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Article: Determinants of postprandial triglyceride and remnant-like lipoproteins in type 2 diabetes

TitleDeterminants of postprandial triglyceride and remnant-like lipoproteins in type 2 diabetes
Authors
KeywordsApolipoprotein E polymorphism
Insulin resistance
Postprandial lipemia
Remnant-like lipoproteins
Type 2 diabetes
Issue Date2005
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/10009394
Citation
Diabetes/Metabolism Research And Reviews, 2005, v. 21 n. 2, p. 209-214 How to Cite?
AbstractBackground: Postprandial changes in remnant-like lipoprotein particles (RLP) contribute to the severity of coronary heart disease in type 2 diabetes. Since the determinants of postprandial response in RLP are not well understood, this study investigated the roles of fasting triglyceride, apolipoprotein (apo) E polymorphism and insulin resistance in a group of overweight/obese Chinese type 2 diabetic subjects. Methods: Postprandial triglyceride (TG) and RLP-cholesterol (RLP-C) were determined after a mixed meal containing 70-g fat at 2-h intervals for 8 h in 32 normotriglyceridemic (NTG) and 31 hypertriglyceridemic (HTG) subjects. RLP-C was measured using an immunoseparation assay and apo E genotypes using polymerase chain reaction and restriction mapping. Insulin resistance was defined as homeostasis model assessment index (HOMA-IR). Results: The HTG subjects had greater postprandial increase in TG and RLP-C than NTG (p < 0.001), but there were no significant differences in HOMA-IR and apo E allele frequencies. Subjects who were non-E3-carriers had the largest postprandial increment in TG and RLP-C. On stepwise linear regression analysis, log(HOMA-IR) was only an independent determinant of fasting TG but not postprandial TG or RLP-C. The major determinants of fasting and postprandial RLP-C were fasting TG and apo E genotype, accounting for 53 and 6% of the variance of fasting RLP-C (p < 0.01) and 31 and 13% of the variance of postprandial RLP-C respectively (p < 0.01). Conclusions: Insulin resistance is mainly a determinant of fasting triglyceride in Chinese type 2 diabetic subjects, whereas apo E genotype is a better predictor of both fasting and postprandial concentrations of RLP. Copyright © 2005 John Wiley & Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/76812
ISSN
2012 Impact Factor: 2.968
2015 SCImago Journal Rankings: 1.617
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTan, KCBen_HK
dc.contributor.authorTso, AWKen_HK
dc.contributor.authorMa, OCKen_HK
dc.contributor.authorPang, RWCen_HK
dc.contributor.authorLam, KSLen_HK
dc.date.accessioned2010-09-06T07:25:11Z-
dc.date.available2010-09-06T07:25:11Z-
dc.date.issued2005en_HK
dc.identifier.citationDiabetes/Metabolism Research And Reviews, 2005, v. 21 n. 2, p. 209-214en_HK
dc.identifier.issn1520-7552en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76812-
dc.description.abstractBackground: Postprandial changes in remnant-like lipoprotein particles (RLP) contribute to the severity of coronary heart disease in type 2 diabetes. Since the determinants of postprandial response in RLP are not well understood, this study investigated the roles of fasting triglyceride, apolipoprotein (apo) E polymorphism and insulin resistance in a group of overweight/obese Chinese type 2 diabetic subjects. Methods: Postprandial triglyceride (TG) and RLP-cholesterol (RLP-C) were determined after a mixed meal containing 70-g fat at 2-h intervals for 8 h in 32 normotriglyceridemic (NTG) and 31 hypertriglyceridemic (HTG) subjects. RLP-C was measured using an immunoseparation assay and apo E genotypes using polymerase chain reaction and restriction mapping. Insulin resistance was defined as homeostasis model assessment index (HOMA-IR). Results: The HTG subjects had greater postprandial increase in TG and RLP-C than NTG (p < 0.001), but there were no significant differences in HOMA-IR and apo E allele frequencies. Subjects who were non-E3-carriers had the largest postprandial increment in TG and RLP-C. On stepwise linear regression analysis, log(HOMA-IR) was only an independent determinant of fasting TG but not postprandial TG or RLP-C. The major determinants of fasting and postprandial RLP-C were fasting TG and apo E genotype, accounting for 53 and 6% of the variance of fasting RLP-C (p < 0.01) and 31 and 13% of the variance of postprandial RLP-C respectively (p < 0.01). Conclusions: Insulin resistance is mainly a determinant of fasting triglyceride in Chinese type 2 diabetic subjects, whereas apo E genotype is a better predictor of both fasting and postprandial concentrations of RLP. Copyright © 2005 John Wiley & Sons, Ltd.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/10009394en_HK
dc.relation.ispartofDiabetes/Metabolism Research and Reviewsen_HK
dc.rightsDiabetes - Metabolism: Research and Reviews. Copyright © John Wiley & Sons Ltd.en_HK
dc.subjectApolipoprotein E polymorphismen_HK
dc.subjectInsulin resistanceen_HK
dc.subjectPostprandial lipemiaen_HK
dc.subjectRemnant-like lipoproteinsen_HK
dc.subjectType 2 diabetesen_HK
dc.subject.meshAdulten_HK
dc.subject.meshBody Mass Indexen_HK
dc.subject.meshDiabetes Mellitus, Type 2 - blood - complicationsen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHemoglobin A, Glycosylated - analysisen_HK
dc.subject.meshHumansen_HK
dc.subject.meshHypertriglyceridemia - blood - complicationsen_HK
dc.subject.meshLipids - blooden_HK
dc.subject.meshLipoproteins - blooden_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPeptide Fragments - blooden_HK
dc.subject.meshPostprandial Perioden_HK
dc.subject.meshTriglycerides - blooden_HK
dc.titleDeterminants of postprandial triglyceride and remnant-like lipoproteins in type 2 diabetesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1520-7552&volume=21&issue=2&spage=209&epage=14&date=2005&atitle=Determinants+of+postprandial+triglyceride+and+remnant-like+lipoproteins+in+type+2+diabetesen_HK
dc.identifier.emailTan, KCB: kcbtan@hku.hken_HK
dc.identifier.emailTso, AWK: awk.tso@gmail.comen_HK
dc.identifier.emailPang, RWC: robertap@hku.hken_HK
dc.identifier.emailLam, KSL: ksllam@hku.hken_HK
dc.identifier.authorityTan, KCB=rp00402en_HK
dc.identifier.authorityTso, AWK=rp00535en_HK
dc.identifier.authorityPang, RWC=rp00274en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/dmrr.504en_HK
dc.identifier.pmid15386805-
dc.identifier.scopuseid_2-s2.0-16344364320en_HK
dc.identifier.hkuros98206en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-16344364320&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume21en_HK
dc.identifier.issue2en_HK
dc.identifier.spage209en_HK
dc.identifier.epage214en_HK
dc.identifier.isiWOS:000227938800014-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridTan, KCB=8082703100en_HK
dc.identifier.scopusauthoridTso, AWK=6701371436en_HK
dc.identifier.scopusauthoridMa, OCK=7004452841en_HK
dc.identifier.scopusauthoridPang, RWC=7004376659en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK

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