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Article: SiRNA and shRNA screens advance key understanding of host factors required for HIV-1 replication

TitleSiRNA and shRNA screens advance key understanding of host factors required for HIV-1 replication
Authors
Issue Date2009
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.retrovirology.com/home/
Citation
Retrovirology, 2009, v. 6, p. 78 How to Cite?
AbstractA recent RNAi screen used a genome-wide shRNA library to search for cellular factors required for HIV-1 replication. This work complements three other siRNA-based screening studies and potentially opens the door to the discovery of factors that are important for HIV-1 replication in physiological host cells such as T lymphocytes. shRNA screens can be further improved, and they could promise to unravel new pathways and new facets of virus-cell interactions. © 2009 Kok et al; licensee BioMed Central Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/68211
ISSN
2015 Impact Factor: 3.989
2015 SCImago Journal Rankings: 2.506
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKok, KHen_HK
dc.contributor.authorLei, Ten_HK
dc.contributor.authorJin, DYen_HK
dc.date.accessioned2010-09-06T06:02:25Z-
dc.date.available2010-09-06T06:02:25Z-
dc.date.issued2009en_HK
dc.identifier.citationRetrovirology, 2009, v. 6, p. 78en_HK
dc.identifier.issn1742-4690en_HK
dc.identifier.urihttp://hdl.handle.net/10722/68211-
dc.description.abstractA recent RNAi screen used a genome-wide shRNA library to search for cellular factors required for HIV-1 replication. This work complements three other siRNA-based screening studies and potentially opens the door to the discovery of factors that are important for HIV-1 replication in physiological host cells such as T lymphocytes. shRNA screens can be further improved, and they could promise to unravel new pathways and new facets of virus-cell interactions. © 2009 Kok et al; licensee BioMed Central Ltd.en_HK
dc.languageengen_HK
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.retrovirology.com/home/en_HK
dc.relation.ispartofRetrovirologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsRetrovirology. Copyright © BioMed Central Ltd.en_HK
dc.subject.meshCell Line-
dc.subject.meshGene Knockdown Techniques-
dc.subject.meshHIV-1 - physiology-
dc.subject.meshHost-Pathogen Interactions-
dc.subject.meshVirus Replication-
dc.titleSiRNA and shRNA screens advance key understanding of host factors required for HIV-1 replicationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1742-4690&volume=6&spage=78&epage=&date=2009&atitle=siRNA+and+shRNA+screens+advance+key+understanding+of+host+factors+required+for+HIV-1+replicationen_HK
dc.identifier.emailKok, KH:khkok@hku.hken_HK
dc.identifier.emailJin, DY:dyjin@hkucc.hku.hken_HK
dc.identifier.authorityKok, KH=rp01455en_HK
dc.identifier.authorityJin, DY=rp00452en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/1742-4690-6-78en_HK
dc.identifier.pmid19712452-
dc.identifier.pmcidPMC2743632-
dc.identifier.scopuseid_2-s2.0-70349921798en_HK
dc.identifier.hkuros166469en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70349921798&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume6en_HK
dc.identifier.spage78en_HK
dc.identifier.epage78en_HK
dc.identifier.isiWOS:000270145700001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridKok, KH=7006862631en_HK
dc.identifier.scopusauthoridLei, T=35194438500en_HK
dc.identifier.scopusauthoridJin, DY=7201973614en_HK
dc.identifier.citeulike5660179-

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