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Article: MRI visualization of rodent liver structure and peritoneal adhesion with dialyzate enhancement

TitleMRI visualization of rodent liver structure and peritoneal adhesion with dialyzate enhancement
Authors
KeywordsDialyzate
Intraperitoneal enhancement
MRI
Peritoneal adhesion
Peritoneal dialysis fluid
Rodent liver
Issue Date2008
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0740-3194/
Citation
Magnetic Resonance In Medicine, 2008, v. 59 n. 5, p. 1170-1174 How to Cite?
AbstractThis study investigated the use of peritoneal dialysis fluid (dialyzate) as a MR contrast agent to visualize the liver structure and peritoneal adhesion in rats at 7 T. Intraperitoneal injection of dialyzate (∼0.1 ml/g) yielded excellent and consistent intraperitoneal enhancement that delineated the liver lobular structure in all rats studied (N = 8). It also allowed the MR detection of peritoneal adhesions that were surgically induced. MR measurements of adhesion surface areas correlated well with the postmortem estimations (R = 0.99; N = 6). Dialyzate persisted in the intraperitoneal cavity for up to 2 days. T 1 and T 2 values of undiluted dialyzate were found to be 3017.5 ± 35.3 ms and 108.4 ± 2.0 ms, respectively. These findings demonstrated dialyzate-enhanced MRI as a potentially valuable technique to localize certain activities within liver (such as local tumor metastasis), and to monitor therapeutic interventions (e.g., against peritoneal adhesion) in preclinical research using small animal models. © 2008 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/73796
ISSN
2015 Impact Factor: 3.782
2015 SCImago Journal Rankings: 2.197
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, JSen_HK
dc.contributor.authorGuo, Hen_HK
dc.contributor.authorLeung, JCKen_HK
dc.contributor.authorMan, Ken_HK
dc.contributor.authorLai, KNen_HK
dc.contributor.authorWu, EXen_HK
dc.date.accessioned2010-09-06T06:54:50Z-
dc.date.available2010-09-06T06:54:50Z-
dc.date.issued2008en_HK
dc.identifier.citationMagnetic Resonance In Medicine, 2008, v. 59 n. 5, p. 1170-1174en_HK
dc.identifier.issn0740-3194en_HK
dc.identifier.urihttp://hdl.handle.net/10722/73796-
dc.description.abstractThis study investigated the use of peritoneal dialysis fluid (dialyzate) as a MR contrast agent to visualize the liver structure and peritoneal adhesion in rats at 7 T. Intraperitoneal injection of dialyzate (∼0.1 ml/g) yielded excellent and consistent intraperitoneal enhancement that delineated the liver lobular structure in all rats studied (N = 8). It also allowed the MR detection of peritoneal adhesions that were surgically induced. MR measurements of adhesion surface areas correlated well with the postmortem estimations (R = 0.99; N = 6). Dialyzate persisted in the intraperitoneal cavity for up to 2 days. T 1 and T 2 values of undiluted dialyzate were found to be 3017.5 ± 35.3 ms and 108.4 ± 2.0 ms, respectively. These findings demonstrated dialyzate-enhanced MRI as a potentially valuable technique to localize certain activities within liver (such as local tumor metastasis), and to monitor therapeutic interventions (e.g., against peritoneal adhesion) in preclinical research using small animal models. © 2008 Wiley-Liss, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0740-3194/en_HK
dc.relation.ispartofMagnetic Resonance in Medicineen_HK
dc.rightsMagnetic Resonance in Medicine. Copyright © John Wiley & Sons, Inc.en_HK
dc.subjectDialyzateen_HK
dc.subjectIntraperitoneal enhancementen_HK
dc.subjectMRIen_HK
dc.subjectPeritoneal adhesionen_HK
dc.subjectPeritoneal dialysis fluiden_HK
dc.subjectRodent liveren_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshContrast Mediaen_HK
dc.subject.meshDialysis Solutions - diagnostic useen_HK
dc.subject.meshLiver - anatomy & histologyen_HK
dc.subject.meshMagnetic Resonance Imaging - methodsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshPeritoneal Cavityen_HK
dc.subject.meshPeritoneal Dialysisen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshTissue Adhesions - diagnosisen_HK
dc.titleMRI visualization of rodent liver structure and peritoneal adhesion with dialyzate enhancementen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0740-3194&volume=59&spage=1170&epage=4&date=2008&atitle=MRI+visualization+of+rodent+liver+structure+and+peritoneal+adhesion+with+dialyzate+enhancementen_HK
dc.identifier.emailLeung, JCK: jckleung@hku.hken_HK
dc.identifier.emailMan, K: kwanman@hku.hken_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.emailWu, EX: ewu1@hkucc.hku.hken_HK
dc.identifier.authorityLeung, JCK=rp00448en_HK
dc.identifier.authorityMan, K=rp00417en_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/mrm.21506en_HK
dc.identifier.pmid18429030-
dc.identifier.scopuseid_2-s2.0-42549169690en_HK
dc.identifier.hkuros149221en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-42549169690&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume59en_HK
dc.identifier.issue5en_HK
dc.identifier.spage1170en_HK
dc.identifier.epage1174en_HK
dc.identifier.isiWOS:000255230700027-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCheung, JS=16174280400en_HK
dc.identifier.scopusauthoridGuo, H=55468645700en_HK
dc.identifier.scopusauthoridLeung, JCK=7202180349en_HK
dc.identifier.scopusauthoridMan, K=7101754072en_HK
dc.identifier.scopusauthoridLai, KN=7402135706en_HK
dc.identifier.scopusauthoridWu, EX=7202128034en_HK

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