File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Peritoneal fibrosis - Future prevention strategies

TitlePeritoneal fibrosis - Future prevention strategies
Authors
KeywordsExtracellular matrix
Fibrosis
Glucose
Peritoneal dialysis
Peritoneum
Transforming growth factor-β1
Issue Date2003
PublisherLippincott Williams & Wilkins Asia. The Journal's web site is located at http://www.hkjn.org/
Citation
Hong Kong Journal Of Nephrology, 2003, v. 5 n. 1, p. 8-14 How to Cite?
AbstractPeritoneal fibrosis is one of the most serious complications of peritoneal dialysis, and is characterized by the activation of peritoneal resident cells (mesothelial cells, endothelial cells, fibroblasts and macrophages), induction of pro-fibrotic peptides, accumulation and deposition of excess matrix proteins within the submesothelium, and vasculopathy of the peritoneal microvasculature. In order to provide novel therapeutic strategies that will allow us to preserve the structural and functional integrity of the peritoneum during peritoneal dialysis, it is essential to elucidate the mechanisms of peritoneal fibrosis. There is now compelling evidence to show that elevated glucose concentrations present in peritoneal dialysis fluids and its by-products play a pivotal role in the initiation of peritoneal fibrosis. This review will describe the pathogenesis of glucose-mediated peritoneal fibrosis, and highlight recent in vitro data that may one day be extended to clinical trials, offering effective treatment in the preservation of the structure of the peritoneum. Such strategies include the employment of alterative osmotic agents (amino acids or icodextrin), transforming growth factor-β1 antagonists, gene therapy, and pharmacological intervention.
Persistent Identifierhttp://hdl.handle.net/10722/76491
ISSN
2015 SCImago Journal Rankings: 0.166
References

 

DC FieldValueLanguage
dc.contributor.authorYung, Sen_HK
dc.contributor.authorChan, TMen_HK
dc.date.accessioned2010-09-06T07:21:48Z-
dc.date.available2010-09-06T07:21:48Z-
dc.date.issued2003en_HK
dc.identifier.citationHong Kong Journal Of Nephrology, 2003, v. 5 n. 1, p. 8-14en_HK
dc.identifier.issn1561-5413en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76491-
dc.description.abstractPeritoneal fibrosis is one of the most serious complications of peritoneal dialysis, and is characterized by the activation of peritoneal resident cells (mesothelial cells, endothelial cells, fibroblasts and macrophages), induction of pro-fibrotic peptides, accumulation and deposition of excess matrix proteins within the submesothelium, and vasculopathy of the peritoneal microvasculature. In order to provide novel therapeutic strategies that will allow us to preserve the structural and functional integrity of the peritoneum during peritoneal dialysis, it is essential to elucidate the mechanisms of peritoneal fibrosis. There is now compelling evidence to show that elevated glucose concentrations present in peritoneal dialysis fluids and its by-products play a pivotal role in the initiation of peritoneal fibrosis. This review will describe the pathogenesis of glucose-mediated peritoneal fibrosis, and highlight recent in vitro data that may one day be extended to clinical trials, offering effective treatment in the preservation of the structure of the peritoneum. Such strategies include the employment of alterative osmotic agents (amino acids or icodextrin), transforming growth factor-β1 antagonists, gene therapy, and pharmacological intervention.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins Asia. The Journal's web site is located at http://www.hkjn.org/en_HK
dc.relation.ispartofHong Kong Journal of Nephrologyen_HK
dc.subjectExtracellular matrixen_HK
dc.subjectFibrosisen_HK
dc.subjectGlucoseen_HK
dc.subjectPeritoneal dialysisen_HK
dc.subjectPeritoneumen_HK
dc.subjectTransforming growth factor-β1en_HK
dc.titlePeritoneal fibrosis - Future prevention strategiesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1561-5413&volume=5&spage=8&epage=14&date=2003&atitle=Peritoneal+fibrosis+-+future+prevention+strategiesen_HK
dc.identifier.emailYung, S:ssyyung@hku.hken_HK
dc.identifier.emailChan, TM:dtmchan@hku.hken_HK
dc.identifier.authorityYung, S=rp00455en_HK
dc.identifier.authorityChan, TM=rp00394en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-0842344544en_HK
dc.identifier.hkuros105355en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0842344544&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume5en_HK
dc.identifier.issue1en_HK
dc.identifier.spage8en_HK
dc.identifier.epage14en_HK
dc.publisher.placeHong Kongen_HK
dc.identifier.scopusauthoridYung, S=22636568800en_HK
dc.identifier.scopusauthoridChan, TM=7402687700en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats