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Article: Nasopharyngeal carcinoma: Relationship between 18F-FDG PET-CT maximum standardized uptake value, metabolic tumour volume and total lesion glycolysis and TNM classification

TitleNasopharyngeal carcinoma: Relationship between 18F-FDG PET-CT maximum standardized uptake value, metabolic tumour volume and total lesion glycolysis and TNM classification
Authors
KeywordsAmerican Joint Committee on Cancer stages
Nasopharyngeal carcinoma
Positron emission tomography-computed tomography
Standardized uptake value
Total lesion glycolysis
Issue Date2010
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.nuclearmedicinecomm.com
Citation
Nuclear Medicine Communications, 2010, v. 31 n. 3, p. 206-210 How to Cite?
AbstractPurpose: We aimed to evaluate the relationships between primary tumour; maximum standardized uptake value (SUVmax), metabolic tumour volume (TV) and total lesion glycolysis (TLG) and tumour-node metastases (TNM) classification in nasopharyngeal carcinoma (NPC) patients. Methods: Fluorine-18 fluorodeoxyglucose positron emission tomography-computed tomography scans of 57 consecutive newly diagnosed NPC patients (age range, 15-80 years) were retrospectively reviewed. SUVmax, TV and TLG were recorded. Two-tailed Spearman's correlation was used to analyse the relationships between the metabolic parameters and the TNM staging system. Results: Positive correlations were observed between SUVmax (P<0.001, R=0.516), TV (P<0.001, R=0.504) and TLG (P<0.001, R=0.620) and T-stage, and both TV and SUVmax were independent variables that significantly affected T-stage (P<0.001, adjusted R2=0.370). No other significant correlations were found between the metabolic parameters and TNM classification system. Conclusion: The metabolic parameters derived from fluorine-18 fluorodeoxyglucose positron emission tomography-computed tomography were positively correlated with T-stage in primary NPC. Our findings may suggest a complementary role of these parameters to TNM staging in prognostication of NPC patients. © 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Persistent Identifierhttp://hdl.handle.net/10722/71959
ISSN
2015 Impact Factor: 1.453
2015 SCImago Journal Rankings: 0.690
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, WKSen_HK
dc.contributor.authorMak, HKFen_HK
dc.contributor.authorHuang, Ben_HK
dc.contributor.authorYeung, DWCen_HK
dc.contributor.authorKwong, DLWen_HK
dc.contributor.authorKhong, PLen_HK
dc.date.accessioned2010-09-06T06:36:55Z-
dc.date.available2010-09-06T06:36:55Z-
dc.date.issued2010en_HK
dc.identifier.citationNuclear Medicine Communications, 2010, v. 31 n. 3, p. 206-210en_HK
dc.identifier.issn0143-3636en_HK
dc.identifier.urihttp://hdl.handle.net/10722/71959-
dc.description.abstractPurpose: We aimed to evaluate the relationships between primary tumour; maximum standardized uptake value (SUVmax), metabolic tumour volume (TV) and total lesion glycolysis (TLG) and tumour-node metastases (TNM) classification in nasopharyngeal carcinoma (NPC) patients. Methods: Fluorine-18 fluorodeoxyglucose positron emission tomography-computed tomography scans of 57 consecutive newly diagnosed NPC patients (age range, 15-80 years) were retrospectively reviewed. SUVmax, TV and TLG were recorded. Two-tailed Spearman's correlation was used to analyse the relationships between the metabolic parameters and the TNM staging system. Results: Positive correlations were observed between SUVmax (P<0.001, R=0.516), TV (P<0.001, R=0.504) and TLG (P<0.001, R=0.620) and T-stage, and both TV and SUVmax were independent variables that significantly affected T-stage (P<0.001, adjusted R2=0.370). No other significant correlations were found between the metabolic parameters and TNM classification system. Conclusion: The metabolic parameters derived from fluorine-18 fluorodeoxyglucose positron emission tomography-computed tomography were positively correlated with T-stage in primary NPC. Our findings may suggest a complementary role of these parameters to TNM staging in prognostication of NPC patients. © 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.nuclearmedicinecomm.comen_HK
dc.relation.ispartofNuclear Medicine Communicationsen_HK
dc.subjectAmerican Joint Committee on Cancer stagesen_HK
dc.subjectNasopharyngeal carcinomaen_HK
dc.subjectPositron emission tomography-computed tomographyen_HK
dc.subjectStandardized uptake valueen_HK
dc.subjectTotal lesion glycolysisen_HK
dc.subject.meshCarcinoma - radiotherapy-
dc.subject.meshFluorodeoxyglucose F18 - pharmacology-
dc.subject.meshNasopharyngeal Neoplasms - metabolism - radiotherapy-
dc.subject.meshPositron-Emission Tomography - methods-
dc.subject.meshTomography, X-Ray Computed - methods-
dc.titleNasopharyngeal carcinoma: Relationship between 18F-FDG PET-CT maximum standardized uptake value, metabolic tumour volume and total lesion glycolysis and TNM classificationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0143-3636&volume=31&issue=3&spage=206&epage=210&date=2010&atitle=Nasopharyngeal+carcinoma:+relationship+between+18F-FDG+PET-CT+maximum+standardized+uptake+value,+metabolic+tumour+volume+and+total+lesion+glycolysis+and+TNM+classificationen_HK
dc.identifier.emailMak, HKF:makkf@hkucc.hku.hken_HK
dc.identifier.emailKwong, DLW:dlwkwong@hku.hken_HK
dc.identifier.emailKhong, PL:plkhong@hkucc.hku.hken_HK
dc.identifier.authorityMak, HKF=rp00533en_HK
dc.identifier.authorityKwong, DLW=rp00414en_HK
dc.identifier.authorityKhong, PL=rp00467en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/MNM.0b013e328333e3efen_HK
dc.identifier.pmid19966594-
dc.identifier.scopuseid_2-s2.0-76749122812en_HK
dc.identifier.hkuros169774en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-76749122812&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume31en_HK
dc.identifier.issue3en_HK
dc.identifier.spage206en_HK
dc.identifier.epage210en_HK
dc.identifier.isiWOS:000274726500005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChan, WKS=54407898800en_HK
dc.identifier.scopusauthoridMak, HKF=7004699149en_HK
dc.identifier.scopusauthoridHuang, B=36087446500en_HK
dc.identifier.scopusauthoridYeung, DWC=7103391359en_HK
dc.identifier.scopusauthoridKwong, DLW=15744231600en_HK
dc.identifier.scopusauthoridKhong, PL=7006693233en_HK

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