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Article: [13C]-Urea breath test without prior fasting and without test meal is accurate for the detection of Helicobacter pylori infection in Chinese
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Title[13C]-Urea breath test without prior fasting and without test meal is accurate for the detection of Helicobacter pylori infection in Chinese
 
AuthorsNg, FH2
Lai, KC
Wong, BCY1
Wong, WM
Wong, SY2
Chow, KC2
Yuen, ST1
Leung, SY1
Lam, SK
 
Keywords[13C]-urea breath test
Chinese
Helicobacter pylori
Non-fasting
Test meal
 
Issue Date2002
 
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGH
 
CitationJournal Of Gastroenterology And Hepatology, 2002, v. 17 n. 8, p. 834-838 [How to Cite?]
DOI: http://dx.doi.org/10.1046/j.1440-1746.2002.02833.x
 
AbstractBackground and Aim: Conventional [13C]-urea breath test ([13C]-UBT) requires prior fasting and a test meal, which theoretically improves the accuracy of the test. However, recent studies have suggested that prior fasting and test meal may not be essential. We aimed to determine the accuracy of a new [13C]-UBT protocol without fasting in Chinese. Methods: Dyspeptic patients referred for upper endoscopy were recruited. The gold standard for Helicobacter pylori infection was the combination of Campylobacter-like organism (CLO) test and histology. Group I (n = 213) patients underwent [13C]-UBT with prior fasting and with citrate acid test meal. Group II (n = 123) patients underwent [13C]-UBT without prior fasting but with test meal. Group III (n = 90) patients underwent [13C]-UBT without prior fasting and without test meal. Results: The highest accuracy for groups I, II and III was 96.7, 95.1 and 95.5% using a cut-off value of 5.0, 5.5 and 3.5, respectively. The sensitivities and specificities were 97.4 and 95.8% in group I, 93.3 and 96.8% in group II, and 96.5 and 93.9% in group III, respectively. Conclusion: The [13C]-UBT protocols without prior fasting and either with or without test meal produce highly accurate and reliable results in the Chinese population. © 2002 Blackwell Publishing Asia Pty Ltd.
 
ISSN0815-9319
2012 Impact Factor: 3.325
2012 SCImago Journal Rankings: 0.985
 
DOIhttp://dx.doi.org/10.1046/j.1440-1746.2002.02833.x
 
ISI Accession Number IDWOS:000177282100005
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorNg, FH
 
dc.contributor.authorLai, KC
 
dc.contributor.authorWong, BCY
 
dc.contributor.authorWong, WM
 
dc.contributor.authorWong, SY
 
dc.contributor.authorChow, KC
 
dc.contributor.authorYuen, ST
 
dc.contributor.authorLeung, SY
 
dc.contributor.authorLam, SK
 
dc.date.accessioned2010-09-06T07:26:27Z
 
dc.date.available2010-09-06T07:26:27Z
 
dc.date.issued2002
 
dc.description.abstractBackground and Aim: Conventional [13C]-urea breath test ([13C]-UBT) requires prior fasting and a test meal, which theoretically improves the accuracy of the test. However, recent studies have suggested that prior fasting and test meal may not be essential. We aimed to determine the accuracy of a new [13C]-UBT protocol without fasting in Chinese. Methods: Dyspeptic patients referred for upper endoscopy were recruited. The gold standard for Helicobacter pylori infection was the combination of Campylobacter-like organism (CLO) test and histology. Group I (n = 213) patients underwent [13C]-UBT with prior fasting and with citrate acid test meal. Group II (n = 123) patients underwent [13C]-UBT without prior fasting but with test meal. Group III (n = 90) patients underwent [13C]-UBT without prior fasting and without test meal. Results: The highest accuracy for groups I, II and III was 96.7, 95.1 and 95.5% using a cut-off value of 5.0, 5.5 and 3.5, respectively. The sensitivities and specificities were 97.4 and 95.8% in group I, 93.3 and 96.8% in group II, and 96.5 and 93.9% in group III, respectively. Conclusion: The [13C]-UBT protocols without prior fasting and either with or without test meal produce highly accurate and reliable results in the Chinese population. © 2002 Blackwell Publishing Asia Pty Ltd.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Gastroenterology And Hepatology, 2002, v. 17 n. 8, p. 834-838 [How to Cite?]
DOI: http://dx.doi.org/10.1046/j.1440-1746.2002.02833.x
 
dc.identifier.doihttp://dx.doi.org/10.1046/j.1440-1746.2002.02833.x
 
dc.identifier.epage838
 
dc.identifier.hkuros81947
 
dc.identifier.isiWOS:000177282100005
 
dc.identifier.issn0815-9319
2012 Impact Factor: 3.325
2012 SCImago Journal Rankings: 0.985
 
dc.identifier.issue8
 
dc.identifier.openurl
 
dc.identifier.pmid12164957
 
dc.identifier.scopuseid_2-s2.0-0036025161
 
dc.identifier.spage834
 
dc.identifier.urihttp://hdl.handle.net/10722/76930
 
dc.identifier.volume17
 
dc.languageeng
 
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGH
 
dc.publisher.placeAustralia
 
dc.relation.ispartofJournal of Gastroenterology and Hepatology
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdult
 
dc.subject.meshAged
 
dc.subject.meshBreath Tests
 
dc.subject.meshCarbon Isotopes - analysis - diagnostic use
 
dc.subject.meshChina
 
dc.subject.meshEating
 
dc.subject.meshFasting
 
dc.subject.meshFemale
 
dc.subject.meshHelicobacter Infections - diagnosis
 
dc.subject.meshHelicobacter pylori - isolation & purification
 
dc.subject.meshHumans
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshReproducibility of Results
 
dc.subject.meshSensitivity and Specificity
 
dc.subject.meshUrea - analysis - diagnostic use
 
dc.subject[13C]-urea breath test
 
dc.subjectChinese
 
dc.subjectHelicobacter pylori
 
dc.subjectNon-fasting
 
dc.subjectTest meal
 
dc.title[13C]-Urea breath test without prior fasting and without test meal is accurate for the detection of Helicobacter pylori infection in Chinese
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. Ruttonjee Hospital Hong Kong