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Article: Metabolic and immunologic features of chinese patients with atypical diabetes mellitus

TitleMetabolic and immunologic features of chinese patients with atypical diabetes mellitus
Authors
Issue Date2000
PublisherAmerican Diabetes Association. The Journal's web site is located at http://diabetes.diabetesjournals.org/
Citation
Diabetes Care, 2000, v. 23 n. 3, p. 335-338 How to Cite?
AbstractOBJECTIVE - To determine whether atypical diabetes mellitus (ADM) is present in the Chinese population in Hong Kong. RESEARCH DESIGN AND METHODS - The records of Chinese patients who attended the Diabetes Clinic at Queen Mary Hospital were reviewed. We identified 11 patients who initially presented with acute diabetic ketoacidosis but subsequently displayed clinical features more typical of type 2 diabetes. Metabolic studies and HLA typing were performed to characterize this group of Chinese patients with ADM. RESULTS - C-peptide response of the patients with ADM 1 h after a standard meal was intermediate between that of type 1 diabetic patients (matched for age and duration of diabetes) and that of nondiabetic control subjects (matched for age and BMI) (analysis of variance, P = 0.02). Insulin sensitivity measured by a short insulin tolerance test was not significantly different between patients with ADM and their matched nondiabetic control subjects. HLA typing showed that none of the patients with ADM had the DR3 allele and that the frequency of DR9 was not increased. Only one patient had significantly increased levels of antibodies to GAD and islet cell antigen 512. CONCLUSIONS - ADM, which was first described in African-Americans, is seen also in Chinese subjects. These patients have significant residual C-peptide secretory capacity and should not be misdiagnosed and treated as patients with type 1 diabetes with life-long insulin therapy.
Persistent Identifierhttp://hdl.handle.net/10722/76465
ISSN
2015 Impact Factor: 8.934
2015 SCImago Journal Rankings: 5.827
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTan, KCBen_HK
dc.contributor.authorMackay, IRen_HK
dc.contributor.authorZimmet, PZen_HK
dc.contributor.authorHawkins, BRen_HK
dc.contributor.authorLam, KSLen_HK
dc.date.accessioned2010-09-06T07:21:32Z-
dc.date.available2010-09-06T07:21:32Z-
dc.date.issued2000en_HK
dc.identifier.citationDiabetes Care, 2000, v. 23 n. 3, p. 335-338en_HK
dc.identifier.issn0149-5992en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76465-
dc.description.abstractOBJECTIVE - To determine whether atypical diabetes mellitus (ADM) is present in the Chinese population in Hong Kong. RESEARCH DESIGN AND METHODS - The records of Chinese patients who attended the Diabetes Clinic at Queen Mary Hospital were reviewed. We identified 11 patients who initially presented with acute diabetic ketoacidosis but subsequently displayed clinical features more typical of type 2 diabetes. Metabolic studies and HLA typing were performed to characterize this group of Chinese patients with ADM. RESULTS - C-peptide response of the patients with ADM 1 h after a standard meal was intermediate between that of type 1 diabetic patients (matched for age and duration of diabetes) and that of nondiabetic control subjects (matched for age and BMI) (analysis of variance, P = 0.02). Insulin sensitivity measured by a short insulin tolerance test was not significantly different between patients with ADM and their matched nondiabetic control subjects. HLA typing showed that none of the patients with ADM had the DR3 allele and that the frequency of DR9 was not increased. Only one patient had significantly increased levels of antibodies to GAD and islet cell antigen 512. CONCLUSIONS - ADM, which was first described in African-Americans, is seen also in Chinese subjects. These patients have significant residual C-peptide secretory capacity and should not be misdiagnosed and treated as patients with type 1 diabetes with life-long insulin therapy.en_HK
dc.languageengen_HK
dc.publisherAmerican Diabetes Association. The Journal's web site is located at http://diabetes.diabetesjournals.org/en_HK
dc.relation.ispartofDiabetes Careen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshAnalysis of Varianceen_HK
dc.subject.meshC-Peptide - blooden_HK
dc.subject.meshChina - ethnologyen_HK
dc.subject.meshDiabetes Mellitus - blood - classification - drug therapy - immunologyen_HK
dc.subject.meshDiabetes Mellitus, Type 2 - blood - immunologyen_HK
dc.subject.meshDiabetic Ketoacidosis - blood - immunologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHLA-DR3 Antigen - geneticsen_HK
dc.subject.meshHistocompatibility Testingen_HK
dc.subject.meshHong Kongen_HK
dc.subject.meshHumansen_HK
dc.subject.meshInsulin - therapeutic useen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshRetrospective Studiesen_HK
dc.titleMetabolic and immunologic features of chinese patients with atypical diabetes mellitusen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0149-5992&volume=23&spage=335&epage=338&date=2000&atitle=Metabolic+and+immunologic+features+of+Chinese+patients+with+atypical+diabetes+mellitus.en_HK
dc.identifier.emailTan, KCB:kcbtan@hku.hken_HK
dc.identifier.emailLam, KSL:ksllam@hku.hken_HK
dc.identifier.authorityTan, KCB=rp00402en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid10868861-
dc.identifier.scopuseid_2-s2.0-0034005823en_HK
dc.identifier.hkuros51191en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034005823&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume23en_HK
dc.identifier.issue3en_HK
dc.identifier.spage335en_HK
dc.identifier.epage338en_HK
dc.identifier.isiWOS:000085611100014-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTan, KCB=8082703100en_HK
dc.identifier.scopusauthoridMackay, IR=24923115500en_HK
dc.identifier.scopusauthoridZimmet, PZ=7102179242en_HK
dc.identifier.scopusauthoridHawkins, BR=35944486200en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK

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