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Article: Hepatic expression of hepatitis B virus genome in chronic hepatitis B virus infection

TitleHepatic expression of hepatitis B virus genome in chronic hepatitis B virus infection
Authors
Issue Date1996
PublisherAmerican Society for Clinical Pathology. The Journal's web site is located at http://www.ajcp.com
Citation
American Journal Of Clinical Pathology, 1996, v. 105 n. 1, p. 87-95 How to Cite?
AbstractThe expression of hepatitis B virus (HBV) DNA in the liver was studied by nonisotopic in situ hybridization and correlated with liver histology, different phases in the natural evolution of chronic hepatitis B, and hepatic expression of HBV antigens in 251 Chinese patients with chronic HBV infection. A good correlation was found between the detection of HBV-DNA by in situ hybridization and serum HBV-DNA (P <.01). Chronic active hepatitis had the highest HBV-DNA detected in cytoplasm and nuclei, compared with livers showing minimal change, chronic persistent hepatitis, cirrhosis, and hepatocellular carcinoma. HBV-DNA in cytoplasm exceeded HBV-DNA in nucleus in all patients except in livers with hepatocellular carcinoma. Hepatic HBV-DNA correlated with disease activity (P <.02) and the correlation was highly significant with intralobular activity (P <.001). Patients in the early viral replicative phase of infection had higher levels of cytoplasmic and nuclear HBV-DNA compared with the late viral nonreplicative phase. Cytoplasmic and nuclear HBV-DNA correlated with hepatic expression of HBcAg and HBsAg (P <.05 in both cases), but not with HBeAg. These data indicate that hepatic expression of HBV-DNA follows the natural history of chronic HBV infection and is associated with active liver disease.
Persistent Identifierhttp://hdl.handle.net/10722/76374
ISSN
2015 Impact Factor: 2.278
2015 SCImago Journal Rankings: 1.129
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWu, PCen_HK
dc.contributor.authorFang, JWSen_HK
dc.contributor.authorLai, CLen_HK
dc.contributor.authorLau, SSKHen_HK
dc.contributor.authorLo, CKen_HK
dc.contributor.authorLai, Aen_HK
dc.contributor.authorLau, JYNen_HK
dc.date.accessioned2010-09-06T07:20:33Z-
dc.date.available2010-09-06T07:20:33Z-
dc.date.issued1996en_HK
dc.identifier.citationAmerican Journal Of Clinical Pathology, 1996, v. 105 n. 1, p. 87-95en_HK
dc.identifier.issn0002-9173en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76374-
dc.description.abstractThe expression of hepatitis B virus (HBV) DNA in the liver was studied by nonisotopic in situ hybridization and correlated with liver histology, different phases in the natural evolution of chronic hepatitis B, and hepatic expression of HBV antigens in 251 Chinese patients with chronic HBV infection. A good correlation was found between the detection of HBV-DNA by in situ hybridization and serum HBV-DNA (P <.01). Chronic active hepatitis had the highest HBV-DNA detected in cytoplasm and nuclei, compared with livers showing minimal change, chronic persistent hepatitis, cirrhosis, and hepatocellular carcinoma. HBV-DNA in cytoplasm exceeded HBV-DNA in nucleus in all patients except in livers with hepatocellular carcinoma. Hepatic HBV-DNA correlated with disease activity (P <.02) and the correlation was highly significant with intralobular activity (P <.001). Patients in the early viral replicative phase of infection had higher levels of cytoplasmic and nuclear HBV-DNA compared with the late viral nonreplicative phase. Cytoplasmic and nuclear HBV-DNA correlated with hepatic expression of HBcAg and HBsAg (P <.05 in both cases), but not with HBeAg. These data indicate that hepatic expression of HBV-DNA follows the natural history of chronic HBV infection and is associated with active liver disease.en_HK
dc.languageengen_HK
dc.publisherAmerican Society for Clinical Pathology. The Journal's web site is located at http://www.ajcp.comen_HK
dc.relation.ispartofAmerican Journal of Clinical Pathologyen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshCell Nucleus - virologyen_HK
dc.subject.meshCytoplasm - virologyen_HK
dc.subject.meshDNA, Viral - analysisen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGenome, Viralen_HK
dc.subject.meshHepatitis B - pathology - virologyen_HK
dc.subject.meshHepatitis B virus - genetics - physiologyen_HK
dc.subject.meshHepatitis, Chronic - pathology - virologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshIn Situ Hybridizationen_HK
dc.subject.meshLiver - pathology - virologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshVirus Replicationen_HK
dc.titleHepatic expression of hepatitis B virus genome in chronic hepatitis B virus infectionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0002-9173&volume=105&spage=87&epage=95&date=1996&atitle=Hepatic+expression+of+hepatitis+B+virus+genome+in+chronic+hepatitis+B+virus+infectionen_HK
dc.identifier.emailLai, CL:hrmelcl@hku.hken_HK
dc.identifier.authorityLai, CL=rp00314en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid8561093-
dc.identifier.scopuseid_2-s2.0-0030062968en_HK
dc.identifier.hkuros13562en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030062968&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume105en_HK
dc.identifier.issue1en_HK
dc.identifier.spage87en_HK
dc.identifier.epage95en_HK
dc.identifier.isiWOS:A1996TQ29000014-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWu, PC=7403119323en_HK
dc.identifier.scopusauthoridFang, JWS=7402963750en_HK
dc.identifier.scopusauthoridLai, CL=7403086396en_HK
dc.identifier.scopusauthoridLau, SSKH=55239453800en_HK
dc.identifier.scopusauthoridLo, CK=16413500600en_HK
dc.identifier.scopusauthoridLai, A=36769814300en_HK
dc.identifier.scopusauthoridLau, JYN=7402446047en_HK

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