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Article: Deregulation of E-cadherin-catenin complex in precancerous lesions of gastric adenocarcinoma

TitleDeregulation of E-cadherin-catenin complex in precancerous lesions of gastric adenocarcinoma
Authors
KeywordsCatenin
E-cadherin
Gastric cancer
Intestinal metaplasia
Issue Date2003
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGH
Citation
Journal Of Gastroenterology And Hepatology, 2003, v. 18 n. 5, p. 534-539 How to Cite?
AbstractBackground and Aim: Decrease in expression of the E-cadherin-catenin complex is an important element in gastric carcinogenesis. However, the expression of the complex in gastric precancerous lesions has not been well studied. The present study aimed to examine the serial change in expression of E-cadherin-catenin complex in the precancerous lesions of gastric cancer patients. Methods: Gastrectomy specimens of 40 patients with gastric cancer were retrieved. Areas with chronic gastritis, atrophic gastritis, intestinal metaplasia and adenocarcinoma were identified and immunostained for α-catenin, β-catenin and E-cadherin. The results were scored semiquantitatively by two independent pathologists using a validated scoring system. Results: A significant decrease in score was observed in 5% (1/22) of α-catenin, 0% (0/22) of β-catenin and 9% (2/22) of E-cadherin in chronic atrophic gastritis patients, and in 28% (5/18) of α-catenin, 67% (10/15) of β-catenin and 57% (8/14) of E-cadherin in intestinal metaplasia patients. The scoring of α-catenin, β-catenin and E-cadherin correlated with each other. Forty-three percent of patients had concordant changes of scores along the gastritis-adenocarcinoma sequence. There was no association between Helicobacter pylori status and E-cadherin-catenin complex expression. Conclusion: Deregulation of the E-cadherin-catenin complex was observed in the majority of precancerous lesions in patients with gastric adenocarcinoma, which has potential diagnostic and therapeutic implications. © 2003 Blackwell Publishing Asia Pty Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/76224
ISSN
2015 Impact Factor: 3.322
2015 SCImago Journal Rankings: 1.190
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, AOOen_HK
dc.contributor.authorWong, BCYen_HK
dc.contributor.authorLan, HYen_HK
dc.contributor.authorLoke, SLen_HK
dc.contributor.authorChan, WKen_HK
dc.contributor.authorHui, WMen_HK
dc.contributor.authorYuen, YHen_HK
dc.contributor.authorNg, Ien_HK
dc.contributor.authorHou, Len_HK
dc.contributor.authorWong, WMen_HK
dc.contributor.authorYuen, MFen_HK
dc.contributor.authorLuk, JMCen_HK
dc.contributor.authorLam, SKen_HK
dc.date.accessioned2010-09-06T07:18:55Z-
dc.date.available2010-09-06T07:18:55Z-
dc.date.issued2003en_HK
dc.identifier.citationJournal Of Gastroenterology And Hepatology, 2003, v. 18 n. 5, p. 534-539en_HK
dc.identifier.issn0815-9319en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76224-
dc.description.abstractBackground and Aim: Decrease in expression of the E-cadherin-catenin complex is an important element in gastric carcinogenesis. However, the expression of the complex in gastric precancerous lesions has not been well studied. The present study aimed to examine the serial change in expression of E-cadherin-catenin complex in the precancerous lesions of gastric cancer patients. Methods: Gastrectomy specimens of 40 patients with gastric cancer were retrieved. Areas with chronic gastritis, atrophic gastritis, intestinal metaplasia and adenocarcinoma were identified and immunostained for α-catenin, β-catenin and E-cadherin. The results were scored semiquantitatively by two independent pathologists using a validated scoring system. Results: A significant decrease in score was observed in 5% (1/22) of α-catenin, 0% (0/22) of β-catenin and 9% (2/22) of E-cadherin in chronic atrophic gastritis patients, and in 28% (5/18) of α-catenin, 67% (10/15) of β-catenin and 57% (8/14) of E-cadherin in intestinal metaplasia patients. The scoring of α-catenin, β-catenin and E-cadherin correlated with each other. Forty-three percent of patients had concordant changes of scores along the gastritis-adenocarcinoma sequence. There was no association between Helicobacter pylori status and E-cadherin-catenin complex expression. Conclusion: Deregulation of the E-cadherin-catenin complex was observed in the majority of precancerous lesions in patients with gastric adenocarcinoma, which has potential diagnostic and therapeutic implications. © 2003 Blackwell Publishing Asia Pty Ltd.en_HK
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGHen_HK
dc.relation.ispartofJournal of Gastroenterology and Hepatologyen_HK
dc.subjectCateninen_HK
dc.subjectE-cadherinen_HK
dc.subjectGastric canceren_HK
dc.subjectIntestinal metaplasiaen_HK
dc.subject.meshAdenocarcinoma - metabolism - pathologyen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshCadherins - metabolismen_HK
dc.subject.meshCytoskeletal Proteins - metabolismen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunoenzyme Techniquesen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNeoplasm Stagingen_HK
dc.subject.meshPrecancerous Conditions - metabolism - pathologyen_HK
dc.subject.meshStomach Neoplasms - metabolism - pathologyen_HK
dc.subject.meshTrans-Activators - metabolismen_HK
dc.subject.meshTumor Markers, Biological - metabolismen_HK
dc.subject.meshalpha Cateninen_HK
dc.subject.meshbeta Cateninen_HK
dc.titleDeregulation of E-cadherin-catenin complex in precancerous lesions of gastric adenocarcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0815-9319&volume=18&spage=534&epage=539&date=2003&atitle=Deregulation+of+E-cadherin-catenin+complex+in+precancerous+lesions+of+gastric+adenocarcinomaen_HK
dc.identifier.emailWong, BCY: bcywong@hku.hken_HK
dc.identifier.emailNg, I: iolng@hkucc.hku.hken_HK
dc.identifier.emailYuen, MF: mfyuen@hkucc.hku.hken_HK
dc.identifier.emailLuk, JMC: jmluk@hkucc.hku.hken_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.identifier.authorityNg, I=rp00335en_HK
dc.identifier.authorityYuen, MF=rp00479en_HK
dc.identifier.authorityLuk, JMC=rp00349en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1046/j.1440-1746.2003.02998.xen_HK
dc.identifier.pmid12702045-
dc.identifier.scopuseid_2-s2.0-0037716553en_HK
dc.identifier.hkuros76971en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037716553&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume18en_HK
dc.identifier.issue5en_HK
dc.identifier.spage534en_HK
dc.identifier.epage539en_HK
dc.identifier.isiWOS:000182303500008-
dc.publisher.placeAustraliaen_HK
dc.identifier.scopusauthoridChan, AOO=7403167965en_HK
dc.identifier.scopusauthoridWong, BCY=7402023340en_HK
dc.identifier.scopusauthoridLan, HY=7102710832en_HK
dc.identifier.scopusauthoridLoke, SL=7006559512en_HK
dc.identifier.scopusauthoridChan, WK=14423963400en_HK
dc.identifier.scopusauthoridHui, WM=7103196477en_HK
dc.identifier.scopusauthoridYuen, YH=7003269009en_HK
dc.identifier.scopusauthoridNg, I=7102753722en_HK
dc.identifier.scopusauthoridHou, L=7202492220en_HK
dc.identifier.scopusauthoridWong, WM=7403972413en_HK
dc.identifier.scopusauthoridYuen, MF=7102031955en_HK
dc.identifier.scopusauthoridLuk, JMC=7006777791en_HK
dc.identifier.scopusauthoridLam, SK=7402279473en_HK

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