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Article: Seroprevalence of Helicobacter pylori in Chinese patients on continuous ambulatory peritoneal dialysis

TitleSeroprevalence of Helicobacter pylori in Chinese patients on continuous ambulatory peritoneal dialysis
Authors
KeywordsChinese
Dyspepsia
Helicobacter pylori
Peritoneal dialysis
Serology
Issue Date2005
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/NEP
Citation
Nephrology, 2005, v. 10 n. 1, p. 21-24 How to Cite?
AbstractBackgrounds and Aims: There is relatively little data on the seroprevalence of Helicobacter pylori in patients undergoing continuous ambulatory peritoneal dialysis (CAPD). This study aims at establishing the seroprevalence of and the factors associated with H. pylori infection in Chinese CARD patients. Methods: All CARD patients from a single dialysis centre were invited to participate in the study. Diagnosis of H. pylori infection was made serologically by the pylori DTect ELISA method. Dyspeptic symptoms were assessed by the Hong Kong Index of Dyspepsia (HKID) Questionnaire. Demographic, clinical and laboratory parameters were correlated with the H. pylori serology results. Results: One hundred and thirty-six Chinese CARD patients were included in the study. The mean age of the patients was 61.8 ± 12.5 years with a male to female ratio of 1:1.4. The mean duration of CARD was 54 ± 42 months. Thirty-five patients (26%) have positive serology against H. pylori. Nineteen patients had a HKID score of >16. There was no association between H. pylori seropositivity and dyspeptic symptoms (P = 0.62). Patients who were seropositive for H. pylori were significantly older (64.9 ± 9.5 years vs 60.7 ± 13.2 years, P < 0.05) and had lower KT/V-values than patients who were seronegative for H. pylori (1.88 ± 0.3 vs 2.03 ± 0.3, P < 0.05). Patients with positive or negative H. pylori serological status did not differ in terms of demographic parameters (e.g. sex, duration of CAPD), clinical factors (e.g. bodyweight, body mass index, hepatitis status, use of H2 antagonists or proton pump inhibitors) and laboratory data (e.g. haemoglobin, serum urea, creatinine, albumin and parathyroid hormone levels). Conclusions: The seroprevalence of H. pylori infection among Chinese CAPD patients is 26%. Helicobacter pylori seropositivity is not associated with dyspepsia. Older age and lower KT/V-values appear to be associated with the development of H. pylori seropositivity in our dialysis population.
Persistent Identifierhttp://hdl.handle.net/10722/76439
ISSN
2015 Impact Factor: 1.796
2015 SCImago Journal Rankings: 0.894
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLui, SLen_HK
dc.contributor.authorWong, WMen_HK
dc.contributor.authorNg, SYen_HK
dc.contributor.authorChan, TMen_HK
dc.contributor.authorLai, KNen_HK
dc.contributor.authorLo, WKen_HK
dc.date.accessioned2010-09-06T07:21:15Z-
dc.date.available2010-09-06T07:21:15Z-
dc.date.issued2005en_HK
dc.identifier.citationNephrology, 2005, v. 10 n. 1, p. 21-24en_HK
dc.identifier.issn1320-5358en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76439-
dc.description.abstractBackgrounds and Aims: There is relatively little data on the seroprevalence of Helicobacter pylori in patients undergoing continuous ambulatory peritoneal dialysis (CAPD). This study aims at establishing the seroprevalence of and the factors associated with H. pylori infection in Chinese CARD patients. Methods: All CARD patients from a single dialysis centre were invited to participate in the study. Diagnosis of H. pylori infection was made serologically by the pylori DTect ELISA method. Dyspeptic symptoms were assessed by the Hong Kong Index of Dyspepsia (HKID) Questionnaire. Demographic, clinical and laboratory parameters were correlated with the H. pylori serology results. Results: One hundred and thirty-six Chinese CARD patients were included in the study. The mean age of the patients was 61.8 ± 12.5 years with a male to female ratio of 1:1.4. The mean duration of CARD was 54 ± 42 months. Thirty-five patients (26%) have positive serology against H. pylori. Nineteen patients had a HKID score of >16. There was no association between H. pylori seropositivity and dyspeptic symptoms (P = 0.62). Patients who were seropositive for H. pylori were significantly older (64.9 ± 9.5 years vs 60.7 ± 13.2 years, P < 0.05) and had lower KT/V-values than patients who were seronegative for H. pylori (1.88 ± 0.3 vs 2.03 ± 0.3, P < 0.05). Patients with positive or negative H. pylori serological status did not differ in terms of demographic parameters (e.g. sex, duration of CAPD), clinical factors (e.g. bodyweight, body mass index, hepatitis status, use of H2 antagonists or proton pump inhibitors) and laboratory data (e.g. haemoglobin, serum urea, creatinine, albumin and parathyroid hormone levels). Conclusions: The seroprevalence of H. pylori infection among Chinese CAPD patients is 26%. Helicobacter pylori seropositivity is not associated with dyspepsia. Older age and lower KT/V-values appear to be associated with the development of H. pylori seropositivity in our dialysis population.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/NEPen_HK
dc.relation.ispartofNephrologyen_HK
dc.subjectChineseen_HK
dc.subjectDyspepsiaen_HK
dc.subjectHelicobacter pylorien_HK
dc.subjectPeritoneal dialysisen_HK
dc.subjectSerologyen_HK
dc.subject.meshAgeden_HK
dc.subject.meshAntibodies, Bacterial - blooden_HK
dc.subject.meshAsian Continental Ancestry Group - statistics & numerical dataen_HK
dc.subject.meshDyspepsia - epidemiologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHelicobacter Infections - epidemiologyen_HK
dc.subject.meshHelicobacter pylori - immunology - isolation & purificationen_HK
dc.subject.meshHong Kong - epidemiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshKidney Failure, Chronic - epidemiology - therapyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPeritoneal Dialysis, Continuous Ambulatory - statistics & numerical dataen_HK
dc.subject.meshSeroepidemiologic Studiesen_HK
dc.titleSeroprevalence of Helicobacter pylori in Chinese patients on continuous ambulatory peritoneal dialysisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1320-5358&volume=10&issue=1&spage=21&epage=24&date=2005&atitle=Seroprevalence+of+Helicobacter+pylori+in+Chinese+patients+on+continuous+ambulatory+peritoneal+dialysisen_HK
dc.identifier.emailChan, TM: dtmchan@hku.hken_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.authorityChan, TM=rp00394en_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1440-1797.2005.00367.xen_HK
dc.identifier.pmid15705177-
dc.identifier.scopuseid_2-s2.0-14844310260en_HK
dc.identifier.hkuros99038en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-14844310260&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume10en_HK
dc.identifier.issue1en_HK
dc.identifier.spage21en_HK
dc.identifier.epage24en_HK
dc.identifier.isiWOS:000226898400005-
dc.publisher.placeAustraliaen_HK
dc.identifier.scopusauthoridLui, SL=7102379130en_HK
dc.identifier.scopusauthoridWong, WM=7403972413en_HK
dc.identifier.scopusauthoridNg, SY=8307036900en_HK
dc.identifier.scopusauthoridChan, TM=7402687700en_HK
dc.identifier.scopusauthoridLai, KN=7402135706en_HK
dc.identifier.scopusauthoridLo, WK=7201502414en_HK
dc.identifier.citeulike92775-

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