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Article: Fast water-exchange Gd3+-(DO3A-like) complex functionalized with Aza-15-crown-5 showing prolonged residence lifetime in vivo
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TitleFast water-exchange Gd3+-(DO3A-like) complex functionalized with Aza-15-crown-5 showing prolonged residence lifetime in vivo
 
AuthorsLi, C2
Li, YX3
Law, GL2
Man, K1
Wong, WT2
Lei, H3
 
Issue Date2006
 
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/bc
 
CitationBioconjugate Chemistry, 2006, v. 17 n. 3, p. 571-574 [How to Cite?]
DOI: http://dx.doi.org/10.1021/bc060003m
 
AbstractA bis-hydrated Gd3+ complex based on tris acetic acid-1,4,7,10-tetraazacyclododecane (DO3A) that was functionalized with aza-15-crown-5 demonstrated a nearly optimal water-exchanging rate (k ex = 3.1 × 107 s-1) and low acute cytotoxicity. Efficient magnetic resonance signal intensity enhancements and prolonged residence lifetime induced by this small molecular complex in vivo were demonstrated even with one-fifth of the standard dosage used in the clinic. © 2006 American Chemical Society.
 
ISSN1043-1802
2013 Impact Factor: 4.821
 
DOIhttp://dx.doi.org/10.1021/bc060003m
 
ISI Accession Number IDWOS:000237576000002
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLi, C
 
dc.contributor.authorLi, YX
 
dc.contributor.authorLaw, GL
 
dc.contributor.authorMan, K
 
dc.contributor.authorWong, WT
 
dc.contributor.authorLei, H
 
dc.date.accessioned2010-09-06T06:15:38Z
 
dc.date.available2010-09-06T06:15:38Z
 
dc.date.issued2006
 
dc.description.abstractA bis-hydrated Gd3+ complex based on tris acetic acid-1,4,7,10-tetraazacyclododecane (DO3A) that was functionalized with aza-15-crown-5 demonstrated a nearly optimal water-exchanging rate (k ex = 3.1 × 107 s-1) and low acute cytotoxicity. Efficient magnetic resonance signal intensity enhancements and prolonged residence lifetime induced by this small molecular complex in vivo were demonstrated even with one-fifth of the standard dosage used in the clinic. © 2006 American Chemical Society.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationBioconjugate Chemistry, 2006, v. 17 n. 3, p. 571-574 [How to Cite?]
DOI: http://dx.doi.org/10.1021/bc060003m
 
dc.identifier.doihttp://dx.doi.org/10.1021/bc060003m
 
dc.identifier.epage574
 
dc.identifier.hkuros119297
 
dc.identifier.isiWOS:000237576000002
 
dc.identifier.issn1043-1802
2013 Impact Factor: 4.821
 
dc.identifier.issue3
 
dc.identifier.openurl
 
dc.identifier.pmid16704192
 
dc.identifier.scopuseid_2-s2.0-33646928338
 
dc.identifier.spage571
 
dc.identifier.urihttp://hdl.handle.net/10722/69654
 
dc.identifier.volume17
 
dc.languageeng
 
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/bc
 
dc.publisher.placeUnited States
 
dc.relation.ispartofBioconjugate Chemistry
 
dc.relation.referencesReferences in Scopus
 
dc.titleFast water-exchange Gd3+-(DO3A-like) complex functionalized with Aza-15-crown-5 showing prolonged residence lifetime in vivo
 
dc.typeArticle
 
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<description.abstract>A bis-hydrated Gd3+ complex based on tris acetic acid-1,4,7,10-tetraazacyclododecane (DO3A) that was functionalized with aza-15-crown-5 demonstrated a nearly optimal water-exchanging rate (k ex = 3.1 &#215; 107 s-1) and low acute cytotoxicity. Efficient magnetic resonance signal intensity enhancements and prolonged residence lifetime induced by this small molecular complex in vivo were demonstrated even with one-fifth of the standard dosage used in the clinic. &#169; 2006 American Chemical Society.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong
  2. Institute of Molecular Technology for Drug Discovery and Synthesis, Hong Kong
  3. Wuhan Institute of Physics and Mathematics Chinese Academy of Sciences