Article: [13C]-Urea breath test without prior fasting and without test meal is accurate for the detection of Helicobacter pylori infection in Chinese

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Title[13C]-Urea breath test without prior fasting and without test meal is accurate for the detection of Helicobacter pylori infection in Chinese
AuthorsNg, FH2
Lai, KC
Wong, BCY1
Wong, WM
Wong, SY2
Chow, KC2
Yuen, ST1
Leung, SY1
Lam, SK
Keywords[13C]-urea breath test
Chinese
Helicobacter pylori
Non-fasting
Test meal
Issue Date2002
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGH
CitationJournal Of Gastroenterology And Hepatology, 2002, v. 17 n. 8, p. 834-838 [How to Cite?]
DOI: http://dx.doi.org/10.1046/j.1440-1746.2002.02833.x
AbstractBackground and Aim: Conventional [13C]-urea breath test ([13C]-UBT) requires prior fasting and a test meal, which theoretically improves the accuracy of the test. However, recent studies have suggested that prior fasting and test meal may not be essential. We aimed to determine the accuracy of a new [13C]-UBT protocol without fasting in Chinese. Methods: Dyspeptic patients referred for upper endoscopy were recruited. The gold standard for Helicobacter pylori infection was the combination of Campylobacter-like organism (CLO) test and histology. Group I (n = 213) patients underwent [13C]-UBT with prior fasting and with citrate acid test meal. Group II (n = 123) patients underwent [13C]-UBT without prior fasting but with test meal. Group III (n = 90) patients underwent [13C]-UBT without prior fasting and without test meal. Results: The highest accuracy for groups I, II and III was 96.7, 95.1 and 95.5% using a cut-off value of 5.0, 5.5 and 3.5, respectively. The sensitivities and specificities were 97.4 and 95.8% in group I, 93.3 and 96.8% in group II, and 96.5 and 93.9% in group III, respectively. Conclusion: The [13C]-UBT protocols without prior fasting and either with or without test meal produce highly accurate and reliable results in the Chinese population. © 2002 Blackwell Publishing Asia Pty Ltd.
ISSN0815-9319
2011 Impact Factor: 2.865
2011 SCImago Journal Rankings: 0.208
DOIhttp://dx.doi.org/10.1046/j.1440-1746.2002.02833.x
ISI Accession Number IDWOS:000177282100005
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorNg, FH
dc.contributor.authorLai, KC
dc.contributor.authorWong, BCY
dc.contributor.authorWong, WM
dc.contributor.authorWong, SY
dc.contributor.authorChow, KC
dc.contributor.authorYuen, ST
dc.contributor.authorLeung, SY
dc.contributor.authorLam, SK
dc.date.accessioned2010-09-06T07:26:27Z
dc.date.available2010-09-06T07:26:27Z
dc.date.issued2002
dc.description.abstractBackground and Aim: Conventional [13C]-urea breath test ([13C]-UBT) requires prior fasting and a test meal, which theoretically improves the accuracy of the test. However, recent studies have suggested that prior fasting and test meal may not be essential. We aimed to determine the accuracy of a new [13C]-UBT protocol without fasting in Chinese. Methods: Dyspeptic patients referred for upper endoscopy were recruited. The gold standard for Helicobacter pylori infection was the combination of Campylobacter-like organism (CLO) test and histology. Group I (n = 213) patients underwent [13C]-UBT with prior fasting and with citrate acid test meal. Group II (n = 123) patients underwent [13C]-UBT without prior fasting but with test meal. Group III (n = 90) patients underwent [13C]-UBT without prior fasting and without test meal. Results: The highest accuracy for groups I, II and III was 96.7, 95.1 and 95.5% using a cut-off value of 5.0, 5.5 and 3.5, respectively. The sensitivities and specificities were 97.4 and 95.8% in group I, 93.3 and 96.8% in group II, and 96.5 and 93.9% in group III, respectively. Conclusion: The [13C]-UBT protocols without prior fasting and either with or without test meal produce highly accurate and reliable results in the Chinese population. © 2002 Blackwell Publishing Asia Pty Ltd.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationJournal Of Gastroenterology And Hepatology, 2002, v. 17 n. 8, p. 834-838 [How to Cite?]
DOI: http://dx.doi.org/10.1046/j.1440-1746.2002.02833.x
dc.identifier.doihttp://dx.doi.org/10.1046/j.1440-1746.2002.02833.x
dc.identifier.epage838
dc.identifier.hkuros81947
dc.identifier.isiWOS:000177282100005
dc.identifier.issn0815-9319
2011 Impact Factor: 2.865
2011 SCImago Journal Rankings: 0.208
dc.identifier.issue8
dc.identifier.openurl
dc.identifier.pmid12164957
dc.identifier.scopuseid_2-s2.0-0036025161
dc.identifier.spage834
dc.identifier.urihttp://hdl.handle.net/10722/76930
dc.identifier.volume17
dc.languageeng
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGH
dc.publisher.placeAustralia
dc.relation.ispartofJournal of Gastroenterology and Hepatology
dc.relation.referencesReferences in Scopus
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshBreath Tests
dc.subject.meshCarbon Isotopes - analysis - diagnostic use
dc.subject.meshChina
dc.subject.meshEating
dc.subject.meshFasting
dc.subject.meshFemale
dc.subject.meshHelicobacter Infections - diagnosis
dc.subject.meshHelicobacter pylori - isolation & purification
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshReproducibility of Results
dc.subject.meshSensitivity and Specificity
dc.subject.meshUrea - analysis - diagnostic use
dc.subject[13C]-urea breath test
dc.subjectChinese
dc.subjectHelicobacter pylori
dc.subjectNon-fasting
dc.subjectTest meal
dc.title[13C]-Urea breath test without prior fasting and without test meal is accurate for the detection of Helicobacter pylori infection in Chinese
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Ruttonjee Hospital Hong Kong