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Article: Adefovir dipivoxil for wait-listed and post-liver transplantation patients with lamivudine-resistant hepatitis B: Final long-term results

TitleAdefovir dipivoxil for wait-listed and post-liver transplantation patients with lamivudine-resistant hepatitis B: Final long-term results
Authors
Issue Date2007
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jtoc/106570021
Citation
Liver Transplantation, 2007, v. 13 n. 3, p. 349-360 How to Cite?
AbstractWait-listed (n = 226) or post-liver transplantation (n = 241) chronic hepatitis B (CHB) patients with lamivudine-resistant hepatitis B virus (HBV) were treated with adefovir dipivoxil for a median of 39 and 99 weeks, respectively. Among wait-listed patients, serum HBV DNA levels became undetectable (<l,000 copies/mL) in 59% and 65% at weeks 48 and 96, respectively. After 48 weeks, alanine aminotransferase (ALT), albumin, bilirubin, and prothrombin time normalized in 77%, 76%, 60%, and 84% of wait-listed patients, respectively. Among postransplantation patients, serum HBV DNA levels became undetectable in 40% and 65% at weeks 48 and 96, respectively. After 48 weeks, ALT, albumin, bilirubin, and prothrombin time normalized in 51%, 81%. 76%, and 56% of posttransplantation patients, respectively. Among wait-listed patients who underwent on-study liver transplantation, protection from graft reinfection over a median of 35 weeks was similar among parents who did (n = 34) or did not (n = 23) receive hepatitis B immunoglobulin (HBIg). Hepatitis B surface antigen was detected on the first measurement only in 6% and 9% of patiends who did or did not receive HBIg, respectively. Serum HBV DNA was detected on consecutive visits in 6% and 0% of patients who did or did not receive HBIg, respectively. Treatment-related adverse events led to discontinuation of adefovir dipivoxil in 4% of patients. Cumulative probabilities of resistance were 0%, 2%, and 2% at weeks 48, 96, and 144, respectively. In conclusion, adefovir dipivoxil is effective and safe at wait-listed or posttransplantation CHB patients with lamivudine-resistant HBV and prevents graft reinfection with or without HBIg. © 2007 AASLD.
Persistent Identifierhttp://hdl.handle.net/10722/76418
ISSN
2014 Impact Factor: 4.241
2014 SCImago Journal Rankings: 1.578
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSchiff, Een_HK
dc.contributor.authorLai, CLen_HK
dc.contributor.authorHadziyannis, Sen_HK
dc.contributor.authorNuehaus, Pen_HK
dc.contributor.authorTerrault, Nen_HK
dc.contributor.authorColombo, Men_HK
dc.contributor.authorTillmann, Hen_HK
dc.contributor.authorSamuel, Den_HK
dc.contributor.authorZuezem, Sen_HK
dc.contributor.authorVillenueve, JPen_HK
dc.contributor.authorArteburn, Sen_HK
dc.contributor.authorBorrotoEsoda, Ken_HK
dc.contributor.authorBrosgart, Cen_HK
dc.contributor.authorChuck, Sen_HK
dc.contributor.authorShakil, AOen_HK
dc.contributor.authorFung, Jen_HK
dc.contributor.authorAlberti, Aen_HK
dc.contributor.authorLok, Aen_HK
dc.contributor.authorPicciotto, Aen_HK
dc.contributor.authorTorre, Fen_HK
dc.contributor.authorRiely, Cen_HK
dc.contributor.authorTrepo, Cen_HK
dc.contributor.authorBizollon, Ten_HK
dc.contributor.authorBottaaFridlund, Den_HK
dc.contributor.authorGerolami, Ren_HK
dc.contributor.authorDouglas, Den_HK
dc.contributor.authorRanjan, Den_HK
dc.contributor.authorFaust, Den_HK
dc.contributor.authorTrojan, Jen_HK
dc.contributor.authorGane, Een_HK
dc.contributor.authorVilla, Een_HK
dc.contributor.authorBoarino, Men_HK
dc.contributor.authorSokal, Een_HK
dc.contributor.authorStarkel, Pen_HK
dc.contributor.authorBonino, Fen_HK
dc.contributor.authorMaurizio, Ben_HK
dc.contributor.authorGordon, Fen_HK
dc.contributor.authorPratt, Jen_HK
dc.contributor.authorBerr, Fen_HK
dc.contributor.authorSchiefke, Ien_HK
