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Article: Detection and clinical features of hepatitis C virus type 6 infections in blood donors from Hong Kong

TitleDetection and clinical features of hepatitis C virus type 6 infections in blood donors from Hong Kong
Authors
Issue Date1996
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/32763
Citation
Journal Of Medical Virology, 1996, v. 50 n. 2, p. 168-175 How to Cite?
AbstractThe genotype distribution of hepatitis C virus (HCV) was investigated in 212 viraemic blood donors from Hong Kong. A subset of the samples was investigated using three different genotyping assays to establish the accuracy of each in this population. These assays were restriction fragment length polymorphism (RFLP) of amplified 5' noncoding region (5'NCR) sequences, RFLP of the core region, and a serotyping assay using peptides from two antigenic regions of NS4. Genotypes detected in Hong Kong blood donors were 1a (6.2%), 1b (58.8%), 2a (1.4%), 2b (1.4%), 3a (1.9%), and 6a (27.0%). All genotyping assays produced concordant results. No evidence was obtained for the presence of type 6 group variants recently identified in Southeast Asia, other than type 6a. A serotyping assay based upon the detection of type-specific antibody to epitopes in NS4 produced similar results to the genotyping assays (98% concordance), but a reduced sensitivity (75%) compared with genotyping methods. Sequence variation in NS4 was not the cause of the reduced rate of detection of type 6 antibody in this population. Eighty-four percent donors infected with type 6a were male, compared to 75% donors infected with type 1b. The median alanine transaminase (ALT) level in type 6 infected donors was lower than in type 1b, (43.8 and 51.1 U/l, respectively) although these values were not statistically significant (P = 0.094). There was no significant difference between the ages of donors infected with types 1b and 6a. Risk factors for HCV infection in the blood donors included blood transfusion, intravenous drug abuse, and tattooing. A significantly greater number of donors infected with HCV-6a reported a history of drug abuse (66%) than donors infected with HCV-1b (7%).
Persistent Identifierhttp://hdl.handle.net/10722/76314
ISSN
2015 Impact Factor: 1.998
2015 SCImago Journal Rankings: 1.015
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPrescott, LEen_HK
dc.contributor.authorSimmonds, Pen_HK
dc.contributor.authorLai, CLen_HK
dc.contributor.authorChan, NKen_HK
dc.contributor.authorPike, Ien_HK
dc.contributor.authorYap, PLen_HK
dc.contributor.authorLin, CKen_HK
dc.date.accessioned2010-09-06T07:19:55Z-
dc.date.available2010-09-06T07:19:55Z-
dc.date.issued1996en_HK
dc.identifier.citationJournal Of Medical Virology, 1996, v. 50 n. 2, p. 168-175en_HK
dc.identifier.issn0146-6615en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76314-
dc.description.abstractThe genotype distribution of hepatitis C virus (HCV) was investigated in 212 viraemic blood donors from Hong Kong. A subset of the samples was investigated using three different genotyping assays to establish the accuracy of each in this population. These assays were restriction fragment length polymorphism (RFLP) of amplified 5' noncoding region (5'NCR) sequences, RFLP of the core region, and a serotyping assay using peptides from two antigenic regions of NS4. Genotypes detected in Hong Kong blood donors were 1a (6.2%), 1b (58.8%), 2a (1.4%), 2b (1.4%), 3a (1.9%), and 6a (27.0%). All genotyping assays produced concordant results. No evidence was obtained for the presence of type 6 group variants recently identified in Southeast Asia, other than type 6a. A serotyping assay based upon the detection of type-specific antibody to epitopes in NS4 produced similar results to the genotyping assays (98% concordance), but a reduced sensitivity (75%) compared with genotyping methods. Sequence variation in NS4 was not the cause of the reduced rate of detection of type 6 antibody in this population. Eighty-four percent donors infected with type 6a were male, compared to 75% donors infected with type 1b. The median alanine transaminase (ALT) level in type 6 infected donors was lower than in type 1b, (43.8 and 51.1 U/l, respectively) although these values were not statistically significant (P = 0.094). There was no significant difference between the ages of donors infected with types 1b and 6a. Risk factors for HCV infection in the blood donors included blood transfusion, intravenous drug abuse, and tattooing. A significantly greater number of donors infected with HCV-6a reported a history of drug abuse (66%) than donors infected with HCV-1b (7%).en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/32763en_HK
dc.relation.ispartofJournal of Medical Virologyen_HK
dc.rightsJournal of Medical Virology. Copyright © John Wiley & Sons, Inc.en_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshAmino Acid Sequenceen_HK
dc.subject.meshBlood Donorsen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGenotypeen_HK
dc.subject.meshHepacivirus - classification - genetics - immunology - isolation & purificationen_HK
dc.subject.meshHepatitis C - blood - epidemiology - immunology - virologyen_HK
dc.subject.meshHong Kong - epidemiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshMolecular Sequence Dataen_HK
dc.subject.meshPhylogenyen_HK
dc.subject.meshPolymerase Chain Reactionen_HK
dc.subject.meshPolymorphism, Restriction Fragment Lengthen_HK
dc.subject.meshRNA, Viral - analysisen_HK
dc.subject.meshReagent Kits, Diagnosticen_HK
dc.subject.meshRestriction Mappingen_HK
dc.subject.meshSequence Homology, Amino Aciden_HK
dc.subject.meshViral Core Proteins - genetics - immunologyen_HK
dc.subject.meshViral Nonstructural Proteins - genetics - immunologyen_HK
dc.titleDetection and clinical features of hepatitis C virus type 6 infections in blood donors from Hong Kongen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0146-6615&volume=50&spage=168&epage=175&date=1996&atitle=Detection+and+clinical+features+of+hepatitis+C+virus+type+6+infections+in+blood+donors+from+Hong+Kongen_HK
dc.identifier.emailLai, CL:hrmelcl@hku.hken_HK
dc.identifier.authorityLai, CL=rp00314en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/(SICI)1096-9071(199610)50:2<168::AID-JMV10>3.0.CO;2-Ien_HK
dc.identifier.pmid8915883-
dc.identifier.scopuseid_2-s2.0-0029862049en_HK
dc.identifier.hkuros22910en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0029862049&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume50en_HK
dc.identifier.issue2en_HK
dc.identifier.spage168en_HK
dc.identifier.epage175en_HK
dc.identifier.isiWOS:A1996VQ56700010-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridPrescott, LE=15071124500en_HK
dc.identifier.scopusauthoridSimmonds, P=7102203090en_HK
dc.identifier.scopusauthoridLai, CL=7403086396en_HK
dc.identifier.scopusauthoridChan, NK=7101677541en_HK
dc.identifier.scopusauthoridPike, I=55254320100en_HK
dc.identifier.scopusauthoridYap, PL=16938057500en_HK
dc.identifier.scopusauthoridLin, CK=15034856400en_HK

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