Article: Fast water-exchange Gd3+-(DO3A-like) complex functionalized with Aza-15-crown-5 showing prolonged residence lifetime in vivo

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TitleFast water-exchange Gd3+-(DO3A-like) complex functionalized with Aza-15-crown-5 showing prolonged residence lifetime in vivo
AuthorsLi, C2
Li, YX3
Law, GL2
Man, K1
Wong, WT2
Lei, H3
Issue Date2006
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/bc
CitationBioconjugate Chemistry, 2006, v. 17 n. 3, p. 571-574 [How to Cite?]
DOI: http://dx.doi.org/10.1021/bc060003m
AbstractA bis-hydrated Gd3+ complex based on tris acetic acid-1,4,7,10-tetraazacyclododecane (DO3A) that was functionalized with aza-15-crown-5 demonstrated a nearly optimal water-exchanging rate (k ex = 3.1 × 107 s-1) and low acute cytotoxicity. Efficient magnetic resonance signal intensity enhancements and prolonged residence lifetime induced by this small molecular complex in vivo were demonstrated even with one-fifth of the standard dosage used in the clinic. © 2006 American Chemical Society.
ISSN1043-1802
2011 Impact Factor: 4.93
2011 SCImago Journal Rankings: 0.484
DOIhttp://dx.doi.org/10.1021/bc060003m
ISI Accession Number IDWOS:000237576000002
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorLi, C
dc.contributor.authorLi, YX
dc.contributor.authorLaw, GL
dc.contributor.authorMan, K
dc.contributor.authorWong, WT
dc.contributor.authorLei, H
dc.date.accessioned2010-09-06T06:15:38Z
dc.date.available2010-09-06T06:15:38Z
dc.date.issued2006
dc.description.abstractA bis-hydrated Gd3+ complex based on tris acetic acid-1,4,7,10-tetraazacyclododecane (DO3A) that was functionalized with aza-15-crown-5 demonstrated a nearly optimal water-exchanging rate (k ex = 3.1 × 107 s-1) and low acute cytotoxicity. Efficient magnetic resonance signal intensity enhancements and prolonged residence lifetime induced by this small molecular complex in vivo were demonstrated even with one-fifth of the standard dosage used in the clinic. © 2006 American Chemical Society.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationBioconjugate Chemistry, 2006, v. 17 n. 3, p. 571-574 [How to Cite?]
DOI: http://dx.doi.org/10.1021/bc060003m
dc.identifier.doihttp://dx.doi.org/10.1021/bc060003m
dc.identifier.epage574
dc.identifier.hkuros119297
dc.identifier.isiWOS:000237576000002
dc.identifier.issn1043-1802
2011 Impact Factor: 4.93
2011 SCImago Journal Rankings: 0.484
dc.identifier.issue3
dc.identifier.openurl
dc.identifier.pmid16704192
dc.identifier.scopuseid_2-s2.0-33646928338
dc.identifier.spage571
dc.identifier.urihttp://hdl.handle.net/10722/69654
dc.identifier.volume17
dc.languageeng
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/bc
dc.publisher.placeUnited States
dc.relation.ispartofBioconjugate Chemistry
dc.relation.referencesReferences in Scopus
dc.titleFast water-exchange Gd3+-(DO3A-like) complex functionalized with Aza-15-crown-5 showing prolonged residence lifetime in vivo
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Institute of Molecular Technology for Drug Discovery and Synthesis, Hong Kong
  3. Wuhan Institute of Physics and Mathematics Chinese Academy of Sciences