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Article: Coronary atherosclerosis using computed tomography coronary angiography in patients with systemic sclerosis

TitleCoronary atherosclerosis using computed tomography coronary angiography in patients with systemic sclerosis
Authors
Issue Date2009
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/03009742.asp
Citation
Scandinavian Journal Of Rheumatology, 2009, v. 38 n. 5, p. 381-385 How to Cite?
AbstractBackground: Impaired coronary artery reserve has previously been demonstrated in patients with systemic sclerosis (SSc). Both micro- and macrovascular factors are probably contributory to the underlying pathogenesis. Objectives: To examine the frequency of coronary atherosclerosis in a series of SSc patients by computed tomography coronary angiography (CTCA), a less invasive method than conventional coronary angiography, the current gold standard in the detection of coronary atherosclerosis, and to explore its clinical associations. Methods: Nineteen consecutive SSc patients [six with diffuse (dSSc) and 13 with limited disease (lSSc)] with disease duration of ≥ 3 years were recruited. Coronary calcium score and contrast angiography were examined by CT scan. Conventional cardiovascular factors and inflammatory markers were measured and correlated with CT findings. Results: The mean±SD age of these patients was 52.5±12.5 years with median disease duration of 12.5 years. Six (31.6%) patients were found to have coronary artery calcification (calcium score 132008). Coronary calcium was detected in one dSSc patient but contrast angiography was not performed because of interference from an in situ implantable cardiac device. Some parts of the coronary arteries were not assessable in two patients who had ectopic cardiac rhythm. Five lSSc patients had calcified plaques causing variable coronary luminal stenosis. All patients were asymptomatic. Patients with abnormal CTCA findings were more likely to be older (p < 0.001) and were less likely to have serum anti-Scl70 antibodies (p = 0.003) than those without, after Bonferroni correction. Conclusions: Coronary atherosclerosis is not uncommon in asymptomatic SSc patients. CTCA is a convenient and non-invasive method for studying coronary atherosclerosis. © 2009 Taylor & Francis on license from Scandinavian Rheumatology Research Foundation.
Persistent Identifierhttp://hdl.handle.net/10722/72347
ISSN
2015 Impact Factor: 2.307
2015 SCImago Journal Rankings: 1.125
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Arthritis and Rheumatism Foundation Research Fund
Funding Information:

This study was supported by the Hong Kong Arthritis and Rheumatism Foundation Research Fund.

References

 

DC FieldValueLanguage
dc.contributor.authorMok, MYen_HK
dc.contributor.authorChiu, SSHen_HK
dc.contributor.authorLo, Yen_HK
dc.contributor.authorMak, HKFen_HK
dc.contributor.authorWong, WSen_HK
dc.contributor.authorKhong, PLen_HK
dc.contributor.authorLau, CSen_HK
dc.date.accessioned2010-09-06T06:40:46Z-
dc.date.available2010-09-06T06:40:46Z-
dc.date.issued2009en_HK
dc.identifier.citationScandinavian Journal Of Rheumatology, 2009, v. 38 n. 5, p. 381-385en_HK
dc.identifier.issn0300-9742en_HK
dc.identifier.urihttp://hdl.handle.net/10722/72347-
dc.description.abstractBackground: Impaired coronary artery reserve has previously been demonstrated in patients with systemic sclerosis (SSc). Both micro- and macrovascular factors are probably contributory to the underlying pathogenesis. Objectives: To examine the frequency of coronary atherosclerosis in a series of SSc patients by computed tomography coronary angiography (CTCA), a less invasive method than conventional coronary angiography, the current gold standard in the detection of coronary atherosclerosis, and to explore its clinical associations. Methods: Nineteen consecutive SSc patients [six with diffuse (dSSc) and 13 with limited disease (lSSc)] with disease duration of ≥ 3 years were recruited. Coronary calcium score and contrast angiography were examined by CT scan. Conventional cardiovascular factors and inflammatory markers were measured and correlated with CT findings. Results: The mean±SD age of these patients was 52.5±12.5 years with median disease duration of 12.5 years. Six (31.6%) patients were found to have coronary artery calcification (calcium score 132008). Coronary calcium was detected in one dSSc patient but contrast angiography was not performed because of interference from an in situ implantable cardiac device. Some parts of the coronary arteries were not assessable in two patients who had ectopic cardiac rhythm. Five lSSc patients had calcified plaques causing variable coronary luminal stenosis. All patients were asymptomatic. Patients with abnormal CTCA findings were more likely to be older (p < 0.001) and were less likely to have serum anti-Scl70 antibodies (p = 0.003) than those without, after Bonferroni correction. Conclusions: Coronary atherosclerosis is not uncommon in asymptomatic SSc patients. CTCA is a convenient and non-invasive method for studying coronary atherosclerosis. © 2009 Taylor & Francis on license from Scandinavian Rheumatology Research Foundation.en_HK
dc.languageengen_HK
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/03009742.aspen_HK
dc.relation.ispartofScandinavian Journal of Rheumatologyen_HK
dc.rightsScandinavian Journal of Rheumatology. Copyright © Informa Healthcare.en_HK
dc.subject.meshCalcinosis - pathology - radiography-
dc.subject.meshCoronary Angiography-
dc.subject.meshCoronary Artery Disease - complications - radiography-
dc.subject.meshScleroderma, Systemic - complications - pathology-
dc.subject.meshStatistics, Nonparametric-
dc.titleCoronary atherosclerosis using computed tomography coronary angiography in patients with systemic sclerosisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0300-9742&volume=38&issue=5&spage=381&epage=385&date=2009&atitle=Coronary+atherosclerosis+using+CT+coronary+angiogram+in+patients+with+systemic+sclerosisen_HK
dc.identifier.emailMok, MY:temy@hkucc.hku.hken_HK
dc.identifier.emailLo, Y:yve_lo@yahoo.com.hken_HK
dc.identifier.emailMak, HKF:makkf@hkucc.hku.hken_HK
dc.identifier.emailKhong, PL:plkhong@hkucc.hku.hken_HK
dc.identifier.emailLau, CS:cslau@hku.hken_HK
dc.identifier.authorityMok, MY=rp00490en_HK
dc.identifier.authorityLo, Y=rp00512en_HK
dc.identifier.authorityMak, HKF=rp00533en_HK
dc.identifier.authorityKhong, PL=rp00467en_HK
dc.identifier.authorityLau, CS=rp01348en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1080/03009740902992979en_HK
dc.identifier.pmid19585378-
dc.identifier.scopuseid_2-s2.0-70350042049en_HK
dc.identifier.hkuros160318en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70350042049&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume38en_HK
dc.identifier.issue5en_HK
dc.identifier.spage381en_HK
dc.identifier.epage385en_HK
dc.identifier.isiWOS:000271468400012-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridMok, MY=7006024184en_HK
dc.identifier.scopusauthoridChiu, SSH=34973870500en_HK
dc.identifier.scopusauthoridLo, Y=16022308000en_HK
dc.identifier.scopusauthoridMak, HKF=7004699149en_HK
dc.identifier.scopusauthoridWong, WS=8737892100en_HK
dc.identifier.scopusauthoridKhong, PL=7006693233en_HK
dc.identifier.scopusauthoridLau, CS=14035682100en_HK

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