File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Chromosomal Aberrations in Esophageal Squamous Cell Carcinoma among Chinese: Gain of 12p Predicts Poor Prognosis after Surgery

TitleChromosomal Aberrations in Esophageal Squamous Cell Carcinoma among Chinese: Gain of 12p Predicts Poor Prognosis after Surgery
Authors
KeywordsComparative genomic hybridization
Esophageal carcinoma
Prognosis
Issue Date2004
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpath
Citation
Human Pathology, 2004, v. 35 n. 3, p. 309-316 How to Cite?
AbstractSixty primary esophageal squamous cell carcinomas (ESCCs) were evaluated for cytogenetic changes by comparative genomic hybridization (CGH). Recurrent chromosomal aberrations were correlated with stage and clinical outcome after esophagectomy to identify cytogenetic changes that are of prognostic significance. Chromosomal aberrations were found in 52 (86.7%) cases. The most frequently detected chromosomal gains involved 3q (67.3%), 8q (57.7%), 5p (51.9%), 7q (28.8%), 15q (28.8%), 20p (21.2%), 20q (28.8%), 1q (26.9%), 7p (26.9%), 2p (23.1%), and 12p (23.1%). Chromosome 12p was most frequently involved in high-level amplification. Six of the 12 cases with gain in 12p showed high-level amplification and the minimum overlapping region localized to 12pter-p13. The most frequently detected chromosomal loss involved 3p (46.2%), 4q (26.9%), 4p (23.1%), 3q (19.2%), 9p (17.3%), 19p (17.3%), and whole 13 (15.4%). No significant correlation was found between the recurrent chromosomal aberrations and pathological stage of ESCC. Univariate analysis demonstrated that late pathological stage (III and IV), gain in 12p, and loss in 3p are associated with poor relapse-free survival. Multivariate analysis confirmed gain in 12p as independent prognosticator for relapse-free survival after esophagectomy besides pathological stage. We conclude that chromosomal aberrations are common in ESCC. Gain in 12p is indicative of poor prognosis after esophagectomy, and combined modality therapy would be indicated in these patients. © 2004 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/71968
ISSN
2015 Impact Factor: 2.791
2015 SCImago Journal Rankings: 1.363
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKwong, Den_HK
dc.contributor.authorLam, Aen_HK
dc.contributor.authorGuan, Xen_HK
dc.contributor.authorLaw, Sen_HK
dc.contributor.authorTai, Aen_HK
dc.contributor.authorWong, Jen_HK
dc.contributor.authorSham, Jen_HK
dc.date.accessioned2010-09-06T06:37:00Z-
dc.date.available2010-09-06T06:37:00Z-
dc.date.issued2004en_HK
dc.identifier.citationHuman Pathology, 2004, v. 35 n. 3, p. 309-316en_HK
dc.identifier.issn0046-8177en_HK
dc.identifier.urihttp://hdl.handle.net/10722/71968-
dc.description.abstractSixty primary esophageal squamous cell carcinomas (ESCCs) were evaluated for cytogenetic changes by comparative genomic hybridization (CGH). Recurrent chromosomal aberrations were correlated with stage and clinical outcome after esophagectomy to identify cytogenetic changes that are of prognostic significance. Chromosomal aberrations were found in 52 (86.7%) cases. The most frequently detected chromosomal gains involved 3q (67.3%), 8q (57.7%), 5p (51.9%), 7q (28.8%), 15q (28.8%), 20p (21.2%), 20q (28.8%), 1q (26.9%), 7p (26.9%), 2p (23.1%), and 12p (23.1%). Chromosome 12p was most frequently involved in high-level amplification. Six of the 12 cases with gain in 12p showed high-level amplification and the minimum overlapping region localized to 12pter-p13. The most frequently detected chromosomal loss involved 3p (46.2%), 4q (26.9%), 4p (23.1%), 3q (19.2%), 9p (17.3%), 19p (17.3%), and whole 13 (15.4%). No significant correlation was found between the recurrent chromosomal aberrations and pathological stage of ESCC. Univariate analysis demonstrated that late pathological stage (III and IV), gain in 12p, and loss in 3p are associated with poor relapse-free survival. Multivariate analysis confirmed gain in 12p as independent prognosticator for relapse-free survival after esophagectomy besides pathological stage. We conclude that chromosomal aberrations are common in ESCC. Gain in 12p is indicative of poor prognosis after esophagectomy, and combined modality therapy would be indicated in these patients. © 2004 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpathen_HK
dc.relation.ispartofHuman Pathologyen_HK
dc.subjectComparative genomic hybridizationen_HK
dc.subjectEsophageal carcinomaen_HK
dc.subjectPrognosisen_HK
dc.subject.meshAsian Continental Ancestry Groupen_HK
dc.subject.meshCarcinoma, Squamous Cell - genetics - pathology - surgeryen_HK
dc.subject.meshChromosome Aberrationsen_HK
dc.subject.meshChromosomes, Human, Pair 12 - geneticsen_HK
dc.subject.meshDNA, Neoplasm - analysisen_HK
dc.subject.meshDisease-Free Survivalen_HK
dc.subject.meshEsophageal Neoplasms - genetics - pathology - surgeryen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImage Processing, Computer-Assisteden_HK
dc.subject.meshIn Situ Hybridization, Fluorescenceen_HK
dc.subject.meshMaleen_HK
dc.subject.meshNeoplasm Recurrence, Localen_HK
dc.subject.meshNeoplasm Stagingen_HK
dc.subject.meshSpectral Karyotypingen_HK
dc.subject.meshTreatment Outcomeen_HK
dc.titleChromosomal Aberrations in Esophageal Squamous Cell Carcinoma among Chinese: Gain of 12p Predicts Poor Prognosis after Surgeryen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0046-8177&volume=35&issue=3&spage=309&epage=316&date=2004&atitle=Chromosomal+aberrations+in+esophageal+squamous+cell+carcinoma+among+Chinese:+gain+of+12p+predicts+poor+prognosis+after+surgeryen_HK
dc.identifier.emailKwong, D: dlwkwong@hku.hken_HK
dc.identifier.emailLaw, S: slaw@hku.hken_HK
dc.identifier.emailWong, J: jwong@hkucc.hku.hken_HK
dc.identifier.authorityKwong, D=rp00414en_HK
dc.identifier.authorityLaw, S=rp00437en_HK
dc.identifier.authorityWong, J=rp00322en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.humpath.2003.10.020en_HK
dc.identifier.pmid15017586-
dc.identifier.scopuseid_2-s2.0-1542405776en_HK
dc.identifier.hkuros115340en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1542405776&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume35en_HK
dc.identifier.issue3en_HK
dc.identifier.spage309en_HK
dc.identifier.epage316en_HK
dc.identifier.isiWOS:000220181200006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridKwong, D=15744231600en_HK
dc.identifier.scopusauthoridLam, A=7403657165en_HK
dc.identifier.scopusauthoridGuan, X=7201462349en_HK
dc.identifier.scopusauthoridLaw, S=7202241293en_HK
dc.identifier.scopusauthoridTai, A=8234187900en_HK
dc.identifier.scopusauthoridWong, J=8049324500en_HK
dc.identifier.scopusauthoridSham, J=7101655565en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats