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Article: Moderate wine consumption in the prevention of metabolic syndrome and its related medical complications

TitleModerate wine consumption in the prevention of metabolic syndrome and its related medical complications
Authors
KeywordsAnti-Oxidant
Calorie Restriction
Ethanol
HDL-cholesterol
Nitric oxide bioavailability
Polyphenols
Issue Date2008
PublisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cdtiemd/index.htm
Citation
Endocrine, Metabolic And Immune Disorders - Drug Targets, 2008, v. 8 n. 2, p. 89-98 How to Cite?
AbstractThe metabolic syndrome (MetS) encompasses a constellation of cardio-metabolic abnormalities associated with a high risk of developing type 2 diabetes and cardiovascular disease (CVD), the top killer in the ageing population. Recent studies have demonstrated multiple beneficial effects of moderate wine consumption in the protection against development of the MetS and its related medical complications. The association of moderate wine consumption with lower incidence of the MetS and atherosclerotic heart disease has been repeatedly documented in numerous epidemiological studies on diverse ethnic groups. In addition to the favorable effects of moderate ethanol intake on lipid profiles, polyphenols enriched in red wine possess multiple benefits on the MetS beyond alcohol through their anti-oxidant, anti-inflammatory, vascular-protective and insulin-sensitizing properties. Notable among these red wine polypheolic compounds is resveratrol, a phytoalexin that has recently attracted great attention due to its role in mimicking calorie restriction. This compound can act as a potent activator of the NAD+-dependent deacetylases sirtuins to expand the life span and to prevent the deleterious effects of excess intake on insulin resistance and metabolic derangement. In addition, resveratrol exerts its multiple protective effects against the MetS through stimulating AMP-activated protein kinase and promoting mitochondria biogenesis. In this review, we highlight the recent epidemiological and experimental evidences supporting the protective effects of moderate wine intake against the MetS and its associated cardio-metabolic complications, and discuss the molecular mechanisms underlying the multiple beneficial actions of red wine polyphenols with the focus on resveratrol. © 2008 Bentham Science Publishers Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/76840
ISSN
2015 Impact Factor: 1.987
2015 SCImago Journal Rankings: 0.717
References

 

DC FieldValueLanguage
dc.contributor.authorLiu, Len_HK
dc.contributor.authorWang, Yen_HK
dc.contributor.authorLam, KSLen_HK
dc.contributor.authorXu, Aen_HK
dc.date.accessioned2010-09-06T07:25:28Z-
dc.date.available2010-09-06T07:25:28Z-
dc.date.issued2008en_HK
dc.identifier.citationEndocrine, Metabolic And Immune Disorders - Drug Targets, 2008, v. 8 n. 2, p. 89-98en_HK
dc.identifier.issn1871-5303en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76840-
dc.description.abstractThe metabolic syndrome (MetS) encompasses a constellation of cardio-metabolic abnormalities associated with a high risk of developing type 2 diabetes and cardiovascular disease (CVD), the top killer in the ageing population. Recent studies have demonstrated multiple beneficial effects of moderate wine consumption in the protection against development of the MetS and its related medical complications. The association of moderate wine consumption with lower incidence of the MetS and atherosclerotic heart disease has been repeatedly documented in numerous epidemiological studies on diverse ethnic groups. In addition to the favorable effects of moderate ethanol intake on lipid profiles, polyphenols enriched in red wine possess multiple benefits on the MetS beyond alcohol through their anti-oxidant, anti-inflammatory, vascular-protective and insulin-sensitizing properties. Notable among these red wine polypheolic compounds is resveratrol, a phytoalexin that has recently attracted great attention due to its role in mimicking calorie restriction. This compound can act as a potent activator of the NAD+-dependent deacetylases sirtuins to expand the life span and to prevent the deleterious effects of excess intake on insulin resistance and metabolic derangement. In addition, resveratrol exerts its multiple protective effects against the MetS through stimulating AMP-activated protein kinase and promoting mitochondria biogenesis. In this review, we highlight the recent epidemiological and experimental evidences supporting the protective effects of moderate wine intake against the MetS and its associated cardio-metabolic complications, and discuss the molecular mechanisms underlying the multiple beneficial actions of red wine polyphenols with the focus on resveratrol. © 2008 Bentham Science Publishers Ltd.en_HK
dc.languageengen_HK
dc.publisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cdtiemd/index.htmen_HK
dc.relation.ispartofEndocrine, Metabolic and Immune Disorders - Drug Targetsen_HK
dc.subjectAnti-Oxidanten_HK
dc.subjectCalorie Restrictionen_HK
dc.subjectEthanolen_HK
dc.subjectHDL-cholesterolen_HK
dc.subjectNitric oxide bioavailabilityen_HK
dc.subjectPolyphenolsen_HK
dc.subject.meshAlcohol Drinking - metabolismen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAntioxidants - chemistry - pharmacologyen_HK
dc.subject.meshCardiovascular Diseases - epidemiologyen_HK
dc.subject.meshDiabetes Mellitus, Type 2 - epidemiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshInsulin Resistance - physiologyen_HK
dc.subject.meshMetabolic Syndrome X - complications - prevention & controlen_HK
dc.subject.meshRandomized Controlled Trials as Topicen_HK
dc.subject.meshStilbenes - chemistry - pharmacologyen_HK
dc.subject.meshWine - analysisen_HK
dc.titleModerate wine consumption in the prevention of metabolic syndrome and its related medical complicationsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1871-5303&volume=8&spage=89&epage=98&date=2008&atitle=Moderate+wine+consumption+in+the+prevention+of+metabolic+syndrome+and+its+related+medical+complicationsen_HK
dc.identifier.emailWang, Y: yuwanghk@hku.hken_HK
dc.identifier.emailLam, KSL: ksllam@hku.hken_HK
dc.identifier.emailXu, A: amxu@hkucc.hku.hken_HK
dc.identifier.authorityWang, Y=rp00239en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.identifier.authorityXu, A=rp00485en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.2174/187153008784534385en_HK
dc.identifier.pmid18537695-
dc.identifier.scopuseid_2-s2.0-47249116481en_HK
dc.identifier.hkuros145455en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-47249116481&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume8en_HK
dc.identifier.issue2en_HK
dc.identifier.spage89en_HK
dc.identifier.epage98en_HK
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridLiu, L=21737444900en_HK
dc.identifier.scopusauthoridWang, Y=34973733700en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK
dc.identifier.scopusauthoridXu, A=7202655409en_HK
dc.identifier.citeulike2868791-

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