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Article: The developmental roles of the extracellular matrix: Beyond structure to regulation

TitleThe developmental roles of the extracellular matrix: Beyond structure to regulation
Authors
KeywordsDevelopment
Extracellular matrix
Morphogenesis
Mouse model
Organogenesis
Issue Date2010
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00441/index.htm
Citation
Cell And Tissue Research, 2010, v. 339 n. 1, p. 93-110 How to Cite?
AbstractCells in multicellular organisms are surrounded by a complex three-dimensional macromolecular extracellular matrix (ECM). This matrix, traditionally thought to serve a structural function providing support and strength to cells within tissues, is increasingly being recognized as having pleiotropic effects in development and growth. Elucidation of the role that the ECM plays in developmental processes has been significantly advanced by studying the phenotypic and developmental consequences of specific genetic alterations of ECM components in the mouse. These studies have revealed the enormous contribution of the ECM to the regulation of key processes in morphogenesis and organogenesis, such as cell adhesion, proliferation, specification, migration, survival, and differentiation. The ECM interacts with signaling molecules and morphogens thereby modulating their activities. This review considers these advances in our understanding of the function of ECM proteins during development, extending beyond their structural capacity, to embrace their new roles in intercellula signaling. © 2009 Springer-Verlag.
Persistent Identifierhttp://hdl.handle.net/10722/68267
ISSN
2015 Impact Factor: 2.948
2015 SCImago Journal Rankings: 1.539
ISI Accession Number ID
Funding AgencyGrant Number
University Grants Committee of Hong Kong Area of ExcellenceAoE/M-04/04
Funding Information:

The authors are supported by the University Grants Committee of Hong Kong Area of Excellence programme AoE/M-04/04.

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorTsang, KYen_HK
dc.contributor.authorCheung, MCHen_HK
dc.contributor.authorChan, Den_HK
dc.contributor.authorCheah, KSEen_HK
dc.date.accessioned2010-09-06T06:02:57Z-
dc.date.available2010-09-06T06:02:57Z-
dc.date.issued2010en_HK
dc.identifier.citationCell And Tissue Research, 2010, v. 339 n. 1, p. 93-110en_HK
dc.identifier.issn0302-766Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/68267-
dc.description.abstractCells in multicellular organisms are surrounded by a complex three-dimensional macromolecular extracellular matrix (ECM). This matrix, traditionally thought to serve a structural function providing support and strength to cells within tissues, is increasingly being recognized as having pleiotropic effects in development and growth. Elucidation of the role that the ECM plays in developmental processes has been significantly advanced by studying the phenotypic and developmental consequences of specific genetic alterations of ECM components in the mouse. These studies have revealed the enormous contribution of the ECM to the regulation of key processes in morphogenesis and organogenesis, such as cell adhesion, proliferation, specification, migration, survival, and differentiation. The ECM interacts with signaling molecules and morphogens thereby modulating their activities. This review considers these advances in our understanding of the function of ECM proteins during development, extending beyond their structural capacity, to embrace their new roles in intercellula signaling. © 2009 Springer-Verlag.en_HK
dc.languageengen_HK
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00441/index.htmen_HK
dc.relation.ispartofCell and Tissue Researchen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsThe original publication is available at www.springerlink.com-
dc.subjectDevelopmenten_HK
dc.subjectExtracellular matrixen_HK
dc.subjectMorphogenesisen_HK
dc.subjectMouse modelen_HK
dc.subjectOrganogenesisen_HK
dc.subject.meshCell Differentiation - physiology-
dc.subject.meshCell Movement - physiology-
dc.subject.meshCell Proliferation-
dc.subject.meshExtracellular Matrix - genetics - metabolism-
dc.subject.meshOrganogenesis - physiology-
dc.titleThe developmental roles of the extracellular matrix: Beyond structure to regulationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0302-766X&volume=339&issue=1&spage=93&epage=110&date=2010&atitle=The+developmental+roles+of+the+extracellular+matrix:+beyond+structure+to+regulationen_HK
dc.identifier.emailCheung, MCH:mcheung9@hkucc.hku.hken_HK
dc.identifier.emailChan, D:chand@hkucc.hku.hken_HK
dc.identifier.emailCheah, KSE:hrmbdkc@hku.hken_HK
dc.identifier.authorityCheung, MCH=rp00245en_HK
dc.identifier.authorityChan, D=rp00540en_HK
dc.identifier.authorityCheah, KSE=rp00342en_HK
dc.description.naturepostprint-
dc.identifier.doi10.1007/s00441-009-0893-8en_HK
dc.identifier.pmid19885678-
dc.identifier.scopuseid_2-s2.0-72449210973en_HK
dc.identifier.hkuros169429en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-72449210973&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume339en_HK
dc.identifier.issue1en_HK
dc.identifier.spage93en_HK
dc.identifier.epage110en_HK
dc.identifier.eissn1432-0878-
dc.identifier.isiWOS:000273953300009-
dc.publisher.placeGermanyen_HK
dc.relation.projectDevelopmental genomics and skeletal research-
dc.identifier.scopusauthoridTsang, KY=22635904200en_HK
dc.identifier.scopusauthoridCheung, MCH=7201897461en_HK
dc.identifier.scopusauthoridChan, D=7402216545en_HK
dc.identifier.scopusauthoridCheah, KSE=35387746200en_HK
dc.identifier.citeulike6075686-

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