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Article: Primary aldosteronism: Results of surgical treatment

TitlePrimary aldosteronism: Results of surgical treatment
Authors
Issue Date1996
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.annalsofsurgery.com
Citation
Annals Of Surgery, 1996, v. 224 n. 2, p. 125-130 How to Cite?
AbstractSummary Background Data: Management of primary hyperaldosteronism has undergone dramatic changes in the past 40 years. This retrospective study was carried out to review our recent surgical experience and to identify potential factors associated with postoperative persistent hypertension. Methods: Forty six patients who had adrenal surgery for primary hyperaldosteronism from 1983 to 1994 were included in the study. Results: Periodic paralysis occurred in 12 (26%) patients. Hypertension and hypokalemia (mean serum potassium, 2.2 + 0.5 [+ standard deviation {SD} mmol/L) were present in all patients. Postural study was diagnostic in 85% (23 of 27). Computed tomography scan correctly localized the tumor in all except 1 patient, and venous sampling was performed in 11 patients. There was no operative mortality, and complications developed in six patients (13%), including one patient requiring reexploration for hemostasis. All patients had a histologically documented adenoma. During a mean follow up of 51 months, 34 (77%) of the 44 patients required no further antihypertensive treatment. Two patients were lost to follow-up. Age, response to spironolactone treatment, and blood pressure on discharge were risk factors identified for persistent hypertension. Conclusion: Primary hyperaldosteronism due to aldosterone-producing adenoma can be diagnosed and localized expeditiously, whereas surgical treatment can be performed safely. Hypokalemia may be cured by surgical treatment, although persistent hypertension, usually of a mild degree, still occurs in selected patients.
Persistent Identifierhttp://hdl.handle.net/10722/76392
ISSN
2015 Impact Factor: 8.569
2015 SCImago Journal Rankings: 4.503
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLo, CYen_HK
dc.contributor.authorTam, PCen_HK
dc.contributor.authorKung, AWCen_HK
dc.contributor.authorLam, KSLen_HK
dc.contributor.authorWong, Jen_HK
dc.date.accessioned2010-09-06T07:20:44Z-
dc.date.available2010-09-06T07:20:44Z-
dc.date.issued1996en_HK
dc.identifier.citationAnnals Of Surgery, 1996, v. 224 n. 2, p. 125-130en_HK
dc.identifier.issn0003-4932en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76392-
dc.description.abstractSummary Background Data: Management of primary hyperaldosteronism has undergone dramatic changes in the past 40 years. This retrospective study was carried out to review our recent surgical experience and to identify potential factors associated with postoperative persistent hypertension. Methods: Forty six patients who had adrenal surgery for primary hyperaldosteronism from 1983 to 1994 were included in the study. Results: Periodic paralysis occurred in 12 (26%) patients. Hypertension and hypokalemia (mean serum potassium, 2.2 + 0.5 [+ standard deviation {SD} mmol/L) were present in all patients. Postural study was diagnostic in 85% (23 of 27). Computed tomography scan correctly localized the tumor in all except 1 patient, and venous sampling was performed in 11 patients. There was no operative mortality, and complications developed in six patients (13%), including one patient requiring reexploration for hemostasis. All patients had a histologically documented adenoma. During a mean follow up of 51 months, 34 (77%) of the 44 patients required no further antihypertensive treatment. Two patients were lost to follow-up. Age, response to spironolactone treatment, and blood pressure on discharge were risk factors identified for persistent hypertension. Conclusion: Primary hyperaldosteronism due to aldosterone-producing adenoma can be diagnosed and localized expeditiously, whereas surgical treatment can be performed safely. Hypokalemia may be cured by surgical treatment, although persistent hypertension, usually of a mild degree, still occurs in selected patients.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.annalsofsurgery.comen_HK
dc.relation.ispartofAnnals of Surgeryen_HK
dc.rightsAnnals of Surgery. Copyright © Lippincott Williams & Wilkins.en_HK
dc.subject.meshAdrenalectomy - adverse effectsen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFollow-Up Studiesen_HK
dc.subject.meshHumansen_HK
dc.subject.meshHyperaldosteronism - diagnosis - surgeryen_HK
dc.subject.meshHypertension - epidemiology - etiologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPostoperative Complications - epidemiology - etiologyen_HK
dc.subject.meshPreoperative Careen_HK
dc.subject.meshRetrospective Studiesen_HK
dc.subject.meshRisk Factorsen_HK
dc.titlePrimary aldosteronism: Results of surgical treatmenten_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0003-4932&volume=224&spage=125&epage=130&date=1996&atitle=Primary+Aldosteronism:+Results+of+Surgical+Treatmenten_HK
dc.identifier.emailKung, AWC: awckung@hku.hken_HK
dc.identifier.emailLam, KSL: ksllam@hku.hken_HK
dc.identifier.emailWong, J: jwong@hkucc.hku.hken_HK
dc.identifier.authorityKung, AWC=rp00368en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.identifier.authorityWong, J=rp00322en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/00000658-199608000-00003en_HK
dc.identifier.pmid8757374-
dc.identifier.scopuseid_2-s2.0-9444291913en_HK
dc.identifier.hkuros22844en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-9444291913&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume224en_HK
dc.identifier.issue2en_HK
dc.identifier.spage125en_HK
dc.identifier.epage130en_HK
dc.identifier.isiWOS:A1996VC53900003-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLo, CY=16417392800en_HK
dc.identifier.scopusauthoridTam, PC=7202539419en_HK
dc.identifier.scopusauthoridKung, AWC=7102322339en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK
dc.identifier.scopusauthoridWong, J=8049324500en_HK

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