openurl
 
dc.identifier.pmid15056270
 
dc.identifier.scopuseid_2-s2.0-11144354174
 
dc.identifier.spage100
 
dc.identifier.urihttp://hdl.handle.net/10722/76937
 
dc.identifier.volume9
 
dc.languageeng
 
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/NEP
 
dc.publisher.placeAustralia
 
dc.relation.ispartofNephrology
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdolescent
 
dc.subject.meshAdult
 
dc.subject.meshAged
 
dc.subject.meshAnti-Glomerular Basement Membrane Disease - complications - epidemiology - ethnology
 
dc.subject.meshAntibodies - blood
 
dc.subject.meshAsian Continental Ancestry Group
 
dc.subject.meshAutoantibodies
 
dc.subject.meshFemale
 
dc.subject.meshHumans
 
dc.subject.meshIncidence
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshPrognosis
 
dc.subjectAntiglomerular basement membrane antibody disease
 
dc.subjectCrescentic glomerulonephritis
 
dc.subjectGoodpasture's syndrome
 
dc.titleIncidence and outcome of antiglomerular basement membrane disease in Chinese
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong