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Article: White matter anisotropy in post-treatment childhood cancer survivors: Preliminary evidence of association with neurocognitive function
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TitleWhite matter anisotropy in post-treatment childhood cancer survivors: Preliminary evidence of association with neurocognitive function
 
AuthorsKhong, PL1
Leung, LHT1
Fung, ASM1
Fong, DYT1
Qiu, D1
Kwong, DLW1
Ooi, GC1
McAlanon, G1
Cao, G1
Chan, GCF1
 
Issue Date2006
 
PublisherAmerican Society of Clinical Oncology. The Journal's web site is located at http://www.jco.org/
 
CitationJournal Of Clinical Oncology, 2006, v. 24 n. 6, p. 884-890 [How to Cite?]
DOI: http://dx.doi.org/10.1200/JCO.2005.02.4505
 
AbstractPurpose: We aim to determine if the loss of white matter fractional anisotropy (FA), measured by diffusion tensor magnetic resonance imaging (DTI), in post-treatment childhood medulloblastoma (MED) and acute lymphoblastic leukemia (ALL) survivors correlate with intelligence quotient (IQ) scores. Materials and Methods: MED and ALL survivors (n = 30; 20 male, 10 female; age range, 6.0 to 22.1 years; mean, 13.1 years) were recruited for DTI and IQ tests. In this cross-sectional study, age-matched normal control (n = 55; 32 male, 23 female; age range, 6.0 to 23 years; mean, 12.1 years) DTI was obtained to compute percentage difference in white matter FA (AFA%) for each patient compared with the age-matched control group. Multivariate regression analysis was performed to determine the relationships between AFA%, age at treatment, irradiation dose, time interval from treatment, and full-scale IQ (FSIQ), verbal IQ (VIQ), and performance IQ (PIQ). Receiver operating characteristics curves were used to determine the best AFA% cutoffs for predicting FSIQ, VIQ, and PIQ of less than 85. Results: AFA% had a significant effect on FSIQ (adjusted r 2 = 0.439; P < .001), VIQ (adjusted r 2 = 0.237; P = .028), and PIQ (adjusted r 2 = 0.491; P < .001) after adjusting for the effects of age at treatment, irradiation dose, and time interval from treatment. The best AFA% value to predict less than 85 scores in FSIQ, VIQ, and PIQ was -3.3% with specificities of 100% and sensitivities ranging from 77.8% to 87.5%. Conclusion: Our preliminary findings suggest that white matter FA may be a clinically useful biomarker for the assessment of treatment-related neurotoxicity in post-treatment childhood cancer survivors. © 2006 by American Society of Clinical Oncology.
 
ISSN0732-183X
2013 Impact Factor: 17.879
 
DOIhttp://dx.doi.org/10.1200/JCO.2005.02.4505
 
ISI Accession Number IDWOS:000235469700011
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorKhong, PL
 
dc.contributor.authorLeung, LHT
 
dc.contributor.authorFung, ASM
 
dc.contributor.authorFong, DYT
 
dc.contributor.authorQiu, D
 
dc.contributor.authorKwong, DLW
 
dc.contributor.authorOoi, GC
 
dc.contributor.authorMcAlanon, G
 
dc.contributor.authorCao, G
 
dc.contributor.authorChan, GCF
 
dc.date.accessioned2010-09-06T06:36:19Z
 
dc.date.available2010-09-06T06:36:19Z
 
dc.date.issued2006
 
dc.description.abstractPurpose: We aim to determine if the loss of white matter fractional anisotropy (FA), measured by diffusion tensor magnetic resonance imaging (DTI), in post-treatment childhood medulloblastoma (MED) and acute lymphoblastic leukemia (ALL) survivors correlate with intelligence quotient (IQ) scores. Materials and Methods: MED and ALL survivors (n = 30; 20 male, 10 female; age range, 6.0 to 22.1 years; mean, 13.1 years) were recruited for DTI and IQ tests. In this cross-sectional study, age-matched normal control (n = 55; 32 male, 23 female; age range, 6.0 to 23 years; mean, 12.1 years) DTI was obtained to compute percentage difference in white matter FA (AFA%) for each patient compared with the age-matched control group. Multivariate regression analysis was performed to determine the relationships between AFA%, age at treatment, irradiation dose, time interval from treatment, and full-scale IQ (FSIQ), verbal IQ (VIQ), and performance IQ (PIQ). Receiver operating characteristics curves were used to determine the best AFA% cutoffs for predicting FSIQ, VIQ, and PIQ of less than 85. Results: AFA% had a significant effect on FSIQ (adjusted r 2 = 0.439; P < .001), VIQ (adjusted r 2 = 0.237; P = .028), and PIQ (adjusted r 2 = 0.491; P < .001) after adjusting for the effects of age at treatment, irradiation dose, and time interval from treatment. The best AFA% value to predict less than 85 scores in FSIQ, VIQ, and PIQ was -3.3% with specificities of 100% and sensitivities ranging from 77.8% to 87.5%. Conclusion: Our preliminary findings suggest that white matter FA may be a clinically useful biomarker for the assessment of treatment-related neurotoxicity in post-treatment childhood cancer survivors. © 2006 by American Society of Clinical Oncology.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Clinical Oncology, 2006, v. 24 n. 6, p. 884-890 [How to Cite?]
DOI: http://dx.doi.org/10.1200/JCO.2005.02.4505
 
dc.identifier.doihttp://dx.doi.org/10.1200/JCO.2005.02.4505
 
dc.identifier.eissn1527-7755
 
dc.identifier.epage890
 
dc.identifier.hkuros114548
 
dc.identifier.isiWOS:000235469700011
 
dc.identifier.issn0732-183X
2013 Impact Factor: 17.879
 
dc.identifier.issue6
 
dc.identifier.openurl
 
dc.identifier.pmid16484697
 
dc.identifier.scopuseid_2-s2.0-33644907754
 
dc.identifier.spage884
 
dc.identifier.urihttp://hdl.handle.net/10722/71903
 
dc.identifier.volume24
 
dc.languageeng
 
dc.publisherAmerican Society of Clinical Oncology. The Journal's web site is located at http://www.jco.org/
 
dc.publisher.placeUnited States
 
dc.relation.ispartofJournal of Clinical Oncology
 
dc.relation.referencesReferences in Scopus
 
dc.titleWhite matter anisotropy in post-treatment childhood cancer survivors: Preliminary evidence of association with neurocognitive function
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong