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Article: Urotensin II and the circulatory system

TitleUrotensin II and the circulatory system
Authors
KeywordsHypertension
Renal failure
Urotensin
Vasoactive peptides
Vasoconstriction
Issue Date2005
PublisherLippincott Williams & Wilkins Asia. The Journal's web site is located at http://www.hkjn.org/
Citation
Hong Kong Journal Of Nephrology, 2005, v. 7 n. 1, p. 9-13 How to Cite?
AbstractUrotensin II (UII), first isolated from the spinal cord of teleost fish, is the most potent vasoconstrictor known. It is more potent than endothelin-1 and acts through UT-II, a seven-transmembrane-domain, G-protein-coupled receptor. Human UII is an 11-amino-acid cyclic peptide that is expressed in various tissues, including the central nervous system, heart, kidney, and blood vessels. It circulates in human plasma, and its plasma level is elevated in renal failure, congestive heart failure, diabetes, and portal hypertension. In the kidney, UII has vasodilatory and natriuretic effects, mediated through nitric oxide. The development of UII-receptor antagonists may provide a useful research tool, and a novel treatment for cardiorenal diseases.
Persistent Identifierhttp://hdl.handle.net/10722/76281
ISSN
2015 SCImago Journal Rankings: 0.166
References

 

DC FieldValueLanguage
dc.contributor.authorOng, KLen_HK
dc.contributor.authorCheung, BMYen_HK
dc.contributor.authorLam, KSLen_HK
dc.date.accessioned2010-09-06T07:19:33Z-
dc.date.available2010-09-06T07:19:33Z-
dc.date.issued2005en_HK
dc.identifier.citationHong Kong Journal Of Nephrology, 2005, v. 7 n. 1, p. 9-13en_HK
dc.identifier.issn1561-5413en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76281-
dc.description.abstractUrotensin II (UII), first isolated from the spinal cord of teleost fish, is the most potent vasoconstrictor known. It is more potent than endothelin-1 and acts through UT-II, a seven-transmembrane-domain, G-protein-coupled receptor. Human UII is an 11-amino-acid cyclic peptide that is expressed in various tissues, including the central nervous system, heart, kidney, and blood vessels. It circulates in human plasma, and its plasma level is elevated in renal failure, congestive heart failure, diabetes, and portal hypertension. In the kidney, UII has vasodilatory and natriuretic effects, mediated through nitric oxide. The development of UII-receptor antagonists may provide a useful research tool, and a novel treatment for cardiorenal diseases.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins Asia. The Journal's web site is located at http://www.hkjn.org/en_HK
dc.relation.ispartofHong Kong Journal of Nephrologyen_HK
dc.subjectHypertensionen_HK
dc.subjectRenal failureen_HK
dc.subjectUrotensinen_HK
dc.subjectVasoactive peptidesen_HK
dc.subjectVasoconstrictionen_HK
dc.titleUrotensin II and the circulatory systemen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1561-5413&volume=7&issue=1&spage=9&epage=13&date=2005&atitle=Urotensin+II+and+the+circulatory+systemen_HK
dc.identifier.emailCheung, BMY:mycheung@hku.hken_HK
dc.identifier.emailLam, KSL:ksllam@hku.hken_HK
dc.identifier.authorityCheung, BMY=rp01321en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-18144423519en_HK
dc.identifier.hkuros108708en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-18144423519&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume7en_HK
dc.identifier.issue1en_HK
dc.identifier.spage9en_HK
dc.identifier.epage13en_HK
dc.publisher.placeHong Kongen_HK
dc.identifier.scopusauthoridOng, KL=8340854000en_HK
dc.identifier.scopusauthoridCheung, BMY=7103294806en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK

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