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Article: A long-term study on hyperlipidemia in stable renal transplant recipients
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TitleA long-term study on hyperlipidemia in stable renal transplant recipients
 
AuthorsTse, KC1
Lam, MF1
Yip, PS1
Li, FK1
Lai, KN1
Chan, TM1
 
KeywordsHypercholesterolemia
Hyperlipidemia
Incidence
Prevalence
Renal transplant
 
Issue Date2004
 
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CTR
 
CitationClinical Transplantation, 2004, v. 18 n. 3, p. 274-280 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1399-0012.2004.00160.x
 
AbstractObjectives: Hyperlipidemia is a common and important risk factor after renal transplantation, but there is little long-term data on its incidence, pattern, and evolution in stable renal allograft recipients on low dose maintenance immunosuppression. Patients and methods: A retrospective study was conducted on all patients who received kidney transplants from April 1, 1990 to March 31, 2000 at a single center, on their serial lipid profile during the first 3 yr after kidney transplantation. Results: A total of 221 (122 male, 99 female; mean age 37.8 ± 10.0 yr at the time of transplantation) Chinese adult renal allograft recipients were included. A 95.3% of patients were on cyclosporine and prednisolone based immunosuppression. Increases in total cholesterol (TC), low density lipoprotein (LDL), and high density lipoprotein (HDL) were noted, while the level of triglyceride (TG) decreased after renal transplant. The incidence of hypercholesterolemia (defined as TC ≥ 6.3 mmol/L or LDL ≥ 4.2 mmol/L) within the first year was 28.2 and 20.3%, respectively. The incidence rate decreased significantly in the second (5.4%, p = 0.000 and 6.4%, p = 0.003) and third year (9.5%, p = 0.003 and 4.9%, p = 0.021), but the incidence of patients having a high risk-ratio (defined as TC/HDL ≥ 5) remained unchanged (6.9, 4.9 and 10.3% within the first, second, and third year, respectively). Treatment with statin was necessitated in 6.8, 13.6 and 21.7% of the patients at 1, 2, and 3 yr after transplantation, respectively. The prevalence rates of elevated TC and LDL were 18.3 and 18.9% at baseline, 40.6 and 33.3% after 1 yr, 32.8 and 27.3% after 2 yr, and 24.8 and 19.0% after 3 yr, despite treatment. The prevalence of patients with a high risk-ratio was 45.0% at baseline, 30.5% after 1 yr (p = 0.002), 22.6% after 2 yr (p = 0.000) and 21.8% after 3 yr (p = 0.000). Hypercholesterolemia at the time of transplantation was an independent predictor for post-transplant hypercholesterolemia (odds ratio 3.76, 95% confidence interval 1.47-9.62, p = 0.006). Conclusion: Renal transplantation is associated with a characteristic pattern of dyslipidemia, with increased TC, LDL and HDL, and a decrease in TG. Patients with pre-existing hypercholesterolemia were at higher risk for post-transplant hypercholesterolemia. Although the incidence of hypercholesterolemia peaks within the first year after transplantation, this remains a long-term complication in a significant proportion of patients on low dose immunosuppressive medications. © Blackwell Munksgaard, 2004.
 
ISSN0902-0063
2013 Impact Factor: 1.486
 
DOIhttp://dx.doi.org/10.1111/j.1399-0012.2004.00160.x
 
ISI Accession Number IDWOS:000221354400008
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorTse, KC
 
dc.contributor.authorLam, MF
 
dc.contributor.authorYip, PS
 
dc.contributor.authorLi, FK
 
dc.contributor.authorLai, KN
 
dc.contributor.authorChan, TM
 
dc.date.accessioned2010-09-06T07:19:26Z
 
dc.date.available2010-09-06T07:19:26Z
 
dc.date.issued2004
 
dc.description.abstractObjectives: Hyperlipidemia is a common and important risk factor after renal transplantation, but there is little long-term data on its incidence, pattern, and evolution in stable renal allograft recipients on low dose maintenance immunosuppression. Patients and methods: A retrospective study was conducted on all patients who received kidney transplants from April 1, 1990 to March 31, 2000 at a single center, on their serial lipid profile during the first 3 yr after kidney transplantation. Results: A total of 221 (122 male, 99 female; mean age 37.8 ± 10.0 yr at the time of transplantation) Chinese adult renal allograft recipients were included. A 95.3% of patients were on cyclosporine and prednisolone based immunosuppression. Increases in total cholesterol (TC), low density lipoprotein (LDL), and high density lipoprotein (HDL) were noted, while the level of triglyceride (TG) decreased after renal transplant. The incidence of hypercholesterolemia (defined as TC ≥ 6.3 mmol/L or LDL ≥ 4.2 mmol/L) within the first year was 28.2 and 20.3%, respectively. The incidence rate decreased significantly in the second (5.4%, p = 0.000 and 6.4%, p = 0.003) and third year (9.5%, p = 0.003 and 4.9%, p = 0.021), but the incidence of patients having a high risk-ratio (defined as TC/HDL ≥ 5) remained unchanged (6.9, 4.9 and 10.3% within the first, second, and third year, respectively). Treatment with statin was necessitated in 6.8, 13.6 and 21.7% of the patients at 1, 2, and 3 yr after transplantation, respectively. The prevalence rates of elevated TC and LDL were 18.3 and 18.9% at baseline, 40.6 and 33.3% after 1 yr, 32.8 and 27.3% after 2 yr, and 24.8 and 19.0% after 3 yr, despite treatment. The prevalence of patients with a high risk-ratio was 45.0% at baseline, 30.5% after 1 yr (p = 0.002), 22.6% after 2 yr (p = 0.000) and 21.8% after 3 yr (p = 0.000). Hypercholesterolemia at the time of transplantation was an independent predictor for post-transplant hypercholesterolemia (odds ratio 3.76, 95% confidence interval 1.47-9.62, p = 0.006). Conclusion: Renal transplantation is associated with a characteristic pattern of dyslipidemia, with increased TC, LDL and HDL, and a decrease in TG. Patients with pre-existing hypercholesterolemia were at higher risk for post-transplant hypercholesterolemia. Although the incidence of hypercholesterolemia peaks within the first year after transplantation, this remains a long-term complication in a significant proportion of patients on low dose immunosuppressive medications. © Blackwell Munksgaard, 2004.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationClinical Transplantation, 2004, v. 18 n. 3, p. 274-280 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1399-0012.2004.00160.x
 
