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Article: Fascin over-expression is associated with aggressiveness of oral squamous cell carcinoma

TitleFascin over-expression is associated with aggressiveness of oral squamous cell carcinoma
Authors
KeywordsAggressiveness
E-cadherin
Fascin
OSCC
Issue Date2007
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
Citation
Cancer Letters, 2007, v. 254 n. 2, p. 308-315 How to Cite?
AbstractOral squamous cell carcinoma (OSCC) is associated with a high potential of tumor recurrence and metastasis, leading to poor prognosis. Cell motility is an important factor in the progression and metastasis of cancers. Recently, Fascin has been linked to tumor progression by induction of cell motility. However, the precise roles of Fascin in OSCC have not been elucidated clearly. The aim of this study was to analyze the roles of Fascin in OSCC progression using OSCC clinical samples. We demonstrated that Fascin over-expression was found in OSCC clinical samples and its expression was significantly associated with nodal metastasis (p = 0.027), tumor recurrence (p < 0.001) and poor patients' overall survival (p = 0.013). Consistently, Fascin proteins were detected in all OSCC cell lines with the expression level corresponding to the invasion ability. To specifically investigate the mechanism of Fascin in OSCC, we examined the E-cadherin expression in the same set of OSCC specimens. Fascin was negatively correlated with E-cadherin expression (p = 0.018, r = -0.513). In conclusion, our findings suggested that Fascin over-expression might enhance OSCC aggressiveness, possibly by interacting with E-cadherin expression. © 2007 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/71914
ISSN
2014 Impact Factor: 5.621
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLee, TKen_HK
dc.contributor.authorPoon, RTPen_HK
dc.contributor.authorMan, Ken_HK
dc.contributor.authorGuan, XYen_HK
dc.contributor.authorMa, Sen_HK
dc.contributor.authorLiu, XBen_HK
dc.contributor.authorMyers, JNen_HK
dc.contributor.authorYuen, APWen_HK
dc.date.accessioned2010-09-06T06:36:26Z-
dc.date.available2010-09-06T06:36:26Z-
dc.date.issued2007en_HK
dc.identifier.citationCancer Letters, 2007, v. 254 n. 2, p. 308-315en_HK
dc.identifier.issn0304-3835en_HK
dc.identifier.urihttp://hdl.handle.net/10722/71914-
dc.description.abstractOral squamous cell carcinoma (OSCC) is associated with a high potential of tumor recurrence and metastasis, leading to poor prognosis. Cell motility is an important factor in the progression and metastasis of cancers. Recently, Fascin has been linked to tumor progression by induction of cell motility. However, the precise roles of Fascin in OSCC have not been elucidated clearly. The aim of this study was to analyze the roles of Fascin in OSCC progression using OSCC clinical samples. We demonstrated that Fascin over-expression was found in OSCC clinical samples and its expression was significantly associated with nodal metastasis (p = 0.027), tumor recurrence (p < 0.001) and poor patients' overall survival (p = 0.013). Consistently, Fascin proteins were detected in all OSCC cell lines with the expression level corresponding to the invasion ability. To specifically investigate the mechanism of Fascin in OSCC, we examined the E-cadherin expression in the same set of OSCC specimens. Fascin was negatively correlated with E-cadherin expression (p = 0.018, r = -0.513). In conclusion, our findings suggested that Fascin over-expression might enhance OSCC aggressiveness, possibly by interacting with E-cadherin expression. © 2007 Elsevier Ireland Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canleten_HK
dc.relation.ispartofCancer Lettersen_HK
dc.rightsCancer Letters. Copyright © Elsevier Ireland Ltd.en_HK
dc.subjectAggressivenessen_HK
dc.subjectE-cadherinen_HK
dc.subjectFascinen_HK
dc.subjectOSCCen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshCarcinoma, Squamous Cell - genetics - pathologyen_HK
dc.subject.meshCarrier Proteins - geneticsen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGene Expression Regulation, Neoplasticen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMicrofilament Proteins - geneticsen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshMouth Neoplasms - genetics - pathologyen_HK
dc.subject.meshNeoplasm Invasivenessen_HK
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen_HK
dc.subject.meshSmokingen_HK
dc.titleFascin over-expression is associated with aggressiveness of oral squamous cell carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0304-3835&volume=254&issue=2&spage=308&epage=315&date=2007&atitle=Fascin+over-expression+is+associated+with+aggressiveness+of+oral+squamous+cell+carcinomaen_HK
dc.identifier.emailLee, TK: tkwlee@hkucc.hku.hken_HK
dc.identifier.emailPoon, RTP: poontp@hkucc.hku.hken_HK
dc.identifier.emailMan, K: kwanman@hkucc.hku.hken_HK
dc.identifier.emailGuan, XY: xyguan@hkucc.hku.hken_HK
dc.identifier.emailMa, S: sma@pathology.hku.hken_HK
dc.identifier.authorityLee, TK=rp00447en_HK
dc.identifier.authorityPoon, RTP=rp00446en_HK
dc.identifier.authorityMan, K=rp00417en_HK
dc.identifier.authorityGuan, XY=rp00454en_HK
dc.identifier.authorityMa, S=rp00506en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.canlet.2007.03.017en_HK
dc.identifier.pmid17499430en_HK
dc.identifier.scopuseid_2-s2.0-34547372358en_HK
dc.identifier.hkuros137541en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34547372358&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume254en_HK
dc.identifier.issue2en_HK
dc.identifier.spage308en_HK
dc.identifier.epage315en_HK
dc.identifier.isiWOS:000249141500013-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridLee, TK=7501439435en_HK
dc.identifier.scopusauthoridPoon, RTP=7103097223en_HK
dc.identifier.scopusauthoridMan, K=7101754072en_HK
dc.identifier.scopusauthoridGuan, XY=7201463221en_HK
dc.identifier.scopusauthoridMa, S=16444895800en_HK
dc.identifier.scopusauthoridLiu, XB=26642902000en_HK
dc.identifier.scopusauthoridMyers, JN=7402996499en_HK
dc.identifier.scopusauthoridYuen, APW=7006290111en_HK

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