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Article: Natural history of hepatitis-related hepatocellular carcinoma

TitleNatural history of hepatitis-related hepatocellular carcinoma
Authors
KeywordsHepatitis
Hepatocellular carcinoma
Natural history
Issue Date2008
PublisherBaishideng Publishing Group. The Journal's web site is located at http://www.wjgnet.com/1007-9327/index.htm
Citation
World Journal Of Gastroenterology, 2008, v. 14 n. 11, p. 1652-1656 How to Cite?
AbstractHepatocellular carcinoma (HCC) is an important cause of cancer death in the world. It has great regional differences in the pathology and epidemiology. The variation is greatly influenced by the aetiologies of the disease. Hepatitis B and C infection are the most important risk factors. HCC incidence rates are higher but in decreasing trend in developing countries. However, the figures in the developed countries are contrary. Successful hepatitis B virus (HBV) vaccination programs, better food hygiene, increased global hepatitis C virus (HCV) prevalence and population migration are the possible explanations. A number of clinical and pathogenic differences exist between HBV- and HCV-related HCC. HBV infection leads to the development of HCC through direct and indirect pathways as it has the ability to integrate into the host genome affecting cellular signaling and growth control. HCV causes HCC mainly through indirect pathways: chronic inflammation, cell deaths and proliferation. As a result, HCC is almost exclusively found in cirrhotic HCV patients while HCC is sometimes found in HBV patients without significant liver cirrhosis. Due to the different severities of liver cirrhosis and HCC extent, therapeutic strategies from resection, liver transplantation to symptoms palliation are available. Poorly differentiated histology, lack of fibrous capsule, large tumour size, early vascular invasion and elevated serum levels of alpha fetoprotein (AFP) are the features for more aggressive disease. Combined with markers of liver reserve and performance status, accurate scoring systems and models have been developed to predict patients' survival and match best treatment option. © 2008 WJG. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/76369
ISSN
2023 Impact Factor: 4.3
2023 SCImago Journal Rankings: 1.063
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBut, DYKen_HK
dc.contributor.authorLai, CLen_HK
dc.contributor.authorYuen, MFen_HK
dc.date.accessioned2010-09-06T07:20:30Z-
dc.date.available2010-09-06T07:20:30Z-
dc.date.issued2008en_HK
dc.identifier.citationWorld Journal Of Gastroenterology, 2008, v. 14 n. 11, p. 1652-1656en_HK
dc.identifier.issn1007-9327en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76369-
dc.description.abstractHepatocellular carcinoma (HCC) is an important cause of cancer death in the world. It has great regional differences in the pathology and epidemiology. The variation is greatly influenced by the aetiologies of the disease. Hepatitis B and C infection are the most important risk factors. HCC incidence rates are higher but in decreasing trend in developing countries. However, the figures in the developed countries are contrary. Successful hepatitis B virus (HBV) vaccination programs, better food hygiene, increased global hepatitis C virus (HCV) prevalence and population migration are the possible explanations. A number of clinical and pathogenic differences exist between HBV- and HCV-related HCC. HBV infection leads to the development of HCC through direct and indirect pathways as it has the ability to integrate into the host genome affecting cellular signaling and growth control. HCV causes HCC mainly through indirect pathways: chronic inflammation, cell deaths and proliferation. As a result, HCC is almost exclusively found in cirrhotic HCV patients while HCC is sometimes found in HBV patients without significant liver cirrhosis. Due to the different severities of liver cirrhosis and HCC extent, therapeutic strategies from resection, liver transplantation to symptoms palliation are available. Poorly differentiated histology, lack of fibrous capsule, large tumour size, early vascular invasion and elevated serum levels of alpha fetoprotein (AFP) are the features for more aggressive disease. Combined with markers of liver reserve and performance status, accurate scoring systems and models have been developed to predict patients' survival and match best treatment option. © 2008 WJG. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherBaishideng Publishing Group. The Journal's web site is located at http://www.wjgnet.com/1007-9327/index.htmen_HK
dc.relation.ispartofWorld Journal of Gastroenterologyen_HK
dc.subjectHepatitis-
dc.subjectHepatocellular carcinoma-
dc.subjectNatural history-
dc.subject.meshCarcinoma, Hepatocellular - mortality - prevention & control - therapy - virologyen_HK
dc.subject.meshDisease Progressionen_HK
dc.subject.meshHepatitis B - complications - mortality - prevention & controlen_HK
dc.subject.meshHepatitis B Vaccinesen_HK
dc.subject.meshHepatitis C - complications - mortality - prevention & controlen_HK
dc.subject.meshHumansen_HK
dc.subject.meshIncidenceen_HK
dc.subject.meshLiver Neoplasms - mortality - prevention & control - therapy - virologyen_HK
dc.subject.meshPrognosisen_HK
dc.subject.meshRisk Factorsen_HK
dc.subject.meshTreatment Outcomeen_HK
dc.titleNatural history of hepatitis-related hepatocellular carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1007-9327&volume=14&spage=1652&epage=6&date=2008&atitle=Natural+history+of+hepatitis-related+hepatocellular+carcinomaen_HK
dc.identifier.emailLai, CL:hrmelcl@hku.hken_HK
dc.identifier.emailYuen, MF:mfyuen@hkucc.hku.hken_HK
dc.identifier.authorityLai, CL=rp00314en_HK
dc.identifier.authorityYuen, MF=rp00479en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3748/wjg.14.1652en_HK
dc.identifier.pmid18350595-
dc.identifier.pmcidPMC2695904-
dc.identifier.scopuseid_2-s2.0-41849131802en_HK
dc.identifier.hkuros149195en_HK
dc.identifier.hkuros149089-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-41849131802&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume14en_HK
dc.identifier.issue11en_HK
dc.identifier.spage1652en_HK
dc.identifier.epage1656en_HK
dc.identifier.isiWOS:000255718500004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridBut, DYK=24343113400en_HK
dc.identifier.scopusauthoridLai, CL=7403086396en_HK
dc.identifier.scopusauthoridYuen, MF=7102031955en_HK
dc.identifier.issnl1007-9327-

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