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Article: Adrenal pheochromocytoma remains a frequently overlooked diagnosis

TitleAdrenal pheochromocytoma remains a frequently overlooked diagnosis
Authors
Issue Date2000
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/amjsurg
Citation
American Journal Of Surgery, 2000, v. 179 n. 3, p. 212-215 How to Cite?
AbstractBackground: Adrenal pheochromocytoma is potentially lethal if undetected and is associated with long-term morbidity. Methods: Records of patients (11 men, 18 women) with confirmed pheochromocytoma were studied with respect to clinicopathological features and outcome. Results: Pheochromocytoma was diagnosed in 4 of 8,486 (0.05%) autopsies and accounted for 3 of the 4 immediate causes of death. Operative mortality occurred in 1 patient with undiagnosed tumor. Hypertensive-related complications occurred in 6 patients before diagnosis. Malignancy was documented in 7 patients with distant metastases (n = 4) or locally invasive tumors (n = 3). During a median follow-up of 4 years, 23 patients are alive and free of disease (79%). Four of the 6 patients (67%) who died had distant metastases compared with 2 of 23 patients (9%) without distant metastases (P = 0.04). Persistent hypertension and diabetes requiring treatment were present in 8 (35%) and 4 (17%) of 23 patients respectively. Conclusions: Fatal complications preceded diagnosis in a significant proportion of patients with pheochromocytoma. The presence of distant metastases was associated with poor survival. Copyright (C) 2000 Excerpta Medica Inc.
Persistent Identifierhttp://hdl.handle.net/10722/76592
ISSN
2015 Impact Factor: 2.403
2015 SCImago Journal Rankings: 1.286
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLo, CYen_HK
dc.contributor.authorLam, KYen_HK
dc.contributor.authorWat, MSen_HK
dc.contributor.authorLam, KSen_HK
dc.date.accessioned2010-09-06T07:22:52Z-
dc.date.available2010-09-06T07:22:52Z-
dc.date.issued2000en_HK
dc.identifier.citationAmerican Journal Of Surgery, 2000, v. 179 n. 3, p. 212-215en_HK
dc.identifier.issn0002-9610en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76592-
dc.description.abstractBackground: Adrenal pheochromocytoma is potentially lethal if undetected and is associated with long-term morbidity. Methods: Records of patients (11 men, 18 women) with confirmed pheochromocytoma were studied with respect to clinicopathological features and outcome. Results: Pheochromocytoma was diagnosed in 4 of 8,486 (0.05%) autopsies and accounted for 3 of the 4 immediate causes of death. Operative mortality occurred in 1 patient with undiagnosed tumor. Hypertensive-related complications occurred in 6 patients before diagnosis. Malignancy was documented in 7 patients with distant metastases (n = 4) or locally invasive tumors (n = 3). During a median follow-up of 4 years, 23 patients are alive and free of disease (79%). Four of the 6 patients (67%) who died had distant metastases compared with 2 of 23 patients (9%) without distant metastases (P = 0.04). Persistent hypertension and diabetes requiring treatment were present in 8 (35%) and 4 (17%) of 23 patients respectively. Conclusions: Fatal complications preceded diagnosis in a significant proportion of patients with pheochromocytoma. The presence of distant metastases was associated with poor survival. Copyright (C) 2000 Excerpta Medica Inc.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/amjsurgen_HK
dc.relation.ispartofAmerican Journal of Surgeryen_HK
dc.rightsThe American Journal of Surgery. Copyright © Elsevier Inc.en_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdrenal Gland Neoplasms - complications - diagnosis - surgeryen_HK
dc.subject.meshAdrenalectomyen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAutopsyen_HK
dc.subject.meshCause of Deathen_HK
dc.subject.meshDNA, Neoplasm - geneticsen_HK
dc.subject.meshDiabetes Complicationsen_HK
dc.subject.meshDiagnosis, Differentialen_HK
dc.subject.meshDisease-Free Survivalen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFollow-Up Studiesen_HK
dc.subject.meshHumansen_HK
dc.subject.meshHypertension - etiologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMetanephrine - urineen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNeoplasm Invasivenessen_HK
dc.subject.meshNeoplasm Recurrence, Local - pathologyen_HK
dc.subject.meshPheochromocytoma - complications - diagnosis - secondary - surgeryen_HK
dc.subject.meshPloidiesen_HK
dc.subject.meshPostoperative Complicationsen_HK
dc.subject.meshRetrospective Studiesen_HK
dc.subject.meshTreatment Outcomeen_HK
dc.subject.meshVanilmandelic Acid - urineen_HK
dc.titleAdrenal pheochromocytoma remains a frequently overlooked diagnosisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0002-9610&volume=179&spage=212&epage=215&date=2000&atitle=Adrenal+pheochromocytoma+remains+a+frequently+overlooked+diagnosisen_HK
dc.identifier.emailLam, KS:ksllam@hku.hken_HK
dc.identifier.authorityLam, KS=rp00343en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0002-9610(00)00296-8en_HK
dc.identifier.pmid10827323-
dc.identifier.scopuseid_2-s2.0-0034026702en_HK
dc.identifier.hkuros48771en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034026702&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume179en_HK
dc.identifier.issue3en_HK
dc.identifier.spage212en_HK
dc.identifier.epage215en_HK
dc.identifier.isiWOS:000087285700014-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLo, CY=16417392800en_HK
dc.identifier.scopusauthoridLam, KY=7403657165en_HK
dc.identifier.scopusauthoridWat, MS=6603247639en_HK
dc.identifier.scopusauthoridLam, KS=8082870600en_HK

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