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Article: Cyclin D1 expression in oral squamous cell carcinomas: Clinicopathological relevance and correlation with p53 expression

TitleCyclin D1 expression in oral squamous cell carcinomas: Clinicopathological relevance and correlation with p53 expression
Authors
KeywordsCyclin D1
Oral
p53
Squamous cell carcinoma
Issue Date2000
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JOPM
Citation
Journal Of Oral Pathology And Medicine, 2000, v. 29 n. 4, p. 167-172 How to Cite?
AbstractThe aim of the present study is to study the relationship between cyclin D1 and the clinicopathological features of oral squamous cell carcinomas. The cyclin D1 and p53 expression in oral squamous cell carcinomas from 56 patients (45 men, 11 women) was studied by immunohistochemistry using monoclonal antibodies. The correlation between cyclin D1 and the clinicopathological features of the oral cancers was evaluated. Cyclin D1 expression was found in 63% of oral squamous cell carcinomas; it was often weak but was more frequently positive in high-grade lesions (P=0.019). The expression was positively correlated with p53 expression (P=0.06). Radiation therapy did not alter the expression of either cyclin D1 or p53 proteins. Expression of these proteins was not related to the age, gender or survival of the patients, or to stages of the tumors. The cyclin D1 expression was more frequently seen in patients with squamous cell carcinomas of oropharynx, palate, floor of mouth and gingiva. To conclude, cyclin D1 was frequently expressed in oral squamous cell carcinomas. This expression was related to the grade of the tumors and was not similar in various regions in the oral cavity, which may indicate the different tumor biology of cancers from these regions.
Persistent Identifierhttp://hdl.handle.net/10722/72000
ISSN
2015 Impact Factor: 1.859
2015 SCImago Journal Rankings: 0.731
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLam, KYen_HK
dc.contributor.authorNg, IOLen_HK
dc.contributor.authorYuen, APWen_HK
dc.contributor.authorKwong, DLWen_HK
dc.contributor.authorWei, Wen_HK
dc.date.accessioned2010-09-06T06:37:21Z-
dc.date.available2010-09-06T06:37:21Z-
dc.date.issued2000en_HK
dc.identifier.citationJournal Of Oral Pathology And Medicine, 2000, v. 29 n. 4, p. 167-172en_HK
dc.identifier.issn0904-2512en_HK
dc.identifier.urihttp://hdl.handle.net/10722/72000-
dc.description.abstractThe aim of the present study is to study the relationship between cyclin D1 and the clinicopathological features of oral squamous cell carcinomas. The cyclin D1 and p53 expression in oral squamous cell carcinomas from 56 patients (45 men, 11 women) was studied by immunohistochemistry using monoclonal antibodies. The correlation between cyclin D1 and the clinicopathological features of the oral cancers was evaluated. Cyclin D1 expression was found in 63% of oral squamous cell carcinomas; it was often weak but was more frequently positive in high-grade lesions (P=0.019). The expression was positively correlated with p53 expression (P=0.06). Radiation therapy did not alter the expression of either cyclin D1 or p53 proteins. Expression of these proteins was not related to the age, gender or survival of the patients, or to stages of the tumors. The cyclin D1 expression was more frequently seen in patients with squamous cell carcinomas of oropharynx, palate, floor of mouth and gingiva. To conclude, cyclin D1 was frequently expressed in oral squamous cell carcinomas. This expression was related to the grade of the tumors and was not similar in various regions in the oral cavity, which may indicate the different tumor biology of cancers from these regions.en_HK
dc.languageengen_HK
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JOPMen_HK
dc.relation.ispartofJournal of Oral Pathology and Medicineen_HK
dc.subjectCyclin D1en_HK
dc.subjectOralen_HK
dc.subjectp53en_HK
dc.subjectSquamous cell carcinomaen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAge Factorsen_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshAntibodies, Monoclonal - diagnostic useen_HK
dc.subject.meshCarcinoma, Squamous Cell - genetics - pathology - radiotherapyen_HK
dc.subject.meshChi-Square Distributionen_HK
dc.subject.meshCyclin D1 - geneticsen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGene Expression Regulation, Neoplasticen_HK
dc.subject.meshGingival Neoplasms - genetics - pathologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshMouth Floor - pathologyen_HK
dc.subject.meshMouth Neoplasms - genetics - pathology - radiotherapyen_HK
dc.subject.meshNeoplasm Stagingen_HK
dc.subject.meshOropharyngeal Neoplasms - genetics - pathologyen_HK
dc.subject.meshPalatal Neoplasms - genetics - pathologyen_HK
dc.subject.meshSex Factorsen_HK
dc.subject.meshSurvival Rateen_HK
dc.subject.meshTumor Suppressor Protein p53 - geneticsen_HK
dc.titleCyclin D1 expression in oral squamous cell carcinomas: Clinicopathological relevance and correlation with p53 expressionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0278-2391&volume=29&spage=167&epage=172&date=2000&atitle=Cyclin+D1+expression+in+oral+squamous+cell+carcinomas:+clinicopathological+relevance+and+correlation+with+p53+expressionen_HK
dc.identifier.emailNg, IOL: iolng@hkucc.hku.hken_HK
dc.identifier.emailKwong, DLW: dlwkwong@hku.hken_HK
dc.identifier.emailWei, W: hrmswwi@hku.hken_HK
dc.identifier.authorityNg, IOL=rp00335en_HK
dc.identifier.authorityKwong, DLW=rp00414en_HK
dc.identifier.authorityWei, W=rp00323en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1034/j.1600-0714.2000.290404.xen_HK
dc.identifier.pmid10766394-
dc.identifier.scopuseid_2-s2.0-0034024114en_HK
dc.identifier.hkuros50595en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034024114&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume29en_HK
dc.identifier.issue4en_HK
dc.identifier.spage167en_HK
dc.identifier.epage172en_HK
dc.identifier.isiWOS:000086558400004-
dc.publisher.placeDenmarken_HK
dc.identifier.scopusauthoridLam, KY=7403657165en_HK
dc.identifier.scopusauthoridNg, IOL=7102753722en_HK
dc.identifier.scopusauthoridYuen, APW=7006290111en_HK
dc.identifier.scopusauthoridKwong, DLW=15744231600en_HK
dc.identifier.scopusauthoridWei, W=7403321552en_HK

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