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Article: Liver graft-versus-host disease after donor lymphocyte infusion for relapses of hematologic malignancies post allogeneic hematopoietic stem cell transplantation

TitleLiver graft-versus-host disease after donor lymphocyte infusion for relapses of hematologic malignancies post allogeneic hematopoietic stem cell transplantation
Authors
KeywordsDLI
HSCT
Liver GVHD
Issue Date2004
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bmt
Citation
Bone Marrow Transplantation, 2004, v. 34 n. 1, p. 57-61 How to Cite?
AbstractGraft-versus-host disease (GVHD) is the commonest complication after donor lymphocyte infusion (DLI). In 19 patients undergoing DLI for relapses of hematologic malignancies post hematopoietic stem cell transplantation (HSCT), 11 developed GVHD, of whom nine had isolated liver involvement, and two had liver and skin involvement. The clinical diagnosis of liver GVHD was hepatitic in six patients (55%) and classical in five patients (45%). Patients with GVHD post-DLI showed a different clinical pattern when compared to a cohort of 106 cases of GVHD post-HSCT, in having significantly more isolated liver involvement (9/11 vs 17/106, P<0.001), and less skin (2/11 vs 80/106, P<0.001) and gut (0/11 vs 28/106, P<0.001) involvement. However, liver GVHD post-DLI and post-HSCT had comparable patient characteristics, underlying diseases, clinical subtypes (classical and hepatitic) and response to treatment. © 2004 Nature Publishing Group All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/76282
ISSN
2015 Impact Factor: 3.636
2015 SCImago Journal Rankings: 1.585
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMa, SYen_HK
dc.contributor.authorAu, WYen_HK
dc.contributor.authorLie, AKWen_HK
dc.contributor.authorNg, IOLen_HK
dc.contributor.authorLeung, AYHen_HK
dc.contributor.authorTse, EWen_HK
dc.contributor.authorLiang, RHen_HK
dc.contributor.authorLau, GKen_HK
dc.contributor.authorKwong, YLen_HK
dc.date.accessioned2010-09-06T07:19:34Z-
dc.date.available2010-09-06T07:19:34Z-
dc.date.issued2004en_HK
dc.identifier.citationBone Marrow Transplantation, 2004, v. 34 n. 1, p. 57-61en_HK
dc.identifier.issn0268-3369en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76282-
dc.description.abstractGraft-versus-host disease (GVHD) is the commonest complication after donor lymphocyte infusion (DLI). In 19 patients undergoing DLI for relapses of hematologic malignancies post hematopoietic stem cell transplantation (HSCT), 11 developed GVHD, of whom nine had isolated liver involvement, and two had liver and skin involvement. The clinical diagnosis of liver GVHD was hepatitic in six patients (55%) and classical in five patients (45%). Patients with GVHD post-DLI showed a different clinical pattern when compared to a cohort of 106 cases of GVHD post-HSCT, in having significantly more isolated liver involvement (9/11 vs 17/106, P<0.001), and less skin (2/11 vs 80/106, P<0.001) and gut (0/11 vs 28/106, P<0.001) involvement. However, liver GVHD post-DLI and post-HSCT had comparable patient characteristics, underlying diseases, clinical subtypes (classical and hepatitic) and response to treatment. © 2004 Nature Publishing Group All rights reserved.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bmten_HK
dc.relation.ispartofBone Marrow Transplantationen_HK
dc.subjectDLIen_HK
dc.subjectHSCTen_HK
dc.subjectLiver GVHDen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGraft vs Host Disease - drug therapy - etiology - pathologyen_HK
dc.subject.meshHematologic Neoplasms - complications - therapyen_HK
dc.subject.meshHematopoietic Stem Cell Transplantation - adverse effects - methodsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLiver Diseases - drug therapy - etiologyen_HK
dc.subject.meshLymphocyte Transfusion - adverse effectsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshRecurrenceen_HK
dc.subject.meshRetrospective Studiesen_HK
dc.subject.meshTransplantation, Homologousen_HK
dc.subject.meshTreatment Outcomeen_HK
dc.titleLiver graft-versus-host disease after donor lymphocyte infusion for relapses of hematologic malignancies post allogeneic hematopoietic stem cell transplantationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0268-3369&volume=34&spage=57&epage=61&date=2004&atitle=Liver+graft-versus-host+disease+after+donor+lymphocyte+infusion+for+relapses+of+hematologic+malignancies+post+allogeneic+hematopoietic+stem+cell+transplantationen_HK
dc.identifier.emailNg, IOL:iolng@hkucc.hku.hken_HK
dc.identifier.emailLeung, AYH:ayhleung@hku.hken_HK
dc.identifier.emailTse, EW:ewctse@hku.hken_HK
dc.identifier.emailLiang, RH:rliang@hku.hken_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.authorityNg, IOL=rp00335en_HK
dc.identifier.authorityLeung, AYH=rp00265en_HK
dc.identifier.authorityTse, EW=rp00471en_HK
dc.identifier.authorityLiang, RH=rp00345en_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/sj.bmt.1704522en_HK
dc.identifier.pmid15156162-
dc.identifier.scopuseid_2-s2.0-3543115484en_HK
dc.identifier.hkuros94889en_HK
dc.identifier.hkuros100619-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-3543115484&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume34en_HK
dc.identifier.issue1en_HK
dc.identifier.spage57en_HK
dc.identifier.epage61en_HK
dc.identifier.isiWOS:000222136300008-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridMa, SY=7403725725en_HK
dc.identifier.scopusauthoridAu, WY=7202383089en_HK
dc.identifier.scopusauthoridLie, AKW=24284842400en_HK
dc.identifier.scopusauthoridNg, IOL=7102753722en_HK
dc.identifier.scopusauthoridLeung, AYH=7403012668en_HK
dc.identifier.scopusauthoridTse, EW=7005019454en_HK
dc.identifier.scopusauthoridLiang, RH=26643224900en_HK
dc.identifier.scopusauthoridLau, GK=7102301257en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK

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