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Article: Papillary carcinoma of thyroid: A 30-yr clinicopathological review of the histological variants

TitlePapillary carcinoma of thyroid: A 30-yr clinicopathological review of the histological variants
Authors
Issue Date2005
PublisherHumana Press, Inc.
Citation
Endocrine Pathology, 2005, v. 16 n. 4, p. 323-330 How to Cite?
AbstractMany histological variants of PTC have been described and some are known to have prognostic significance. However, their relative frequencies and associated clinicopathological features in a large cohort of patients with PTC treated at a single institution have seldom been documented. We reclassified 1035 malignant thyroid tumors treated in a 30-yr study period, into variants of PTC according to current histological criteria and analyzed their features. Six hundred and fifty two patients (153 men; 499 women) with PTC were identified. PTC accounted for 72.8% of primary thyroid cancers. Conventional papillary carcinoma (n = 300) accounted for 46% of PTC and papillary microcarcinoma 27.8% (n = 181). The frequencies of the common histological variants were follicular (17.6%, n = 115), tall cell (4%, n = 26), and diffuse sclerosing (1.8%, n = 12). Uncommon histological variants including solid (n = 5), diffuse follicular (n = 5), papillary carcinoma with focal insular component (n = 3), columnar cell (n = 2), papillary carcinoma with fasciitis-like stroma (n = 2), and oncocytic (n = 1) were also noted. Histological variants of PTC had different age presentation, tumor size, frequencies of lymph node metastases, calcification, metaplastic bone, and psammoma bodies, when compared with conventional PTC. We conclude that a high prevalence of different variants of PTC with distinct clinicopathological features can be documented. Recognition of these histological variants may be important for better management of patients with PTC. © Copyright 2005 by Humana Press Inc. All rights of any nature whatsoever reserved.
Persistent Identifierhttp://hdl.handle.net/10722/76390
ISSN
2015 Impact Factor: 1.817
2015 SCImago Journal Rankings: 0.488
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLam, AKYen_HK
dc.contributor.authorLo, CYen_HK
dc.contributor.authorLam, KSLen_HK
dc.date.accessioned2010-09-06T07:20:43Z-
dc.date.available2010-09-06T07:20:43Z-
dc.date.issued2005en_HK
dc.identifier.citationEndocrine Pathology, 2005, v. 16 n. 4, p. 323-330en_HK
dc.identifier.issn1046-3976en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76390-
dc.description.abstractMany histological variants of PTC have been described and some are known to have prognostic significance. However, their relative frequencies and associated clinicopathological features in a large cohort of patients with PTC treated at a single institution have seldom been documented. We reclassified 1035 malignant thyroid tumors treated in a 30-yr study period, into variants of PTC according to current histological criteria and analyzed their features. Six hundred and fifty two patients (153 men; 499 women) with PTC were identified. PTC accounted for 72.8% of primary thyroid cancers. Conventional papillary carcinoma (n = 300) accounted for 46% of PTC and papillary microcarcinoma 27.8% (n = 181). The frequencies of the common histological variants were follicular (17.6%, n = 115), tall cell (4%, n = 26), and diffuse sclerosing (1.8%, n = 12). Uncommon histological variants including solid (n = 5), diffuse follicular (n = 5), papillary carcinoma with focal insular component (n = 3), columnar cell (n = 2), papillary carcinoma with fasciitis-like stroma (n = 2), and oncocytic (n = 1) were also noted. Histological variants of PTC had different age presentation, tumor size, frequencies of lymph node metastases, calcification, metaplastic bone, and psammoma bodies, when compared with conventional PTC. We conclude that a high prevalence of different variants of PTC with distinct clinicopathological features can be documented. Recognition of these histological variants may be important for better management of patients with PTC. © Copyright 2005 by Humana Press Inc. All rights of any nature whatsoever reserved.en_HK
dc.languageengen_HK
dc.publisherHumana Press, Inc.en_HK
dc.relation.ispartofEndocrine Pathologyen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshCarcinoma, Papillary - pathologyen_HK
dc.subject.meshChilden_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshSex Factorsen_HK
dc.subject.meshThyroid Neoplasms - pathologyen_HK
dc.titlePapillary carcinoma of thyroid: A 30-yr clinicopathological review of the histological variantsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1046-3976&volume=16&issue=4&spage=323&epage=330&date=2005&atitle=Papillary+carcinoma+of+thyroid:+A+30-yr+clinicopathological+review+of+the+histological+variantsen_HK
dc.identifier.emailLam, KSL:ksllam@hku.hken_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1385/EP:16:4:323en_HK
dc.identifier.pmid16627919-
dc.identifier.scopuseid_2-s2.0-33646684498en_HK
dc.identifier.hkuros117935en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33646684498&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume16en_HK
dc.identifier.issue4en_HK
dc.identifier.spage323en_HK
dc.identifier.epage330en_HK
dc.identifier.isiWOS:000235963500006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLam, AKY=7403657165en_HK
dc.identifier.scopusauthoridLo, CY=16417392800en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK

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