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Article: Antralization at the edge of proximal gastric ulcers: Does Helicobacter pylori infection play a role?
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TitleAntralization at the edge of proximal gastric ulcers: Does Helicobacter pylori infection play a role?
 
AuthorsXia, HHX1
Lam, SK1
Wong, WM1
Hu, WHC1
Lai, KC1
Wong, SH1
Leung, SY1
Yuen, ST1
Wright, NA2
Wong, BCY1
 
Issue Date2003
 
PublisherBeijing Baishideng BioMed Scientific Co., Ltd. The Journal's web site is located at http://www.wjgnet.com/1007-9327/index.htm
 
CitationWorld Journal Of Gastroenterology, 2003, v. 9 n. 6, p. 1265-1269 [How to Cite?]
 
AbstractAim: To determine the prevalence of antralization at the edge of proximal gastric ulcers, and the effect of H. pylori eradication on the mucosal appearances. Methods: Biopsies were taken from the antrum, body and the ulcer edge of patients with benign proximal gastric ulcers before and one year after treatment. Gastric mucosa was classified as antral, transitional or body type. H. pylori positive patients received either triple therapy, or omeprazole. Results: Patients with index ulcers in the incisura, body or fundus (n=116) were analyzed. Antral-type mucosa was more prevalent at the ulcer edge in H. pylori-positive patients than H. pylori-negative patients (93 % vs 60 %, OR=8.95, 95 %CI: 2.47-32.4, P=0.001). At one year, there was a significant reduction in the prevalence of antralization (from 93 % to 61 %, P=0.004) at the ulcer edge in patients with H. pylori being eradicated. However, there was no difference in the prevalence of antralization at the ulcer edge in those with persistent infection. Conclusion: H. pylori infection is associated with antralization at the edge of proximal gastric ulcers, which may be reversible in some patients after eradication of the infection.
 
ISSN1007-9327
2013 Impact Factor: 2.433
2013 SCImago Journal Rankings: 1.022
 
ISI Accession Number IDWOS:000183763000026
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorXia, HHX
 
dc.contributor.authorLam, SK
 
dc.contributor.authorWong, WM
 
dc.contributor.authorHu, WHC
 
dc.contributor.authorLai, KC
 
dc.contributor.authorWong, SH
 
dc.contributor.authorLeung, SY
 
dc.contributor.authorYuen, ST
 
dc.contributor.authorWright, NA
 
dc.contributor.authorWong, BCY
 
dc.date.accessioned2010-09-06T07:24:00Z
 
dc.date.available2010-09-06T07:24:00Z
 
dc.date.issued2003
 
dc.description.abstractAim: To determine the prevalence of antralization at the edge of proximal gastric ulcers, and the effect of H. pylori eradication on the mucosal appearances. Methods: Biopsies were taken from the antrum, body and the ulcer edge of patients with benign proximal gastric ulcers before and one year after treatment. Gastric mucosa was classified as antral, transitional or body type. H. pylori positive patients received either triple therapy, or omeprazole. Results: Patients with index ulcers in the incisura, body or fundus (n=116) were analyzed. Antral-type mucosa was more prevalent at the ulcer edge in H. pylori-positive patients than H. pylori-negative patients (93 % vs 60 %, OR=8.95, 95 %CI: 2.47-32.4, P=0.001). At one year, there was a significant reduction in the prevalence of antralization (from 93 % to 61 %, P=0.004) at the ulcer edge in patients with H. pylori being eradicated. However, there was no difference in the prevalence of antralization at the ulcer edge in those with persistent infection. Conclusion: H. pylori infection is associated with antralization at the edge of proximal gastric ulcers, which may be reversible in some patients after eradication of the infection.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationWorld Journal Of Gastroenterology, 2003, v. 9 n. 6, p. 1265-1269 [How to Cite?]
 
dc.identifier.epage1269
 
dc.identifier.hkuros80443
 
dc.identifier.isiWOS:000183763000026
 
dc.identifier.issn1007-9327
2013 Impact Factor: 2.433
2013 SCImago Journal Rankings: 1.022
 
dc.identifier.issue6
 
dc.identifier.openurl
 
dc.identifier.pmid12800237
 
dc.identifier.scopuseid_2-s2.0-0037713705
 
dc.identifier.spage1265
 
dc.identifier.urihttp://hdl.handle.net/10722/76699
 
dc.identifier.volume9
 
dc.languageeng
 
dc.publisherBeijing Baishideng BioMed Scientific Co., Ltd. The Journal's web site is located at http://www.wjgnet.com/1007-9327/index.htm
 
dc.publisher.placeChina
 
dc.relation.ispartofWorld Journal of Gastroenterology
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAged
 
dc.subject.meshAnti-Bacterial Agents
 
dc.subject.meshAnti-Ulcer Agents - therapeutic use
 
dc.subject.meshDrug Therapy, Combination - therapeutic use
 
dc.subject.meshFemale
 
dc.subject.meshGastric Mucosa - pathology
 
dc.subject.meshHelicobacter Infections - complications - drug therapy
 
dc.subject.meshHelicobacter pylori
 
dc.subject.meshHumans
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshOmeprazole - therapeutic use
 
dc.subject.meshPyloric Antrum - pathology
 
dc.subject.meshStomach Ulcer - drug therapy - microbiology - pathology
 
dc.titleAntralization at the edge of proximal gastric ulcers: Does Helicobacter pylori infection play a role?
 
dc.typeArticle
 
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<contributor.author>Hu, WHC</contributor.author>
<contributor.author>Lai, KC</contributor.author>
<contributor.author>Wong, SH</contributor.author>
<contributor.author>Leung, SY</contributor.author>
<contributor.author>Yuen, ST</contributor.author>
<contributor.author>Wright, NA</contributor.author>
<contributor.author>Wong, BCY</contributor.author>
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<description.abstract>Aim: To determine the prevalence of antralization at the edge of proximal gastric ulcers, and the effect of H. pylori eradication on the mucosal appearances. Methods: Biopsies were taken from the antrum, body and the ulcer edge of patients with benign proximal gastric ulcers before and one year after treatment. Gastric mucosa was classified as antral, transitional or body type. H. pylori positive patients received either triple therapy, or omeprazole. Results: Patients with index ulcers in the incisura, body or fundus (n=116) were analyzed. Antral-type mucosa was more prevalent at the ulcer edge in H. pylori-positive patients than H. pylori-negative patients (93 % vs 60 %, OR=8.95, 95 %CI: 2.47-32.4, P=0.001). At one year, there was a significant reduction in the prevalence of antralization (from 93 % to 61 %, P=0.004) at the ulcer edge in patients with H. pylori being eradicated. However, there was no difference in the prevalence of antralization at the ulcer edge in those with persistent infection. Conclusion: H. pylori infection is associated with antralization at the edge of proximal gastric ulcers, which may be reversible in some patients after eradication of the infection.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong
  2. Lawson Health Research Institute