dc.identifier.doihttp://dx.doi.org/10.1111/j.1399-0012.2004.00160.x
 
dc.identifier.epage280
 
dc.identifier.hkuros86752
 
dc.identifier.isiWOS:000221354400008
 
dc.identifier.issn0902-0063
2013 Impact Factor: 1.486
 
dc.identifier.issue3
 
dc.identifier.openurl
 
dc.identifier.pmid15142048
 
dc.identifier.scopuseid_2-s2.0-2342667679
 
dc.identifier.spage274
 
dc.identifier.urihttp://hdl.handle.net/10722/76269
 
dc.identifier.volume18
 
dc.languageeng
 
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CTR
 
dc.publisher.placeDenmark
 
dc.relation.ispartofClinical Transplantation
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdrenal Cortex Hormones - adverse effects
 
dc.subject.meshAdult
 
dc.subject.meshCyclosporine - adverse effects
 
dc.subject.meshDiet
 
dc.subject.meshFemale
 
dc.subject.meshHong Kong
 
dc.subject.meshHumans
 
dc.subject.meshHyperlipidemias - complications - epidemiology
 
dc.subject.meshImmunosuppressive Agents - adverse effects
 
dc.subject.meshIncidence
 
dc.subject.meshKidney Transplantation - adverse effects
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshPrevalence
 
dc.subject.meshRetrospective Studies
 
dc.subject.meshRisk Factors
 
dc.subject.meshTime Factors
 
dc.subjectHypercholesterolemia
 
dc.subjectHyperlipidemia
 
dc.subjectIncidence
 
dc.subjectPrevalence
 
dc.subjectRenal transplant
 
dc.titleA long-term study on hyperlipidemia in stable renal transplant recipients
 
dc.typeArticle
 
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<contributor.author>Lam, MF</contributor.author>
<contributor.author>Yip, PS</contributor.author>
<contributor.author>Li, FK</contributor.author>
<contributor.author>Lai, KN</contributor.author>
<contributor.author>Chan, TM</contributor.author>
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<description.abstract>Objectives: Hyperlipidemia is a common and important risk factor after renal transplantation, but there is little long-term data on its incidence, pattern, and evolution in stable renal allograft recipients on low dose maintenance immunosuppression. Patients and methods: A retrospective study was conducted on all patients who received kidney transplants from April 1, 1990 to March 31, 2000 at a single center, on their serial lipid profile during the first 3 yr after kidney transplantation. Results: A total of 221 (122 male, 99 female; mean age 37.8 &#177; 10.0 yr at the time of transplantation) Chinese adult renal allograft recipients were included. A 95.3% of patients were on cyclosporine and prednisolone based immunosuppression. Increases in total cholesterol (TC), low density lipoprotein (LDL), and high density lipoprotein (HDL) were noted, while the level of triglyceride (TG) decreased after renal transplant. The incidence of hypercholesterolemia (defined as TC &#8805; 6.3 mmol/L or LDL &#8805; 4.2 mmol/L) within the first year was 28.2 and 20.3%, respectively. The incidence rate decreased significantly in the second (5.4%, p = 0.000 and 6.4%, p = 0.003) and third year (9.5%, p = 0.003 and 4.9%, p = 0.021), but the incidence of patients having a high risk-ratio (defined as TC/HDL &#8805; 5) remained unchanged (6.9, 4.9 and 10.3% within the first, second, and third year, respectively). Treatment with statin was necessitated in 6.8, 13.6 and 21.7% of the patients at 1, 2, and 3 yr after transplantation, respectively. The prevalence rates of elevated TC and LDL were 18.3 and 18.9% at baseline, 40.6 and 33.3% after 1 yr, 32.8 and 27.3% after 2 yr, and 24.8 and 19.0% after 3 yr, despite treatment. The prevalence of patients with a high risk-ratio was 45.0% at baseline, 30.5% after 1 yr (p = 0.002), 22.6% after 2 yr (p = 0.000) and 21.8% after 3 yr (p = 0.000). Hypercholesterolemia at the time of transplantation was an independent predictor for post-transplant hypercholesterolemia (odds ratio 3.76, 95% confidence interval 1.47-9.62, p = 0.006). Conclusion: Renal transplantation is associated with a characteristic pattern of dyslipidemia, with increased TC, LDL and HDL, and a decrease in TG. Patients with pre-existing hypercholesterolemia were at higher risk for post-transplant hypercholesterolemia. Although the incidence of hypercholesterolemia peaks within the first year after transplantation, this remains a long-term complication in a significant proportion of patients on low dose immunosuppressive medications. &#169; Blackwell Munksgaard, 2004.</description.abstract>
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<subject>Hypercholesterolemia</subject>
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Author Affiliations
  1. The University of Hong Kong