Article: Fascin over-expression is associated with aggressiveness of oral squamous cell carcinoma

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TitleFascin over-expression is associated with aggressiveness of oral squamous cell carcinoma
AuthorsLee, TK1
Poon, RTP1
Man, K1
Guan, XY1
Ma, S1
Liu, XB1
Myers, JN2
Yuen, APW1
KeywordsAggressiveness
E-cadherin
Fascin
OSCC
Issue Date2007
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
CitationCancer Letters, 2007, v. 254 n. 2, p. 308-315 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.canlet.2007.03.017
AbstractOral squamous cell carcinoma (OSCC) is associated with a high potential of tumor recurrence and metastasis, leading to poor prognosis. Cell motility is an important factor in the progression and metastasis of cancers. Recently, Fascin has been linked to tumor progression by induction of cell motility. However, the precise roles of Fascin in OSCC have not been elucidated clearly. The aim of this study was to analyze the roles of Fascin in OSCC progression using OSCC clinical samples. We demonstrated that Fascin over-expression was found in OSCC clinical samples and its expression was significantly associated with nodal metastasis (p = 0.027), tumor recurrence (p < 0.001) and poor patients' overall survival (p = 0.013). Consistently, Fascin proteins were detected in all OSCC cell lines with the expression level corresponding to the invasion ability. To specifically investigate the mechanism of Fascin in OSCC, we examined the E-cadherin expression in the same set of OSCC specimens. Fascin was negatively correlated with E-cadherin expression (p = 0.018, r = -0.513). In conclusion, our findings suggested that Fascin over-expression might enhance OSCC aggressiveness, possibly by interacting with E-cadherin expression. © 2007 Elsevier Ireland Ltd. All rights reserved.
ISSN0304-3835
2011 Impact Factor: 4.238
2011 SCImago Journal Rankings: 0.494
DOIhttp://dx.doi.org/10.1016/j.canlet.2007.03.017
ISI Accession Number IDWOS:000249141500013
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorLee, TK
dc.contributor.authorPoon, RTP
dc.contributor.authorMan, K
dc.contributor.authorGuan, XY
dc.contributor.authorMa, S
dc.contributor.authorLiu, XB
dc.contributor.authorMyers, JN
dc.contributor.authorYuen, APW
dc.date.accessioned2010-09-06T06:36:26Z
dc.date.available2010-09-06T06:36:26Z
dc.date.issued2007
dc.description.abstractOral squamous cell carcinoma (OSCC) is associated with a high potential of tumor recurrence and metastasis, leading to poor prognosis. Cell motility is an important factor in the progression and metastasis of cancers. Recently, Fascin has been linked to tumor progression by induction of cell motility. However, the precise roles of Fascin in OSCC have not been elucidated clearly. The aim of this study was to analyze the roles of Fascin in OSCC progression using OSCC clinical samples. We demonstrated that Fascin over-expression was found in OSCC clinical samples and its expression was significantly associated with nodal metastasis (p = 0.027), tumor recurrence (p < 0.001) and poor patients' overall survival (p = 0.013). Consistently, Fascin proteins were detected in all OSCC cell lines with the expression level corresponding to the invasion ability. To specifically investigate the mechanism of Fascin in OSCC, we examined the E-cadherin expression in the same set of OSCC specimens. Fascin was negatively correlated with E-cadherin expression (p = 0.018, r = -0.513). In conclusion, our findings suggested that Fascin over-expression might enhance OSCC aggressiveness, possibly by interacting with E-cadherin expression. © 2007 Elsevier Ireland Ltd. All rights reserved.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationCancer Letters, 2007, v. 254 n. 2, p. 308-315 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.canlet.2007.03.017
dc.identifier.doihttp://dx.doi.org/10.1016/j.canlet.2007.03.017
dc.identifier.epage315
dc.identifier.hkuros137541
dc.identifier.isiWOS:000249141500013
dc.identifier.issn0304-3835
2011 Impact Factor: 4.238
2011 SCImago Journal Rankings: 0.494
dc.identifier.issue2
dc.identifier.openurl
dc.identifier.pmid17499430
dc.identifier.scopuseid_2-s2.0-34547372358
dc.identifier.spage308
dc.identifier.urihttp://hdl.handle.net/10722/71914
dc.identifier.volume254
dc.languageeng
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
dc.publisher.placeIreland
dc.relation.ispartofCancer Letters
dc.relation.referencesReferences in Scopus
dc.rightsCancer Letters. Copyright © Elsevier Ireland Ltd.
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshCarcinoma, Squamous Cell - genetics - pathology
dc.subject.meshCarrier Proteins - genetics
dc.subject.meshFemale
dc.subject.meshGene Expression Regulation, Neoplastic
dc.subject.meshHumans
dc.subject.meshImmunohistochemistry
dc.subject.meshMale
dc.subject.meshMicrofilament Proteins - genetics
dc.subject.meshMiddle Aged
dc.subject.meshMouth Neoplasms - genetics - pathology
dc.subject.meshNeoplasm Invasiveness
dc.subject.meshReverse Transcriptase Polymerase Chain Reaction
dc.subject.meshSmoking
dc.subjectAggressiveness
dc.subjectE-cadherin
dc.subjectFascin
dc.subjectOSCC
dc.titleFascin over-expression is associated with aggressiveness of oral squamous cell carcinoma
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. University of Texas M. D. Anderson Cancer Center