Article: Antralization at the edge of proximal gastric ulcers: Does Helicobacter pylori infection play a role?

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TitleAntralization at the edge of proximal gastric ulcers: Does Helicobacter pylori infection play a role?
AuthorsXia, HHX1
Lam, SK1
Wong, WM1
Hu, WHC1
Lai, KC1
Wong, SH1
Leung, SY1
Yuen, ST1
Wright, NA2
Wong, BCY1
Issue Date2003
PublisherBeijing Baishideng BioMed Scientific Co., Ltd. The Journal's web site is located at http://www.wjgnet.com/1007-9327/index.htm
CitationWorld Journal Of Gastroenterology, 2003, v. 9 n. 6, p. 1265-1269 [How to Cite?]
AbstractAim: To determine the prevalence of antralization at the edge of proximal gastric ulcers, and the effect of H. pylori eradication on the mucosal appearances. Methods: Biopsies were taken from the antrum, body and the ulcer edge of patients with benign proximal gastric ulcers before and one year after treatment. Gastric mucosa was classified as antral, transitional or body type. H. pylori positive patients received either triple therapy, or omeprazole. Results: Patients with index ulcers in the incisura, body or fundus (n=116) were analyzed. Antral-type mucosa was more prevalent at the ulcer edge in H. pylori-positive patients than H. pylori-negative patients (93 % vs 60 %, OR=8.95, 95 %CI: 2.47-32.4, P=0.001). At one year, there was a significant reduction in the prevalence of antralization (from 93 % to 61 %, P=0.004) at the ulcer edge in patients with H. pylori being eradicated. However, there was no difference in the prevalence of antralization at the ulcer edge in those with persistent infection. Conclusion: H. pylori infection is associated with antralization at the edge of proximal gastric ulcers, which may be reversible in some patients after eradication of the infection.
ISSN1007-9327
2011 Impact Factor: 2.471
2011 SCImago Journal Rankings: 0.189
ISI Accession Number IDWOS:000183763000026
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorXia, HHX
dc.contributor.authorLam, SK
dc.contributor.authorWong, WM
dc.contributor.authorHu, WHC
dc.contributor.authorLai, KC
dc.contributor.authorWong, SH
dc.contributor.authorLeung, SY
dc.contributor.authorYuen, ST
dc.contributor.authorWright, NA
dc.contributor.authorWong, BCY
dc.date.accessioned2010-09-06T07:24:00Z
dc.date.available2010-09-06T07:24:00Z
dc.date.issued2003
dc.description.abstractAim: To determine the prevalence of antralization at the edge of proximal gastric ulcers, and the effect of H. pylori eradication on the mucosal appearances. Methods: Biopsies were taken from the antrum, body and the ulcer edge of patients with benign proximal gastric ulcers before and one year after treatment. Gastric mucosa was classified as antral, transitional or body type. H. pylori positive patients received either triple therapy, or omeprazole. Results: Patients with index ulcers in the incisura, body or fundus (n=116) were analyzed. Antral-type mucosa was more prevalent at the ulcer edge in H. pylori-positive patients than H. pylori-negative patients (93 % vs 60 %, OR=8.95, 95 %CI: 2.47-32.4, P=0.001). At one year, there was a significant reduction in the prevalence of antralization (from 93 % to 61 %, P=0.004) at the ulcer edge in patients with H. pylori being eradicated. However, there was no difference in the prevalence of antralization at the ulcer edge in those with persistent infection. Conclusion: H. pylori infection is associated with antralization at the edge of proximal gastric ulcers, which may be reversible in some patients after eradication of the infection.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationWorld Journal Of Gastroenterology, 2003, v. 9 n. 6, p. 1265-1269 [How to Cite?]
dc.identifier.epage1269
dc.identifier.hkuros80443
dc.identifier.isiWOS:000183763000026
dc.identifier.issn1007-9327
2011 Impact Factor: 2.471
2011 SCImago Journal Rankings: 0.189
dc.identifier.issue6
dc.identifier.openurl
dc.identifier.pmid12800237
dc.identifier.scopuseid_2-s2.0-0037713705
dc.identifier.spage1265
dc.identifier.urihttp://hdl.handle.net/10722/76699
dc.identifier.volume9
dc.languageeng
dc.publisherBeijing Baishideng BioMed Scientific Co., Ltd. The Journal's web site is located at http://www.wjgnet.com/1007-9327/index.htm
dc.publisher.placeChina
dc.relation.ispartofWorld Journal of Gastroenterology
dc.relation.referencesReferences in Scopus
dc.subject.meshAged
dc.subject.meshAnti-Bacterial Agents
dc.subject.meshAnti-Ulcer Agents - therapeutic use
dc.subject.meshDrug Therapy, Combination - therapeutic use
dc.subject.meshFemale
dc.subject.meshGastric Mucosa - pathology
dc.subject.meshHelicobacter Infections - complications - drug therapy
dc.subject.meshHelicobacter pylori
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshOmeprazole - therapeutic use
dc.subject.meshPyloric Antrum - pathology
dc.subject.meshStomach Ulcer - drug therapy - microbiology - pathology
dc.titleAntralization at the edge of proximal gastric ulcers: Does Helicobacter pylori infection play a role?
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Lawson Health Research Institute