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Article: Early detection of hepatocellular carcinoma increases the chance of treatment: Hong kong experience

TitleEarly detection of hepatocellular carcinoma increases the chance of treatment: Hong kong experience
Authors
Issue Date2000
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.hepatology.org/
Citation
Hepatology, 2000, v. 31 n. 2, p. 330-335 How to Cite?
AbstractThe prognosis for patients with hepatocellular carcinoma (HCC) is poor because of the low chance of curative treatment. To increase the chance of intervention and to improve survival, early detection of subclinical HCC (SCHCC) by α-fetoprotein (AFP) and/or ultrasonography (USG) screening is implemented in many countries. Three hundred six Chinese patients with HCC diagnosed between January 1995 and December 1997 were recruited. They were categorized into two groups: 142 patients (group 1) had SCHCC diagnosed by screening (AFP and/or USG), and 164 patients (group 2) presented with symptomatic HCC. The tumor size was significantly smaller in group I compared with that of group 2 (3.5 cm vs. 8.1 cm; P < .0001). A significantly higher proportion of patients had bilobar involvement, multifocal HCC, diffuse-type HCC, portal vein infiltration, and distant metastasis in group 2 when compared with group 1. Operability and feasibility of treatment by transcatheter intra-arterial chemoembolization (TACE) in group I patients (26.8% and 45.1%, respectively) were significantly better than in group 2 patients (7.9% and 32.3%, P < .0001 and P = .03, respectively). The cumulative survival rate was significantly higher in group 1 than in group 2 (P < .0001). For those who had surgical resection and those who had TACE, group I patients had a higher cumulative survival rate compared with that of group 2 patients (P = .04 and P = .0003, respectively). Screening for HCC by AFP and/or USG can identify tumors at an early stage, resulting in a higher chance of receiving treatment. Whether it can improve survival requires a further prospective, randomized study.
Persistent Identifierhttp://hdl.handle.net/10722/76582
ISSN
2015 Impact Factor: 11.711
2015 SCImago Journal Rankings: 4.752
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYuen, MFen_HK
dc.contributor.authorCheng, CCen_HK
dc.contributor.authorLauder, IJen_HK
dc.contributor.authorLam, SKen_HK
dc.contributor.authorOoi, CGCen_HK
dc.contributor.authorLai, CLen_HK
dc.date.accessioned2010-09-06T07:22:46Z-
dc.date.available2010-09-06T07:22:46Z-
dc.date.issued2000en_HK
dc.identifier.citationHepatology, 2000, v. 31 n. 2, p. 330-335en_HK
dc.identifier.issn0270-9139en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76582-
dc.description.abstractThe prognosis for patients with hepatocellular carcinoma (HCC) is poor because of the low chance of curative treatment. To increase the chance of intervention and to improve survival, early detection of subclinical HCC (SCHCC) by α-fetoprotein (AFP) and/or ultrasonography (USG) screening is implemented in many countries. Three hundred six Chinese patients with HCC diagnosed between January 1995 and December 1997 were recruited. They were categorized into two groups: 142 patients (group 1) had SCHCC diagnosed by screening (AFP and/or USG), and 164 patients (group 2) presented with symptomatic HCC. The tumor size was significantly smaller in group I compared with that of group 2 (3.5 cm vs. 8.1 cm; P < .0001). A significantly higher proportion of patients had bilobar involvement, multifocal HCC, diffuse-type HCC, portal vein infiltration, and distant metastasis in group 2 when compared with group 1. Operability and feasibility of treatment by transcatheter intra-arterial chemoembolization (TACE) in group I patients (26.8% and 45.1%, respectively) were significantly better than in group 2 patients (7.9% and 32.3%, P < .0001 and P = .03, respectively). The cumulative survival rate was significantly higher in group 1 than in group 2 (P < .0001). For those who had surgical resection and those who had TACE, group I patients had a higher cumulative survival rate compared with that of group 2 patients (P = .04 and P = .0003, respectively). Screening for HCC by AFP and/or USG can identify tumors at an early stage, resulting in a higher chance of receiving treatment. Whether it can improve survival requires a further prospective, randomized study.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.hepatology.org/en_HK
dc.relation.ispartofHepatologyen_HK
dc.rightsHepatology. Copyright © John Wiley & Sons, Inc.en_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshCarcinoma, Hepatocellular - diagnosis - physiopathology - therapy - ultrasonographyen_HK
dc.subject.meshCost-Benefit Analysisen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLiver - physiopathologyen_HK
dc.subject.meshLiver Function Testsen_HK
dc.subject.meshLiver Neoplasms - diagnosis - physiopathology - therapy - ultrasonographyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMass Screening - economicsen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshSurvival Analysisen_HK
dc.subject.meshTime Factorsen_HK
dc.subject.meshalpha-Fetoproteins - analysisen_HK
dc.titleEarly detection of hepatocellular carcinoma increases the chance of treatment: Hong kong experienceen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0270-9139&volume=31&issue=2&spage=330&epage=335&date=2000&atitle=Early+detection+of+hepatocellular+carcinoma+increases+the+chance+of+treatment:+Hong+Kong+experienceen_HK
dc.identifier.emailYuen, MF:mfyuen@hkucc.hku.hken_HK
dc.identifier.emailLai, CL:hrmelcl@hku.hken_HK
dc.identifier.authorityYuen, MF=rp00479en_HK
dc.identifier.authorityLai, CL=rp00314en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid10655254-
dc.identifier.scopuseid_2-s2.0-0033960899en_HK
dc.identifier.hkuros48371en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033960899&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume31en_HK
dc.identifier.issue2en_HK
dc.identifier.spage330en_HK
dc.identifier.epage335en_HK
dc.identifier.isiWOS:000085144000011-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridYuen, MF=7102031955en_HK
dc.identifier.scopusauthoridCheng, CC=7404796652en_HK
dc.identifier.scopusauthoridLauder, IJ=35564928000en_HK
dc.identifier.scopusauthoridLam, SK=7402279473en_HK
dc.identifier.scopusauthoridOoi, CGC=7007084909en_HK
dc.identifier.scopusauthoridLai, CL=7403086396en_HK

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