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Article: Molecular pathogenesis of hepatitis C virus-associated hepatocellular carcinoma

TitleMolecular pathogenesis of hepatitis C virus-associated hepatocellular carcinoma
Authors
Issue Date2007
PublisherFrontiers in Bioscience.
Citation
Frontiers In Bioscience, 2007, v. 12 n. 1, p. 222-233 How to Cite?
AbstractChronic infection with hepatitis C virus (HCV) is causally associated with the development of hepatocellular carcinoma (HCC). HCV is not cytolytic and replicates entirely in the cytoplasm. Viral interaction with the host leads to subversion of immune response and other defense mechanisms. The recent development of robust cell culture systems for HCV infection provides new opportunities for the study of virus-cell interaction and viral pathogenesis. HCV infection causes active inflammation and fibrosis, which ultimately progresses to cirrhosis. The onset of cirrhosis usually precedes the multistage process of tumor development, in which common themes of viral carcinogenesis can be identified. While chronic inflammation and cirrhosis are thought to play an important role in tumor initiation, the underlying mechanisms are incompletely understood. Recent studies have revealed that infection with HCV induces genome instability, leading to further genetic and epigenetic alterations which contribute to the full development of HCC tumor. The expression of viral oncoproteins such as C and NS5A is critically involved both in the induction of genome instability and in dysregulating cellular control of growth and signal transduction. A better understanding of the molecular pathogenesis of HCV will reveal novel strategies for the prevention and treatment of related diseases including HCC.
Persistent Identifierhttp://hdl.handle.net/10722/68204
ISSN
2015 Impact Factor: 2.484
2015 SCImago Journal Rankings: 1.583
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorJin, DYen_HK
dc.date.accessioned2010-09-06T06:02:21Z-
dc.date.available2010-09-06T06:02:21Z-
dc.date.issued2007en_HK
dc.identifier.citationFrontiers In Bioscience, 2007, v. 12 n. 1, p. 222-233en_HK
dc.identifier.issn1093-9946en_HK
dc.identifier.urihttp://hdl.handle.net/10722/68204-
dc.description.abstractChronic infection with hepatitis C virus (HCV) is causally associated with the development of hepatocellular carcinoma (HCC). HCV is not cytolytic and replicates entirely in the cytoplasm. Viral interaction with the host leads to subversion of immune response and other defense mechanisms. The recent development of robust cell culture systems for HCV infection provides new opportunities for the study of virus-cell interaction and viral pathogenesis. HCV infection causes active inflammation and fibrosis, which ultimately progresses to cirrhosis. The onset of cirrhosis usually precedes the multistage process of tumor development, in which common themes of viral carcinogenesis can be identified. While chronic inflammation and cirrhosis are thought to play an important role in tumor initiation, the underlying mechanisms are incompletely understood. Recent studies have revealed that infection with HCV induces genome instability, leading to further genetic and epigenetic alterations which contribute to the full development of HCC tumor. The expression of viral oncoproteins such as C and NS5A is critically involved both in the induction of genome instability and in dysregulating cellular control of growth and signal transduction. A better understanding of the molecular pathogenesis of HCV will reveal novel strategies for the prevention and treatment of related diseases including HCC.en_HK
dc.languageengen_HK
dc.publisherFrontiers in Bioscience.en_HK
dc.relation.ispartofFrontiers in Bioscienceen_HK
dc.subject.meshCarcinoma, Hepatocellular - genetics - virologyen_HK
dc.subject.meshHepacivirus - genetics - pathogenicity - physiologyen_HK
dc.subject.meshHepatitis C, Chronic - virologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLiver Neoplasms - genetics - virologyen_HK
dc.titleMolecular pathogenesis of hepatitis C virus-associated hepatocellular carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1093-9946&volume=12&spage=222&epage=233&date=2007&atitle=Molecular+pathogenesis+of+hepatitis+C+virus-associated+hepatocellular+carcinomaen_HK
dc.identifier.emailJin, DY:dyjin@hkucc.hku.hken_HK
dc.identifier.authorityJin, DY=rp00452en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.2741/2060en_HK
dc.identifier.pmid17127295-
dc.identifier.scopuseid_2-s2.0-34249819367en_HK
dc.identifier.hkuros126754en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34249819367&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume12en_HK
dc.identifier.issue1en_HK
dc.identifier.spage222en_HK
dc.identifier.epage233en_HK
dc.identifier.isiWOS:000243745000017-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridJin, DY=7201973614en_HK

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