File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Pattern of arterial calcification in patients with systemic lupus erythematosus

TitlePattern of arterial calcification in patients with systemic lupus erythematosus
Authors
KeywordsSystemic lupus erythematosus
Vascular calcification
Issue Date2009
PublisherJournal of Rheumatology Publishing Co Ltd. The Journal's web site is located at http://www.jrheum.com
Citation
Journal Of Rheumatology, 2009, v. 36 n. 10, p. 2212-2217 How to Cite?
AbstractObjective. To evaluate the prevalence and pattern of arterial calcification in patients with asymptomatic systemic lupus erythematosus (SLE) compared with control subjects. SLE patients are prone to adverse cardiovascular events; however, the underlying atherosclerotic process is unknown. Multidetector computed tomography (MDCT) measured arterial calcium score (CS) reflecting underlying atherosclerosis and is closely associated with cardiovascular events. Methods. Fifty age and sex matched SLE patients and controls were enrolled. All subjects underwent 64 slice MDCT scan to evaluate CS in coronary, carotid arteries and the aorta. Results. As compared with controls, SLE patients had higher mean CS and prevalence of CS > 0 across all vascular beds. After adjustment for age and sex, SLE patient odds of having CS > 0 in any vascular bed was 33.6 (95% CI: 9.5-165.2) were higher versus patients in the control group, mainly due to more prevalent coronary calcification (OR 30.0, 95% CI: 6.7-203.8). In SLE patients, the most frequent vessel with CS > 0 was coronary (42%) followed by carotid artery (24%). Further, arterial calcification occurred early involving 40% of SLE patients at age < 40 years , with increasing prevalence as age advanced. Conclusion. Our study confirms that patients with SLE have significantly higher prevalence and extent of systemic arterial calcification compared with age and sex matched controls. The Journal of Rheumatology Copyright © 2009. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/72340
ISSN
2015 Impact Factor: 3.236
2015 SCImago Journal Rankings: 1.225
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYiu, KHen_HK
dc.contributor.authorWang, Sen_HK
dc.contributor.authorMok, MOYen_HK
dc.contributor.authorOoi, GCen_HK
dc.contributor.authorKhong, PLen_HK
dc.contributor.authorMak, KAFHen_HK
dc.contributor.authorLam, KFen_HK
dc.contributor.authorLau, CSen_HK
dc.contributor.authorTse, HFen_HK
dc.date.accessioned2010-09-06T06:40:42Z-
dc.date.available2010-09-06T06:40:42Z-
dc.date.issued2009en_HK
dc.identifier.citationJournal Of Rheumatology, 2009, v. 36 n. 10, p. 2212-2217en_HK
dc.identifier.issn0315-162Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/72340-
dc.description.abstractObjective. To evaluate the prevalence and pattern of arterial calcification in patients with asymptomatic systemic lupus erythematosus (SLE) compared with control subjects. SLE patients are prone to adverse cardiovascular events; however, the underlying atherosclerotic process is unknown. Multidetector computed tomography (MDCT) measured arterial calcium score (CS) reflecting underlying atherosclerosis and is closely associated with cardiovascular events. Methods. Fifty age and sex matched SLE patients and controls were enrolled. All subjects underwent 64 slice MDCT scan to evaluate CS in coronary, carotid arteries and the aorta. Results. As compared with controls, SLE patients had higher mean CS and prevalence of CS > 0 across all vascular beds. After adjustment for age and sex, SLE patient odds of having CS > 0 in any vascular bed was 33.6 (95% CI: 9.5-165.2) were higher versus patients in the control group, mainly due to more prevalent coronary calcification (OR 30.0, 95% CI: 6.7-203.8). In SLE patients, the most frequent vessel with CS > 0 was coronary (42%) followed by carotid artery (24%). Further, arterial calcification occurred early involving 40% of SLE patients at age < 40 years , with increasing prevalence as age advanced. Conclusion. Our study confirms that patients with SLE have significantly higher prevalence and extent of systemic arterial calcification compared with age and sex matched controls. The Journal of Rheumatology Copyright © 2009. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherJournal of Rheumatology Publishing Co Ltd. The Journal's web site is located at http://www.jrheum.comen_HK
dc.relation.ispartofJournal of Rheumatologyen_HK
dc.subjectSystemic lupus erythematosusen_HK
dc.subjectVascular calcificationen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAorta, Thoracic - pathology - radiographyen_HK
dc.subject.meshAtherosclerosis - epidemiology - physiopathology - radiographyen_HK
dc.subject.meshCalcinosis - epidemiology - physiopathology - radiographyen_HK
dc.subject.meshCardiovascular Diseases - epidemiology - physiopathology - radiographyen_HK
dc.subject.meshCardiovascular System - pathology - physiopathology - radiographyen_HK
dc.subject.meshCarotid Arteries - pathology - radiographyen_HK
dc.subject.meshCase-Control Studiesen_HK
dc.subject.meshCoronary Vessels - pathologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHong Kongen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLupus Erythematosus, Systemic - complications - physiopathologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPrevalenceen_HK
dc.subject.meshRisk Factorsen_HK
dc.subject.meshTomography, Spiral Computeden_HK
dc.titlePattern of arterial calcification in patients with systemic lupus erythematosusen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0315-162X&volume=&spage=&epage=&date=2009&atitle=Pattern+of+arterial+calcification+in+patients+with+systemic+lupus+erythematosusen_HK
dc.identifier.emailYiu, KH: khkyiu@hku.hken_HK
dc.identifier.emailKhong, PL: plkhong@hkucc.hku.hken_HK
dc.identifier.emailMak, KAFH: makkf@hkucc.hku.hken_HK
dc.identifier.emailLam, KF: hrntlkf@hkucc.hku.hken_HK
dc.identifier.emailLau, CS: cslau@hku.hken_HK
dc.identifier.emailTse, HF: hftse@hkucc.hku.hken_HK
dc.identifier.authorityYiu, KH=rp01490en_HK
dc.identifier.authorityKhong, PL=rp00467en_HK
dc.identifier.authorityMak, KAFH=rp00533en_HK
dc.identifier.authorityLam, KF=rp00718en_HK
dc.identifier.authorityLau, CS=rp01348en_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.3899/jrheum.090312en_HK
dc.identifier.pmid19755615-
dc.identifier.scopuseid_2-s2.0-70450186219en_HK
dc.identifier.hkuros160319en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70450186219&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume36en_HK
dc.identifier.issue10en_HK
dc.identifier.spage2212en_HK
dc.identifier.epage2217en_HK
dc.identifier.isiWOS:000270691200013-
dc.publisher.placeCanadaen_HK
dc.identifier.scopusauthoridYiu, KH=35172267800en_HK
dc.identifier.scopusauthoridWang, S=24598284300en_HK
dc.identifier.scopusauthoridMok, MOY=25951401500en_HK
dc.identifier.scopusauthoridOoi, GC=7006176119en_HK
dc.identifier.scopusauthoridKhong, PL=7006693233en_HK
dc.identifier.scopusauthoridMak, KAFH=7004699149en_HK
dc.identifier.scopusauthoridLam, KF=8948421200en_HK
dc.identifier.scopusauthoridLau, CS=14035682100en_HK
dc.identifier.scopusauthoridTse, HF=7006070805en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats