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Article: Fast water-exchange Gd3+-(DO3A-like) complex functionalized with Aza-15-crown-5 showing prolonged residence lifetime in vivo

TitleFast water-exchange Gd3+-(DO3A-like) complex functionalized with Aza-15-crown-5 showing prolonged residence lifetime in vivo
Authors
Issue Date2006
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/bc
Citation
Bioconjugate Chemistry, 2006, v. 17 n. 3, p. 571-574 How to Cite?
AbstractA bis-hydrated Gd3+ complex based on tris acetic acid-1,4,7,10-tetraazacyclododecane (DO3A) that was functionalized with aza-15-crown-5 demonstrated a nearly optimal water-exchanging rate (k ex = 3.1 × 107 s-1) and low acute cytotoxicity. Efficient magnetic resonance signal intensity enhancements and prolonged residence lifetime induced by this small molecular complex in vivo were demonstrated even with one-fifth of the standard dosage used in the clinic. © 2006 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/69654
ISSN
2014 Impact Factor: 4.513
2014 SCImago Journal Rankings: 1.604
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, Cen_HK
dc.contributor.authorLi, YXen_HK
dc.contributor.authorLaw, GLen_HK
dc.contributor.authorMan, Ken_HK
dc.contributor.authorWong, WTen_HK
dc.contributor.authorLei, Hen_HK
dc.date.accessioned2010-09-06T06:15:38Z-
dc.date.available2010-09-06T06:15:38Z-
dc.date.issued2006en_HK
dc.identifier.citationBioconjugate Chemistry, 2006, v. 17 n. 3, p. 571-574en_HK
dc.identifier.issn1043-1802en_HK
dc.identifier.urihttp://hdl.handle.net/10722/69654-
dc.description.abstractA bis-hydrated Gd3+ complex based on tris acetic acid-1,4,7,10-tetraazacyclododecane (DO3A) that was functionalized with aza-15-crown-5 demonstrated a nearly optimal water-exchanging rate (k ex = 3.1 × 107 s-1) and low acute cytotoxicity. Efficient magnetic resonance signal intensity enhancements and prolonged residence lifetime induced by this small molecular complex in vivo were demonstrated even with one-fifth of the standard dosage used in the clinic. © 2006 American Chemical Society.en_HK
dc.languageengen_HK
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/bcen_HK
dc.relation.ispartofBioconjugate Chemistryen_HK
dc.titleFast water-exchange Gd3+-(DO3A-like) complex functionalized with Aza-15-crown-5 showing prolonged residence lifetime in vivoen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1043-1802&volume=17&issue=3&spage=571&epage=574&date=2006&atitle=Fast+water-exchange+Gd3+-(DO3A-like)+complex+functionalized+with+aza-15-crown-5+showing+prolonged+residence+lifetime+in+vivoen_HK
dc.identifier.emailLaw, GL: h049044@hkusua.hku.hken_HK
dc.identifier.emailMan, K: kwanman@hku.hken_HK
dc.identifier.emailWong, WT: wtwong@hku.hken_HK
dc.identifier.authorityLaw, GL=rp00723en_HK
dc.identifier.authorityMan, K=rp00417en_HK
dc.identifier.authorityWong, WT=rp00811en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/bc060003men_HK
dc.identifier.pmid16704192en_HK
dc.identifier.scopuseid_2-s2.0-33646928338en_HK
dc.identifier.hkuros119297en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33646928338&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume17en_HK
dc.identifier.issue3en_HK
dc.identifier.spage571en_HK
dc.identifier.epage574en_HK
dc.identifier.isiWOS:000237576000002-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLi, C=8521804400en_HK
dc.identifier.scopusauthoridLi, YX=7502095948en_HK
dc.identifier.scopusauthoridLaw, GL=8640216600en_HK
dc.identifier.scopusauthoridMan, K=7101754072en_HK
dc.identifier.scopusauthoridWong, WT=7403973084en_HK
dc.identifier.scopusauthoridLei, H=7202480619en_HK

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