dc.contributor.authorMcCaughan, Gen_HK
dc.contributor.authorStrasser, Sen_HK
dc.contributor.authorDusheiko, Gen_HK
dc.contributor.authorPageaux, GPen_HK
dc.contributor.authorLarrey, Den_HK
dc.contributor.authorPastore, Gen_HK
dc.contributor.authorSantantonio, Ten_HK
dc.contributor.authorAlexander, Gen_HK
dc.contributor.authorWoodall, Ten_HK
dc.contributor.authorVan Vlierberghe, Hen_HK
dc.contributor.authorColle, Ien_HK
dc.contributor.authorHarley, Hen_HK
dc.contributor.authorGuggenheim, Jen_HK
dc.contributor.authorMyxStaccini, Aen_HK
dc.contributor.authorMetreau, JMen_HK
dc.contributor.authorMavier, Pen_HK
dc.contributor.authorVierling, Jen_HK
dc.contributor.authorTran, Ten_HK
dc.contributor.authorGirgrah, Nen_HK
dc.contributor.authorNyberg, Len_HK
dc.contributor.authorYuen, MFen_HK
dc.contributor.authorMa, Men_HK
dc.contributor.authorBalnco, MDen_HK
dc.contributor.authorMerli, Men_HK
dc.contributor.authorTanzilli, Pen_HK
dc.contributor.authorAngelico, Men_HK
dc.contributor.authorDi Paolo, Den_HK
dc.contributor.authorRizzetto, Men_HK
dc.contributor.authorMarzano, Aen_HK
dc.contributor.authorLampertico, Pen_HK
dc.contributor.authorPrieto, Men_HK
dc.contributor.authorBerenguer, Men_HK
dc.contributor.authorFelder, Men_HK
dc.contributor.authorSterneck, Men_HK
dc.contributor.authorWillems, Men_HK
dc.contributor.authorCharlton, Men_HK
dc.contributor.authorGunneson, Ten_HK
dc.contributor.authorRitter, Men_HK
dc.contributor.authorVoight, Men_HK
dc.contributor.authorSwift, Jen_HK
dc.contributor.authorShiffman, Men_HK
dc.contributor.authorTassopoulos, Nen_HK
dc.contributor.authorKlissas, Ien_HK
dc.contributor.authorNaourmov, Nen_HK
dc.contributor.authorChamouard, Pen_HK
dc.contributor.authorMarcellin, Pen_HK
dc.contributor.authorDurand, Fen_HK
dc.contributor.authorAngus, Pen_HK
dc.contributor.authorNathan, Cen_HK
dc.contributor.authorToniutto, Pen_HK
dc.contributor.authorFumo, Een_HK
dc.contributor.authorAndreone, Pen_HK
dc.contributor.authorCursaro, Cen_HK
dc.contributor.authorBarcena, Ren_HK
dc.contributor.authorHoz, FGen_HK
dc.contributor.authorZachoval, Ren_HK
dc.contributor.authorChristina, Men_HK
dc.contributor.authorDe Man, RAen_HK
dc.contributor.authorMetselaar, Hen_HK
dc.date.accessioned2010-09-06T07:21:01Z-
dc.date.available2010-09-06T07:21:01Z-
dc.date.issued2007en_HK
dc.identifier.citationLiver Transplantation, 2007, v. 13 n. 3, p. 349-360en_HK
dc.identifier.issn1527-6465en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76418-
dc.description.abstractWait-listed (n = 226) or post-liver transplantation (n = 241) chronic hepatitis B (CHB) patients with lamivudine-resistant hepatitis B virus (HBV) were treated with adefovir dipivoxil for a median of 39 and 99 weeks, respectively. Among wait-listed patients, serum HBV DNA levels became undetectable (<l,000 copies/mL) in 59% and 65% at weeks 48 and 96, respectively. After 48 weeks, alanine aminotransferase (ALT), albumin, bilirubin, and prothrombin time normalized in 77%, 76%, 60%, and 84% of wait-listed patients, respectively. Among postransplantation patients, serum HBV DNA levels became undetectable in 40% and 65% at weeks 48 and 96, respectively. After 48 weeks, ALT, albumin, bilirubin, and prothrombin time normalized in 51%, 81%. 76%, and 56% of posttransplantation patients, respectively. Among wait-listed patients who underwent on-study liver transplantation, protection from graft reinfection over a median of 35 weeks was similar among parents who did (n = 34) or did not (n = 23) receive hepatitis B immunoglobulin (HBIg). Hepatitis B surface antigen was detected on the first measurement only in 6% and 9% of patiends who did or did not receive HBIg, respectively. Serum HBV DNA was detected on consecutive visits in 6% and 0% of patients who did or did not receive HBIg, respectively. Treatment-related adverse events led to discontinuation of adefovir dipivoxil in 4% of patients. Cumulative probabilities of resistance were 0%, 2%, and 2% at weeks 48, 96, and 144, respectively. In conclusion, adefovir dipivoxil is effective and safe at wait-listed or posttransplantation CHB patients with lamivudine-resistant HBV and prevents graft reinfection with or without HBIg. © 2007 AASLD.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jtoc/106570021en_HK
dc.relation.ispartofLiver Transplantationen_HK
dc.rightsLiver Transplantation. Copyright © John Wiley & Sons, Inc.en_HK
dc.subject.meshAdenine - adverse effects - analogs & derivatives - therapeutic useen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAntiviral Agents - adverse effects - therapeutic useen_HK
dc.subject.meshDNA, Viral - blooden_HK
dc.subject.meshDrug Resistance, Viralen_HK
dc.subject.meshDrug Therapy, Combinationen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHepatitis B - blood - drug therapy - prevention & controlen_HK
dc.subject.meshHepatitis B virus - geneticsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshKidney Diseases - chemically induceden_HK
dc.subject.meshLamivudine - adverse effects - therapeutic useen_HK
dc.subject.meshLiver Transplantation - adverse effects - methodsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPhosphonic Acids - adverse effects - therapeutic useen_HK
dc.subject.meshProspective Studiesen_HK
dc.subject.meshRecurrence - prevention & controlen_HK
dc.subject.meshWaiting Listsen_HK
dc.titleAdefovir dipivoxil for wait-listed and post-liver transplantation patients with lamivudine-resistant hepatitis B: Final long-term resultsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1527-6465&volume=13&spage=349&epage=360&date=2007&atitle=Adefovir+dipivoxil+for+wait-listed+and+post-liver+transplantation+patients+with+lamivudine-resistant+hepatitis+B:+final+long-term+results.en_HK
dc.identifier.emailLai, CL:hrmelcl@hku.hken_HK
dc.identifier.emailYuen, MF:mfyuen@hkucc.hku.hken_HK
dc.identifier.authorityLai, CL=rp00314en_HK
dc.identifier.authorityYuen, MF=rp00479en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/lt.20981en_HK
dc.identifier.pmid17326221en_HK
dc.identifier.scopuseid_2-s2.0-33947427581en_HK
dc.identifier.hkuros131794en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33947427581&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume13en_HK
dc.identifier.issue3en_HK
dc.identifier.spage349en_HK
dc.identifier.epage360en_HK
dc.identifier.isiWOS:000244609200008-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridSchiff, E=7102846957en_HK
dc.identifier.scopusauthoridLai, CL=7403086396en_HK
dc.identifier.scopusauthoridHadziyannis, S=35376058400en_HK
dc.identifier.scopusauthoridNuehaus, P=16053207500en_HK
dc.identifier.scopusauthoridTerrault, N=7003781035en_HK
dc.identifier.scopusauthoridColombo, M=7203013850en_HK
dc.identifier.scopusauthoridTillmann, H=7006688680en_HK
dc.identifier.scopusauthoridSamuel, D=7102275307en_HK
dc.identifier.scopusauthoridZuezem, S=16053713000en_HK
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dc.identifier.scopusauthoridArteburn, S=16051941800en_HK
dc.identifier.scopusauthoridBorrotoEsoda, K=6602315755en_HK
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dc.identifier.scopusauthoridShakil, AO=15521195200en_HK
dc.identifier.scopusauthoridFung, J=35398340400en_HK
dc.identifier.scopusauthoridAlberti, A=35379148100en_HK
dc.identifier.scopusauthoridLok, A=35379868500en_HK
dc.identifier.scopusauthoridPicciotto, A=7007012299en_HK
dc.identifier.scopusauthoridTorre, F=7005311702en_HK
dc.identifier.scopusauthoridRiely, C=7006713344en_HK
dc.identifier.scopusauthoridTrepo, C=35373652400en_HK
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dc.identifier.scopusauthoridDe Man, RA=7006113112en_HK
dc.identifier.scopusauthoridMetselaar, H=7006441306en_HK

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