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Article: [13C]-Urea breath test without prior fasting and without test meal is accurate for the detection of Helicobacter pylori infection in Chinese

Title[13C]-Urea breath test without prior fasting and without test meal is accurate for the detection of Helicobacter pylori infection in Chinese
Authors
Keywords[13C]-urea breath test
Chinese
Helicobacter pylori
Non-fasting
Test meal
Issue Date2002
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGH
Citation
Journal Of Gastroenterology And Hepatology, 2002, v. 17 n. 8, p. 834-838 How to Cite?
AbstractBackground and Aim: Conventional [13C]-urea breath test ([13C]-UBT) requires prior fasting and a test meal, which theoretically improves the accuracy of the test. However, recent studies have suggested that prior fasting and test meal may not be essential. We aimed to determine the accuracy of a new [13C]-UBT protocol without fasting in Chinese. Methods: Dyspeptic patients referred for upper endoscopy were recruited. The gold standard for Helicobacter pylori infection was the combination of Campylobacter-like organism (CLO) test and histology. Group I (n = 213) patients underwent [13C]-UBT with prior fasting and with citrate acid test meal. Group II (n = 123) patients underwent [13C]-UBT without prior fasting but with test meal. Group III (n = 90) patients underwent [13C]-UBT without prior fasting and without test meal. Results: The highest accuracy for groups I, II and III was 96.7, 95.1 and 95.5% using a cut-off value of 5.0, 5.5 and 3.5, respectively. The sensitivities and specificities were 97.4 and 95.8% in group I, 93.3 and 96.8% in group II, and 96.5 and 93.9% in group III, respectively. Conclusion: The [13C]-UBT protocols without prior fasting and either with or without test meal produce highly accurate and reliable results in the Chinese population. © 2002 Blackwell Publishing Asia Pty Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/76930
ISSN
2014 Impact Factor: 3.504
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNg, FHen_HK
dc.contributor.authorLai, KCen_HK
dc.contributor.authorWong, BCYen_HK
dc.contributor.authorWong, WMen_HK
dc.contributor.authorWong, SYen_HK
dc.contributor.authorChow, KCen_HK
dc.contributor.authorYuen, STen_HK
dc.contributor.authorLeung, SYen_HK
dc.contributor.authorLam, SKen_HK
dc.date.accessioned2010-09-06T07:26:27Z-
dc.date.available2010-09-06T07:26:27Z-
dc.date.issued2002en_HK
dc.identifier.citationJournal Of Gastroenterology And Hepatology, 2002, v. 17 n. 8, p. 834-838en_HK
dc.identifier.issn0815-9319en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76930-
dc.description.abstractBackground and Aim: Conventional [13C]-urea breath test ([13C]-UBT) requires prior fasting and a test meal, which theoretically improves the accuracy of the test. However, recent studies have suggested that prior fasting and test meal may not be essential. We aimed to determine the accuracy of a new [13C]-UBT protocol without fasting in Chinese. Methods: Dyspeptic patients referred for upper endoscopy were recruited. The gold standard for Helicobacter pylori infection was the combination of Campylobacter-like organism (CLO) test and histology. Group I (n = 213) patients underwent [13C]-UBT with prior fasting and with citrate acid test meal. Group II (n = 123) patients underwent [13C]-UBT without prior fasting but with test meal. Group III (n = 90) patients underwent [13C]-UBT without prior fasting and without test meal. Results: The highest accuracy for groups I, II and III was 96.7, 95.1 and 95.5% using a cut-off value of 5.0, 5.5 and 3.5, respectively. The sensitivities and specificities were 97.4 and 95.8% in group I, 93.3 and 96.8% in group II, and 96.5 and 93.9% in group III, respectively. Conclusion: The [13C]-UBT protocols without prior fasting and either with or without test meal produce highly accurate and reliable results in the Chinese population. © 2002 Blackwell Publishing Asia Pty Ltd.en_HK
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGHen_HK
dc.relation.ispartofJournal of Gastroenterology and Hepatologyen_HK
dc.subject[13C]-urea breath testen_HK
dc.subjectChineseen_HK
dc.subjectHelicobacter pylorien_HK
dc.subjectNon-fastingen_HK
dc.subjectTest mealen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshBreath Testsen_HK
dc.subject.meshCarbon Isotopes - analysis - diagnostic useen_HK
dc.subject.meshChinaen_HK
dc.subject.meshEatingen_HK
dc.subject.meshFastingen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHelicobacter Infections - diagnosisen_HK
dc.subject.meshHelicobacter pylori - isolation & purificationen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshReproducibility of Resultsen_HK
dc.subject.meshSensitivity and Specificityen_HK
dc.subject.meshUrea - analysis - diagnostic useen_HK
dc.title[13C]-Urea breath test without prior fasting and without test meal is accurate for the detection of Helicobacter pylori infection in Chineseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0815-9319&volume=17&issue=8&spage=834&epage=838&date=2002&atitle=[13C]-Urea+breath+test+without+prior+fasting+and+without+test+meal+is+accurate+for+the+detection+of+Helicobacter+pylori+infection+in+Chineseen_HK
dc.identifier.emailWong, BCY:bcywong@hku.hken_HK
dc.identifier.emailLeung, SY:suetyi@hkucc.hku.hken_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.identifier.authorityLeung, SY=rp00359en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1046/j.1440-1746.2002.02833.xen_HK
dc.identifier.pmid12164957en_HK
dc.identifier.scopuseid_2-s2.0-0036025161en_HK
dc.identifier.hkuros81947en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036025161&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume17en_HK
dc.identifier.issue8en_HK
dc.identifier.spage834en_HK
dc.identifier.epage838en_HK
dc.identifier.isiWOS:000177282100005-
dc.publisher.placeAustraliaen_HK
dc.identifier.scopusauthoridNg, FH=16936078000en_HK
dc.identifier.scopusauthoridLai, KC=7402135595en_HK
dc.identifier.scopusauthoridWong, BCY=7402023340en_HK
dc.identifier.scopusauthoridWong, WM=7403972413en_HK
dc.identifier.scopusauthoridWong, SY=7404590845en_HK
dc.identifier.scopusauthoridChow, KC=7202180726en_HK
dc.identifier.scopusauthoridYuen, ST=8323342200en_HK
dc.identifier.scopusauthoridLeung, SY=7202044886en_HK
dc.identifier.scopusauthoridLam, SK=7402279473en_HK

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