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Article: Fascin over-expression is associated with aggressiveness of oral squamous cell carcinoma
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TitleFascin over-expression is associated with aggressiveness of oral squamous cell carcinoma
 
AuthorsLee, TK1
Poon, RTP1
Man, K1
Guan, XY1
Ma, S1
Liu, XB1
Myers, JN2
Yuen, APW1
 
KeywordsAggressiveness
E-cadherin
Fascin
OSCC
 
Issue Date2007
 
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
 
CitationCancer Letters, 2007, v. 254 n. 2, p. 308-315 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.canlet.2007.03.017
 
AbstractOral squamous cell carcinoma (OSCC) is associated with a high potential of tumor recurrence and metastasis, leading to poor prognosis. Cell motility is an important factor in the progression and metastasis of cancers. Recently, Fascin has been linked to tumor progression by induction of cell motility. However, the precise roles of Fascin in OSCC have not been elucidated clearly. The aim of this study was to analyze the roles of Fascin in OSCC progression using OSCC clinical samples. We demonstrated that Fascin over-expression was found in OSCC clinical samples and its expression was significantly associated with nodal metastasis (p = 0.027), tumor recurrence (p < 0.001) and poor patients' overall survival (p = 0.013). Consistently, Fascin proteins were detected in all OSCC cell lines with the expression level corresponding to the invasion ability. To specifically investigate the mechanism of Fascin in OSCC, we examined the E-cadherin expression in the same set of OSCC specimens. Fascin was negatively correlated with E-cadherin expression (p = 0.018, r = -0.513). In conclusion, our findings suggested that Fascin over-expression might enhance OSCC aggressiveness, possibly by interacting with E-cadherin expression. © 2007 Elsevier Ireland Ltd. All rights reserved.
 
ISSN0304-3835
2012 Impact Factor: 4.258
2012 SCImago Journal Rankings: 1.502
 
DOIhttp://dx.doi.org/10.1016/j.canlet.2007.03.017
 
ISI Accession Number IDWOS:000249141500013
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLee, TK
 
dc.contributor.authorPoon, RTP
 
dc.contributor.authorMan, K
 
dc.contributor.authorGuan, XY
 
dc.contributor.authorMa, S
 
dc.contributor.authorLiu, XB
 
dc.contributor.authorMyers, JN
 
dc.contributor.authorYuen, APW
 
dc.date.accessioned2010-09-06T06:36:26Z
 
dc.date.available2010-09-06T06:36:26Z
 
dc.date.issued2007
 
dc.description.abstractOral squamous cell carcinoma (OSCC) is associated with a high potential of tumor recurrence and metastasis, leading to poor prognosis. Cell motility is an important factor in the progression and metastasis of cancers. Recently, Fascin has been linked to tumor progression by induction of cell motility. However, the precise roles of Fascin in OSCC have not been elucidated clearly. The aim of this study was to analyze the roles of Fascin in OSCC progression using OSCC clinical samples. We demonstrated that Fascin over-expression was found in OSCC clinical samples and its expression was significantly associated with nodal metastasis (p = 0.027), tumor recurrence (p < 0.001) and poor patients' overall survival (p = 0.013). Consistently, Fascin proteins were detected in all OSCC cell lines with the expression level corresponding to the invasion ability. To specifically investigate the mechanism of Fascin in OSCC, we examined the E-cadherin expression in the same set of OSCC specimens. Fascin was negatively correlated with E-cadherin expression (p = 0.018, r = -0.513). In conclusion, our findings suggested that Fascin over-expression might enhance OSCC aggressiveness, possibly by interacting with E-cadherin expression. © 2007 Elsevier Ireland Ltd. All rights reserved.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationCancer Letters, 2007, v. 254 n. 2, p. 308-315 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.canlet.2007.03.017
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.canlet.2007.03.017
 
dc.identifier.epage315
 
dc.identifier.hkuros137541
 
dc.identifier.isiWOS:000249141500013
 
dc.identifier.issn0304-3835
2012 Impact Factor: 4.258
2012 SCImago Journal Rankings: 1.502
 
dc.identifier.issue2
 
dc.identifier.openurl
 
dc.identifier.pmid17499430
 
dc.identifier.scopuseid_2-s2.0-34547372358
 
dc.identifier.spage308
 
dc.identifier.urihttp://hdl.handle.net/10722/71914
 
dc.identifier.volume254
 
dc.languageeng
 
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
 
dc.publisher.placeIreland
 
dc.relation.ispartofCancer Letters
 
dc.relation.referencesReferences in Scopus
 
dc.rightsCancer Letters. Copyright © Elsevier Ireland Ltd.
 
dc.subject.meshAdult
 
dc.subject.meshAged
 
dc.subject.meshAged, 80 and over
 
dc.subject.meshCarcinoma, Squamous Cell - genetics - pathology
 
dc.subject.meshCarrier Proteins - genetics
 
dc.subject.meshFemale
 
dc.subject.meshGene Expression Regulation, Neoplastic
 
dc.subject.meshHumans
 
dc.subject.meshImmunohistochemistry
 
dc.subject.meshMale
 
dc.subject.meshMicrofilament Proteins - genetics
 
dc.subject.meshMiddle Aged
 
dc.subject.meshMouth Neoplasms - genetics - pathology
 
dc.subject.meshNeoplasm Invasiveness
 
dc.subject.meshReverse Transcriptase Polymerase Chain Reaction
 
dc.subject.meshSmoking
 
dc.subjectAggressiveness
 
dc.subjectE-cadherin
 
dc.subjectFascin
 
dc.subjectOSCC
 
dc.titleFascin over-expression is associated with aggressiveness of oral squamous cell carcinoma
 
dc.typeArticle
 
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<contributor.author>Ma, S</contributor.author>
<contributor.author>Liu, XB</contributor.author>
<contributor.author>Myers, JN</contributor.author>
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Author Affiliations
  1. The University of Hong Kong
  2. University of Texas M. D. Anderson Cancer Center